SCN2B_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCN2B_RAT
• UniProt AC: P54900
• Protein Name: Sodium channel subunit beta-2
• Gene Name: Scn2b
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 215
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier..
• Protein Sequence: MHRDAWLPRPAFSLTGLSLFFSLVPSGRSMEVTVPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	PTTLSVLNGSDTRLP CCEEEECCCCCCCCC	45.85	-
66	N-linked_Glycosylation	NHKQFSLNWTYQECS CCCEEEEEEEEHHCC	28.04	-
74	N-linked_Glycosylation	WTYQECSNCSEEMFL EEEHHCCCCCHHHHH	45.02	-
108	Phosphorylation	FSGNPSKYDVSVTLK ECCCCCCCEEEEEEE	26.39	-
111	Phosphorylation	NPSKYDVSVTLKNVQ CCCCCEEEEEEECEE	13.39	-
192	Phosphorylation	RKKEQKLSTDDLKTE HHHHHCCCHHHCCCH	36.50	25403869
197	Ubiquitination	KLSTDDLKTEEEGKT CCCHHHCCCHHCCCC	61.97	-
198	Phosphorylation	LSTDDLKTEEEGKTD CCHHHCCCHHCCCCC	56.79	25403869
203	Ubiquitination	LKTEEEGKTDGEGNA CCCHHCCCCCCCCCC	46.88	-
204	Phosphorylation	KTEEEGKTDGEGNAE CCHHCCCCCCCCCCC	61.16	30411139

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCN2B_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCN2B_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCN2B_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of SCN2B_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.