SCNM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCNM1_MOUSE
• UniProt AC: Q8K136
• Protein Name: Sodium channel modifier 1
• Gene Name: Scnm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 229
• Subcellular Localization: Nucleus. Nucleus speckle. Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.
• Protein Description: Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites..
• Protein Sequence: MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHRPEAPAPSVSSPPLPTAEVQLQSAEISKEPEPRERSDAKESAALLASAPMSPTKRRVLNHYLTLRSSGWVPDGRGRWIKDENVEFDSDEEEPPDLPLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFKREGDD ------CCCCCCCCC	39.20	23984901
11	Phosphorylation	KREGDDWSQLNVLKK CCCCCCHHHHHHHHH	31.61	23984901
125	Phosphorylation	HRAPHYNSCCRRKHR HHCCCCCCHHCCCCC	13.87	27149854
139	Phosphorylation	RPEAPAPSVSSPPLP CCCCCCCCCCCCCCC	36.42	26643407
141	Phosphorylation	EAPAPSVSSPPLPTA CCCCCCCCCCCCCCC	41.27	25266776
142	Phosphorylation	APAPSVSSPPLPTAE CCCCCCCCCCCCCCE	28.51	26643407
147	Phosphorylation	VSSPPLPTAEVQLQS CCCCCCCCCEEEEHH	43.03	26643407
154	Phosphorylation	TAEVQLQSAEISKEP CCEEEEHHCCCCCCC	36.14	26643407
158	Phosphorylation	QLQSAEISKEPEPRE EEHHCCCCCCCCCCC	23.59	26643407
172	Phosphorylation	ERSDAKESAALLASA CCCCHHHHHHHHHCC	20.38	28833060
178	Phosphorylation	ESAALLASAPMSPTK HHHHHHHCCCCCHHH	32.64	28833060
182	Phosphorylation	LLASAPMSPTKRRVL HHHCCCCCHHHHHHH	28.49	25521595
184	Phosphorylation	ASAPMSPTKRRVLNH HCCCCCHHHHHHHHH	29.85	22942356
218	Phosphorylation	DENVEFDSDEEEPPD CCCCCCCCCCCCCCC	52.85	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCNM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCNM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCNM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SCNM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.