| UniProt ID | SCN3B_RAT | |
|---|---|---|
| UniProt AC | Q9JK00 | |
| Protein Name | Sodium channel subunit beta-3 | |
| Gene Name | Scn3b | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 215 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.. | |
| Protein Sequence | MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | N-linked_Glycosylation | FQGRLQWNGSKDLQD CCCCCCCCCCCCCCE | 31.72 | - | |
| 109 | N-linked_Glycosylation | DVSITVLNVTLNDSG EEEEEEEEEEECCCC | 22.01 | - | |
| 113 | N-linked_Glycosylation | TVLNVTLNDSGLYTC EEEEEEECCCCCEEE | 31.85 | - | |
| 121 | N-linked_Glycosylation | DSGLYTCNVSREFEF CCCCEEECCCEEEEE | 27.31 | - | |
| 186 | Ubiquitination | YCYRKVSKAEEAAQE HHHHHHHHHHHHHHH | 63.91 | - | |
| 196 | Phosphorylation | EAAQENASDYLAIPS HHHHHCCHHCCCCCC | 38.07 | 28551015 | |
| 198 | Phosphorylation | AQENASDYLAIPSEN HHHCCHHCCCCCCCC | 8.78 | 28551015 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCN3B_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCN3B_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCN3B_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SCN3B_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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