SDE3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDE3_ARATH
• UniProt AC: Q8GYD9
• Protein Name: Probable RNA helicase SDE3
• Gene Name: SDE3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1002
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable RNA helicase required for post-transcriptional gene silencing (PTGS), a process that provides protection in plants against virus infection and can suppress expression of transgenes. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation. Involved in the amplification of sense-PTGS (S-PTGS), leading to siRNA production. Required for the maintenance but not the initiation of tobacco rattle virus (TRV)-mediated silencing, probably by mediating/maintaining DNA methylation and chromatin-based transcriptional gene silencing at some genomic locations..
• Protein Sequence: MSVSGYKSDDEYSVIADKGEIGFIDYQNDGSSGCYNPFDEGPVVVSVPFPFKKEKPQSVTVGETSFDSFTVKNTMDEPVDLWTKIYASNPEDSFTLSILKPPSKDSDLKERQCFYETFTLEDRMLEPGDTLTIWVSCKPKDIGLHTTVVTVDWGSDRVERVVFLLAEDKISSSLTSNRPYSRSRRAPKKDFAVDDYVKGSRPSKVVERSFRNRLPLYEIPKEIREMIENKEFPDDLNEGLTARNYANYYKTLLIMEELQLEEDMRAYDMENVSMKRRGIYLSLEVPGLAERRPSLVHGDFIFVRHAYDDGTDHAYQGFVHRVEADEVHMKFASEFHQRHTAGSVYNVRFTYNRINTRRLYQAVDAAEMLDPNFLFPSLHSGKRMIKTKPFVPISPALNAEQICSIEMVLGCKGAPPYVIHGPPGTGKTMTLVEAIVQLYTTQRNARVLVCAPSNSAADHILEKLLCLEGVRIKDNEIFRLNAATRSYEEIKPEIIRFCFFDELIFKCPPLKALTRYKLVVSTYMSASLLNAEGVNRGHFTHILLDEAGQASEPENMIAVSNLCLTETVVVLAGDPRQLGPVIYSRDAESLGLGKSYLERLFECDYYCEGDENYVTKLVKNYRCHPEILDLPSKLFYDGELVASKEDTDSVLASLNFLPNKEFPMVFYGIQGCDEREGNNPSWFNRIEISKVIETIKRLTANDCVQEEDIGVITPYRQQVMKIKEVLDRLDMTEVKVGSVEQFQGQEKQVIIISTVRSTIKHNEFDRAYCLGFLSNPRRFNVAITRAISLLVIIGNPHIICKDMNWNKLLWRCVDNNAYQGCGLPEQEEFVEEPFKQEGSSNGPQYPPEAEWNNSGELNNGGANENGEWSDGWNNNGGTKEKNEWSDGWNSNGGGTKKKDEWSDGWDNNGGTNGINQEGSSNAPQDPQEAEWNDSGEVKNGGTKEKDVRSDGWNNNGGKNEKEECCDGWKDGGSGEEIKNGGKFETRGDFVAKEEDEWSDGWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSVSGYKSDDEYSVI CCCCCCCCCCCCEEE	41.64	19880383
667	Phosphorylation	KEFPMVFYGIQGCDE CCCCEEEEEEECCCC	11.25	19880383
885	Phosphorylation	TKEKNEWSDGWNSNG CCCCCCCCCCCCCCC	21.77	19245862
890	Phosphorylation	EWSDGWNSNGGGTKK CCCCCCCCCCCCCCC	30.28	19245862
895	Phosphorylation	WNSNGGGTKKKDEWS CCCCCCCCCCCCCCC	42.86	19245862
973	Phosphorylation	DGWKDGGSGEEIKNG CCCCCCCCCCCCCCC	48.86	19880383
998	Phosphorylation	AKEEDEWSDGWK--- ECCCCCCCCCCC---	24.97	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDE3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDE3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDE3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of SDE3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.