SCOT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCOT1_MOUSE
• UniProt AC: Q9D0K2
• Protein Name: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
• Gene Name: Oxct1
• Organism: Mus musculus (Mouse).
• Sequence Length: 520
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)..
• Protein Sequence: MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Acetylation	VSTRHHTKFYTDPVE EECCCCCEEECCHHH	31.83	51084319
43	Nitration	TRHHTKFYTDPVEAV CCCCCEEECCHHHHH	16.28	-
83	Succinylation	ALLKTGVKDLTAVSN HHHHHCCCHHHHHCC	48.65	26388266
115	Nitration	IKRMISSYVGENAEF HHHHHHHHCCCCHHH	12.99	-
115	Phosphorylation	IKRMISSYVGENAEF HHHHHHHHCCCCHHH	12.99	25195567
170	Phosphorylation	TLVQEGGSPIKYNKD EEEEECCCCCEECCC	34.02	28066266
176	Acetylation	GSPIKYNKDGSVAIA CCCCEECCCCCEEEE	61.45	66704063
185	Acetylation	GSVAIASKPREVREF CCEEEECCCCEEEEE	38.79	24062335
185	Succinylation	GSVAIASKPREVREF CCEEEECCCCEEEEE	38.79	-
185	Succinylation	GSVAIASKPREVREF CCEEEECCCCEEEEE	38.79	23806337
283	Phosphorylation	EKRIERLSLRKEGDG HHHHHHHCCCCCCCC	32.14	24704852
293	Acetylation	KEGDGKGKSGKPGGD CCCCCCCCCCCCCCH	60.57	2394965
294	Phosphorylation	EGDGKGKSGKPGGDV CCCCCCCCCCCCCHH	61.80	23684622
296	Acetylation	DGKGKSGKPGGDVRE CCCCCCCCCCCHHHH	47.80	2394973
407	Phosphorylation	GAMQVSKYGDLANWM CCEEHHHCCCHHCCC	14.36	25195567
418	Succinylation	ANWMIPGKMVKGMGG HCCCCCCCCCCCCCH	34.86	23806337
418	Succinylation	ANWMIPGKMVKGMGG HCCCCCCCCCCCCCH	34.86	-
418	Acetylation	ANWMIPGKMVKGMGG HCCCCCCCCCCCCCH	34.86	24062335
421	Ubiquitination	MIPGKMVKGMGGAMD CCCCCCCCCCCHHHH	39.42	-
421	Succinylation	MIPGKMVKGMGGAMD CCCCCCCCCCCHHHH	39.42	-
421	Acetylation	MIPGKMVKGMGGAMD CCCCCCCCCCCHHHH	39.42	24062335
421	Succinylation	MIPGKMVKGMGGAMD CCCCCCCCCCCHHHH	39.42	23806337
455	Succinylation	NAHKIMEKCTLPLTG CHHHHHHHCCCCCCC	18.35	-
455	Succinylation	NAHKIMEKCTLPLTG CHHHHHHHCCCCCCC	18.35	23806337
455	Acetylation	NAHKIMEKCTLPLTG CHHHHHHHCCCCCCC	18.35	24062335
456	Glutathionylation	AHKIMEKCTLPLTGK HHHHHHHCCCCCCCH	2.77	24333276
456	S-nitrosylation	AHKIMEKCTLPLTGK HHHHHHHCCCCCCCH	2.77	21278135
456	S-nitrosocysteine	AHKIMEKCTLPLTGK HHHHHHHCCCCCCCH	2.77	-
473	Acetylation	VNRIITEKGVFDVDK HHHHHHCCCCEEECC	52.29	23236377
480	Acetylation	KGVFDVDKKNGLTLI CCCEEECCCCCEEEE	48.24	2394989
504	S-nitrosocysteine	DIKKSTGCDFAVSPN HHHHHCCCCEEECCC	3.84	-
504	S-nitrosylation	DIKKSTGCDFAVSPN HHHHHCCCCEEECCC	3.84	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCOT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCOT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCOT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SCOT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.