SCYL1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCYL1_RAT
• UniProt AC: Q5M9F8
• Protein Name: N-terminal kinase-like protein
• Gene Name: Scyl1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 807
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF
• Protein Description: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro..
• Protein Sequence: MWFFARDPVRDFPFELNPEPPEGGPPGPWVLHRGRKKATGSAVSIFVYDVKPGAEEQTQVAKAAFKRLKTLRHPNILAYIDGLETEKCLHIVTEAVTPLGTYLKARAEAGGLKEQELSWGLHQIVKALSFLVNDCNLIHNNVCMAAVFVDKAGEWKLGGLDYMYSAQGNGGGPPNKGIPELEQYDPPELADSSSRAVKEKWSADMWRLGCLIWEVFNGSLPRATALRNPGKIPKSLVTHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDSFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRVRLLQQMEQFIQYLDEPTVNTQIFPHVTHGFLDTNPAIREQTVKSMLLLAPKLSETNLNVELLKHFARLQAKDDQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATKDPFAPSRVAGVLGFAATHNLYSMDDCAHKILPVLCGLTVDPEKSVRDQAFKTIRSFLSKLESVSEDPTQLAEIEKDVHAASSPGTGGAAASWAGWAVTGVSSLTSKLIRTHPTPVPSEAAVPQRPVPEGDPAPAPAPASATPATSGHRETQEEDKDAAEDSATADRWDDEDWGSLEQEAESVLAQQDDWSTKGQGNRAGQVSHSDHKSLDSHWSSWEVEGSWDQGWQEPSSVEPPPEGTRLASEYNWGGAEPSDKGDPFAALSVRPSTQPRPDPDSWGEDNWEGLEAESRQVKAELARKKREERRREMEAKRAEKKATKGPMKLGARKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	HRGRKKATGSAVSIF ECCCCCCCCCEEEEE		16641100
41	Phosphorylation	GRKKATGSAVSIFVY CCCCCCCCEEEEEEE		16641100
44	Phosphorylation	KATGSAVSIFVYDVK CCCCCEEEEEEEECC		16641100
48	Phosphorylation	SAVSIFVYDVKPGAE CEEEEEEEECCCCHH		16641100
70	Phosphorylation	AAFKRLKTLRHPNIL HHHHHHHHCCCCCCC		23984901
460	Phosphorylation	GKIGSYLSASTRHRV HHHHHHCCHHHHHHH		23984901
462	Phosphorylation	IGSYLSASTRHRVLT HHHHCCHHHHHHHHH		23984901
463	Phosphorylation	GSYLSASTRHRVLTS HHHCCHHHHHHHHHH		23984901
558	Phosphorylation	EKDVHAASSPGTGGA HHHHHHHCCCCCCCH		23984901
559	Phosphorylation	KDVHAASSPGTGGAA HHHHHHCCCCCCCHH		23984901
562	Phosphorylation	HAASSPGTGGAAASW HHHCCCCCCCHHHHH		23984901
568	Phosphorylation	GTGGAAASWAGWAVT CCCCHHHHHHHHHHH		23984901
575	Phosphorylation	SWAGWAVTGVSSLTS HHHHHHHHCHHHHHH		23984901
578	Phosphorylation	GWAVTGVSSLTSKLI HHHHHCHHHHHHHHH		26022182
579	Phosphorylation	WAVTGVSSLTSKLIR HHHHCHHHHHHHHHH		26022182
581	Phosphorylation	VTGVSSLTSKLIRTH HHCHHHHHHHHHHCC		26022182
582	Phosphorylation	TGVSSLTSKLIRTHP HCHHHHHHHHHHCCC		26022182
753	Phosphorylation	QPRPDPDSWGEDNWE CCCCCCCCCCCCCCH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCYL1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCYL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCYL1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SCYL1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.