SEC16_SCHPO - dbPTM
SEC16_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEC16_SCHPO
UniProt AC O14029
Protein Name COPII coat assembly protein sec16
Gene Name sec16
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1995
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side.
Protein Description Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity)..
Protein Sequence MDIESDHEPKESSVDLEGRHDSIRKSFEADDIDVTDENTIFSTSRKEQSTIEPMDSFVENNIANSSSQQSVSEIDIQLPSSEPKEGVKEESNLIESNSLDNVQEINPQNTIGDKSAHTEEESSNDNLVKITAGTIISDIMDEPVVDEDDKLSEEDLSKEDLETTLKGDENYSSSQKEIYDNDETIPKPPSPEVEKIETSTSVENAYITNSQYNDTLDMEDQTSDLITTFEHENEDHEVHEVPSIHGMEGTFETVNLTSEAGNEKEFNNDSVVLNTTPKEMQISSLDAVDKLEDKPVSNDNIKANIESSTTVDRASSQLESENNESTFFVHNQNSSGQHQTLDFVASKPVTDTPELSKENTLVSSENLNDPKPNLPETEVDFGEPLEVEAPSFVVQNNSAVQPTTQKTSEDSTDLHTNEIPNVAQPPSSFEKENNKDTSKLENPDISSSPLSPTEDLFPNDPEEENLFSAALGLNSNTGSQPSETQSKPSIDPSESITVTDNQDSLLFSQLTNNALQAENATKVSENTINDEELIDDSEFTSLMSNFLESSTVQTNKYLPKSSASPPANAPIVSSDVHKNENAGTARRAPQSGAFVASKAKYSSPYDLPEEIVQVAQQKRSVSQNYNRQYSFQPRPATPSNPPRSLPPPSGQVNAPMSQTPNPISFAYQHGTPLATPTMRANSFNSYPASSAEPIRRPATTTVGHTPNLYSPKTNTYNSRHMAYEMTKSHINVISPGPSLQVNAPYTPTSGELGNKVSNPTKEFVSTSSYAPAANTRNAIIREPGILSPLSPRVQPVLSRRESIISMGSSASSYVPLEIAPRPMSSLEHTMNSAMSPGNLQRTANLYKPMTTPNAYNIKNSNQRETKYPYQPQAINYSEVTQPGSSSLPTSGEEANIIRSPGFTPLAAQKDATIYTPSHAQATLYGNMDNNDRDNEGIHDILQSDMEPVLPPHNSAYHANAPVSSHSEGLNNRLPISPLPPQLHKTGTPSHQHGFDTAETTAKQYAPSIPPNFNPNVSIDTMTEGVALPSATLDSDKSSLHKRSAELSRNNSPRPDFLPLPNQPLLHSNLHSPVSPVVDSNEDSRLKFLSTQRPAFSFGPCGTIVMAFSTPSGLYTTSGKGTKFIAGPIKIEKLGDVLTDEYRHLKEFKGPYLASNGKVDKHGKAEAIEWLSKYIDRLNQSLEYDDKNITLKDKLLLLQCLKMLLEVSDRKLIVEKLRPILLPSFEIPEPCNTATSVQELINPEINQDDSPIVASRYCTTSFLHRFYEYLLSGNKDEALTYALQQKQWPYAIIVAHSIDAKTFQGVVRTFCKSEVKESMLRSGVGVNLQLSLQLMSDAHASSMSEFSSSTSLLNLADQSQASNALVAWKELLYNIIANHYSDQKEALRVLGTLLLQENRVYAAHLVYILSLSPDVCSNKSNSLFELVGLSKHNLYPSHDDLFDVTQLTEVLELVFNVYSEKTPVFFTHLVPYRLYEAEVLAEAGEVSAARKYCELIGNYLNRVAKKSNNVDPGFVLRVRDLTQQILENSAGSEDISSSWLGRTVSRPRLDTVLSSLGSKFSKFVAGDPNFDVMRPATVGPGPFGKVASQKNLTVQTNTNNAAMESFYSDRPTSSGPSYQNRTPLTGQESMNMGVYSPYRRSTEIAENMSMDGNAYPYTPASQENPYTPRHSQEDNASVLSQQPLTFYSNVADNSYMPVSASQEPKMGMGTAFNMPTNEVHGVGAEMASPYQPLQPASAHLPNLQPTLAPINQNAYVPSNIAPAMGAMQSAPSAEAVAAPSESLNLNKDRSQQAKQAAAQNVADLVRQEEEKEKQKQKAKKNAESGKKGGAKGWFSKLLRRDESKDQPTVYKAKLGEKSHLHYDKELKRWVNDDGSDLSNQAAPPPPPPMALPKAGPPSAAPTSALPPAGPPAGATAISGNPGMPAPVPLTGKETAVPLSSMPNAPPSVASNAKLPPASNNRKVDPLEDILQAMPPPTTRKARGKTSKRYVDVMRNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MDIESDHEPKES
---CCCCCCCCCCCC		44.6024763107
12PhosphorylationSDHEPKESSVDLEGR
CCCCCCCCCCCCCCC		41.6125720772
13PhosphorylationDHEPKESSVDLEGRH
CCCCCCCCCCCCCCH		22.2728889911
26PhosphorylationRHDSIRKSFEADDID
CHHHHHHHEECCCCC		20.6224763107
91PhosphorylationKEGVKEESNLIESNS
CCCCCHHHHCCCCCC		37.7229996109
96PhosphorylationEESNLIESNSLDNVQ
HHHHCCCCCCCCCHH		25.4024763107
98PhosphorylationSNLIESNSLDNVQEI
HHCCCCCCCCCHHHC		46.5121712547
115PhosphorylationQNTIGDKSAHTEEES
CCCCCCCCCCCCCCC		29.9821712547
118PhosphorylationIGDKSAHTEEESSND
CCCCCCCCCCCCCCC		44.8229996109
122PhosphorylationSAHTEEESSNDNLVK
CCCCCCCCCCCCEEE		37.4124763107
123PhosphorylationAHTEEESSNDNLVKI
CCCCCCCCCCCEEEE		52.0321712547
152PhosphorylationVDEDDKLSEEDLSKE
CCCCCCCCHHHCCHH		44.6824763107
157PhosphorylationKLSEEDLSKEDLETT
CCCHHHCCHHHHHHH		46.4524763107
190PhosphorylationETIPKPPSPEVEKIE
CCCCCCCCCCCEEEE		42.0728889911
270PhosphorylationEKEFNNDSVVLNTTP
CCCCCCCCEEEECCC		19.0924763107
276PhosphorylationDSVVLNTTPKEMQIS
CCEEEECCCHHHCCC		31.1528889911
297PhosphorylationKLEDKPVSNDNIKAN
HHCCCCCCCCCCCHH		47.1724763107
363PhosphorylationSKENTLVSSENLNDP
CCCCEECCCCCCCCC		34.7427738172
427PhosphorylationPNVAQPPSSFEKENN
CCCCCCCCHHCCCCC		55.1027738172
561PhosphorylationTNKYLPKSSASPPAN
CCCCCCCCCCCCCCC		29.2421712547
562PhosphorylationNKYLPKSSASPPANA
CCCCCCCCCCCCCCC		38.6029996109
564PhosphorylationYLPKSSASPPANAPI
CCCCCCCCCCCCCCC		33.1128889911
622PhosphorylationAQQKRSVSQNYNRQY
HHHHHCCCCCCCCCC		17.6029996109
629PhosphorylationSQNYNRQYSFQPRPA
CCCCCCCCCCCCCCC		14.2829996109
630PhosphorylationQNYNRQYSFQPRPAT
CCCCCCCCCCCCCCC		14.7429996109
637PhosphorylationSFQPRPATPSNPPRS
CCCCCCCCCCCCCCC		29.9029996109
682PhosphorylationTPTMRANSFNSYPAS
CCCCCCCCCCCCCCC		25.4829996109
690PhosphorylationFNSYPASSAEPIRRP
CCCCCCCCCCCCCCC		38.4629996109
699PhosphorylationEPIRRPATTTVGHTP
CCCCCCCCCCCCCCC		26.1925720772
701PhosphorylationIRRPATTTVGHTPNL
CCCCCCCCCCCCCCC		21.8225720772
705PhosphorylationATTTVGHTPNLYSPK
CCCCCCCCCCCCCCC		14.1425720772
709PhosphorylationVGHTPNLYSPKTNTY
CCCCCCCCCCCCCCC		29.5728889911
710PhosphorylationGHTPNLYSPKTNTYN
CCCCCCCCCCCCCCC		24.0829996109
728PhosphorylationMAYEMTKSHINVISP
HHHHHHHHHEEEECC		22.0421712547
734PhosphorylationKSHINVISPGPSLQV
HHHEEEECCCCCCCC		21.3724763107
738PhosphorylationNVISPGPSLQVNAPY
EEECCCCCCCCCCCC		37.0321712547
745PhosphorylationSLQVNAPYTPTSGEL
CCCCCCCCCCCCCCC		23.9621712547
746PhosphorylationLQVNAPYTPTSGELG
CCCCCCCCCCCCCCC		21.0221712547
748PhosphorylationVNAPYTPTSGELGNK
CCCCCCCCCCCCCCC		41.3821712547
749PhosphorylationNAPYTPTSGELGNKV
CCCCCCCCCCCCCCC		31.3229996109
787PhosphorylationIREPGILSPLSPRVQ
CCCCCCCCCCCCCCH		23.1329996109
790PhosphorylationPGILSPLSPRVQPVL
CCCCCCCCCCCHHHH		17.6528889911
798PhosphorylationPRVQPVLSRRESIIS
CCCHHHHCCCHHHEE		29.5329996109
802PhosphorylationPVLSRRESIISMGSS
HHHCCCHHHEECCCC		24.3429996109
805PhosphorylationSRRESIISMGSSASS
CCCHHHEECCCCCHH		18.5429996109
808PhosphorylationESIISMGSSASSYVP
HHHEECCCCCHHCCC		17.6829996109
809PhosphorylationSIISMGSSASSYVPL
HHEECCCCCHHCCCC		26.8329996109
811PhosphorylationISMGSSASSYVPLEI
EECCCCCHHCCCCEE		24.9329996109
824PhosphorylationEIAPRPMSSLEHTMN
EECCCCCCCCHHHHH		34.1629996109
829PhosphorylationPMSSLEHTMNSAMSP
CCCCCHHHHHCCCCC		14.5229996109
832PhosphorylationSLEHTMNSAMSPGNL
CCHHHHHCCCCCCCH		17.9629996109
835PhosphorylationHTMNSAMSPGNLQRT
HHHHCCCCCCCHHHH		29.4029996109
884PhosphorylationSEVTQPGSSSLPTSG
CCCCCCCCCCCCCCC		24.3627738172
885PhosphorylationEVTQPGSSSLPTSGE
CCCCCCCCCCCCCCC		41.6429996109
886PhosphorylationVTQPGSSSLPTSGEE
CCCCCCCCCCCCCCC		39.8129996109
899PhosphorylationEEANIIRSPGFTPLA
CCCEEEECCCCCCCC		20.9728889911
903PhosphorylationIIRSPGFTPLAAQKD
EEECCCCCCCCCCCC		24.2529996109
976PhosphorylationLNNRLPISPLPPQLH
CCCCCCCCCCCCCCC		20.6029996109
985PhosphorylationLPPQLHKTGTPSHQH
CCCCCCCCCCCCHHC		35.2224763107
987PhosphorylationPQLHKTGTPSHQHGF
CCCCCCCCCCHHCCC		27.1825720772
989PhosphorylationLHKTGTPSHQHGFDT
CCCCCCCCHHCCCCC		35.3029996109
1043PhosphorylationKSSLHKRSAELSRNN
CCHHHHHHHHHHCCC		30.7929996109
1047PhosphorylationHKRSAELSRNNSPRP
HHHHHHHHCCCCCCC		25.1921712547
1051PhosphorylationAELSRNNSPRPDFLP
HHHHCCCCCCCCCCC		26.3225720772
1067PhosphorylationPNQPLLHSNLHSPVS
CCCCCCCCCCCCCCC		40.8529996109
1071PhosphorylationLLHSNLHSPVSPVVD
CCCCCCCCCCCCCCC		30.1129996109
1074PhosphorylationSNLHSPVSPVVDSNE
CCCCCCCCCCCCCCC		18.5029996109
1138PhosphorylationEKLGDVLTDEYRHLK
EEHHHHHHHHCHHHH		27.0021712547
1141PhosphorylationGDVLTDEYRHLKEFK
HHHHHHHCHHHHHCC		13.2221712547
1544PhosphorylationSWLGRTVSRPRLDTV
HHHCCCCCCHHHHHH		35.6325720772
1550PhosphorylationVSRPRLDTVLSSLGS
CCCHHHHHHHHHHHH		28.1225720772
1553PhosphorylationPRLDTVLSSLGSKFS
HHHHHHHHHHHHHHH		21.1225720772
1554PhosphorylationRLDTVLSSLGSKFSK
HHHHHHHHHHHHHHH		32.3729996109
1587PhosphorylationGPFGKVASQKNLTVQ
CCCCCCCCCCCCEEE		44.6827738172
1613PhosphorylationYSDRPTSSGPSYQNR
HCCCCCCCCCCCCCC		58.1429996109
1634PhosphorylationESMNMGVYSPYRRST
CHHCCCCCCCCCCHH		9.7429996109
1635PhosphorylationSMNMGVYSPYRRSTE
HHCCCCCCCCCCHHH		17.0429996109
1637PhosphorylationNMGVYSPYRRSTEIA
CCCCCCCCCCHHHHH		16.8429996109
1641PhosphorylationYSPYRRSTEIAENMS
CCCCCCHHHHHHHCC		29.6025720772
1995PhosphorylationYVDVMRNS-------
HHHHHCCC-------		31.1024763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEC16_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEC16_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEC16_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SEC16_SCHPO !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEC16_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-790, AND MASSSPECTROMETRY.

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