dbPTM

SCN1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SCN1A_HUMAN
UniProt AC	P35498
Protein Name	Sodium channel protein type 1 subunit alpha
Gene Name	SCN1A
Organism	Homo sapiens (Human).
Sequence Length	2009
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli..
Protein Sequence	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
169	Phosphorylation	TGIYTFESLIKIIAR CEEEEHHHHHHHHHH	31.07	24719451
211	N-linked_Glycosylation	TEFVDLGNVSALRTF CCCCCCCCHHHHHHH	31.69	UniProtKB CARBOHYD
225	Ubiquitination	FRVLRALKTISVIPG HHHHHHHHHHCCCCC	42.71	27667366
284	N-linked_Glycosylation	CIQWPPTNASLEEHS CCCCCCCCCCHHHHC	33.05	UniProtKB CARBOHYD
295	N-linked_Glycosylation	EEHSIEKNITVNYNG HHHCCCCCEEECCCC	23.52	UniProtKB CARBOHYD
297	Phosphorylation	HSIEKNITVNYNGTL HCCCCCEEECCCCEE	16.46	29978859
300	Phosphorylation	EKNITVNYNGTLINE CCCEEECCCCEECCE	15.61	29978859
301	N-linked_Glycosylation	KNITVNYNGTLINET CCEEECCCCEECCEE	31.59	UniProtKB CARBOHYD
303	Phosphorylation	ITVNYNGTLINETVF EEECCCCEECCEEEE	22.34	29978859
306	N-linked_Glycosylation	NYNGTLINETVFEFD CCCCEECCEEEEEEC	41.84	UniProtKB CARBOHYD
308	Phosphorylation	NGTLINETVFEFDWK CCEECCEEEEEECHH	26.46	29978859
316	Phosphorylation	VFEFDWKSYIQDSRY EEEECHHHHHCCHHH	24.18	29978859
317	Phosphorylation	FEFDWKSYIQDSRYH EEECHHHHHCCHHHH	10.00	29978859
321	Phosphorylation	WKSYIQDSRYHYFLE HHHHHCCHHHHHHHH	20.54	29978859
338	N-linked_Glycosylation	LDALLCGNSSDAGQC HHHHHCCCCCCCCCC	37.03	UniProtKB CARBOHYD
374	Phosphorylation	TFSWAFLSLFRLMTQ HHHHHHHHHHHHHCH	21.00	24719451
453	Ubiquitination	QMIEQLKKQQEAAQQ HHHHHHHHHHHHHHH	66.85	30230243
470	Phosphorylation	TATASEHSREPSAAG HHHHHHHCCCCCCCC	34.00	-
474	Phosphorylation	SEHSREPSAAGRLSD HHHCCCCCCCCCCCC	26.46	24905233
480	Phosphorylation	PSAAGRLSDSSSEAS CCCCCCCCCCCHHHH	33.80	23911959
482	Phosphorylation	AAGRLSDSSSEASKL CCCCCCCCCHHHHHH	32.18	23911959
483	Phosphorylation	AGRLSDSSSEASKLS CCCCCCCCHHHHHHC	36.87	23911959
487	Phosphorylation	SDSSSEASKLSSKSA CCCCHHHHHHCHHHH	30.03	23403867
490	Phosphorylation	SSEASKLSSKSAKER CHHHHHHCHHHHHHH	39.18	23403867
491	Phosphorylation	SEASKLSSKSAKERR HHHHHHCHHHHHHHH	40.86	23403867
510	Phosphorylation	KRKQKEQSGGEEKDE HHHHHHHCCCCCCCH	50.27	25307156
523	Phosphorylation	DEDEFQKSESEDSIR CHHHHHHCCCHHHHH	35.26	25307156
525	Phosphorylation	DEFQKSESEDSIRRK HHHHHCCCHHHHHHH	54.52	-
544	Phosphorylation	SIEGNRLTYEKRYSS EEECCCCEEEECCCC	26.79	26074081
545	Phosphorylation	IEGNRLTYEKRYSSP EECCCCEEEECCCCC	24.84	26074081
549	Phosphorylation	RLTYEKRYSSPHQSL CCEEEECCCCCCHHH	25.27	26074081
550	Phosphorylation	LTYEKRYSSPHQSLL CEEEECCCCCCHHHH	41.23	26074081
551	Phosphorylation	TYEKRYSSPHQSLLS EEEECCCCCCHHHHH	19.91	26074081
555	Phosphorylation	RYSSPHQSLLSIRGS CCCCCCHHHHHHHCC	28.39	26074081
558	Phosphorylation	SPHQSLLSIRGSLFS CCCHHHHHHHCCCCC	18.61	26074081
562	Phosphorylation	SLLSIRGSLFSPRRN HHHHHHCCCCCCCCC	19.18	26074081
565	Phosphorylation	SIRGSLFSPRRNSRT HHHCCCCCCCCCCCC	23.84	32142685
576	Phosphorylation	NSRTSLFSFRGRAKD CCCCCCEEECCCCCC	21.23	24719451
586	Phosphorylation	GRAKDVGSENDFADD CCCCCCCCCCCCCCC	32.83	-
607	Phosphorylation	DNESRRDSLFVPRRH CCCHHHHCCCCCCCC	23.15	-
643	Phosphorylation	PANGKMHSTVDCNGV ECCCCEEEEEECCCE	26.99	-
644	Phosphorylation	ANGKMHSTVDCNGVV CCCCEEEEEECCCEE	12.99	-
652 (in isoform 3)	Phosphorylation	-	18.22	-
655 (in isoform 3)	Phosphorylation	-	47.81	22210691
656 (in isoform 3)	Phosphorylation	-	12.11	22210691
693	Phosphorylation	ETEMRKRRSSSFHVS HHHHHHHHHCCCEEC	43.88	32142685
710	Phosphorylation	FLEDPSQRQRAMSIA HHCCHHHHHHHHHHH	32.08	32142685
718	Phosphorylation	QRAMSIASILTNTVE HHHHHHHHHHHHHHH	19.23	26434776
721	Phosphorylation	MSIASILTNTVEELE HHHHHHHHHHHHHHH	27.46	26434776
723	Phosphorylation	IASILTNTVEELEES HHHHHHHHHHHHHHH	24.86	26434776
730	Phosphorylation	TVEELEESRQKCPPC HHHHHHHHHHHCCCC	30.54	-
856	Phosphorylation	LANVEGLSVLRSFRL CCCCCCHHHHHHHHH	29.93	24719451
860	Phosphorylation	EGLSVLRSFRLLRVF CCHHHHHHHHHHHHH	15.57	-
1037	Phosphorylation	IYEFIQQSFIRKQKI HHHHHHHHHHHHHHH	13.28	24719451
1060	Phosphorylation	DLNNKKDSCMSNHTA HCCCCCCCHHHHHHH	22.16	-
1063	Phosphorylation	NKKDSCMSNHTAEIG CCCCCHHHHHHHHHC	29.77	-
1066	Phosphorylation	DSCMSNHTAEIGKDL CCHHHHHHHHHCCCH	30.18	-
1378	N-linked_Glycosylation	GKFYHCINTTTGDRF HHHHHECCCCCCCCC	36.45	UniProtKB CARBOHYD
1392	N-linked_Glycosylation	FDIEDVNNHTDCLKL CCHHHCCCCCHHHHH	39.00	UniProtKB CARBOHYD
1403	N-linked_Glycosylation	CLKLIERNETARWKN HHHHHHHCCCCCCCC	37.87	UniProtKB CARBOHYD
1506	Acetylation	FMTEEQKKYYNAMKK CCCHHHHHHHHHHHH	53.30	30592201
1507	Phosphorylation	MTEEQKKYYNAMKKL CCHHHHHHHHHHHHH	14.69	22817900
1508	Phosphorylation	TEEQKKYYNAMKKLG CHHHHHHHHHHHHHC	12.81	22817900
1516	Phosphorylation	NAMKKLGSKKPQKPI HHHHHHCCCCCCCCC	48.20	10532948
1562	Phosphorylation	MVTMMVETDDQSEYV HHHHCCCCCCCHHHH	33.20	22210691
1566	Phosphorylation	MVETDDQSEYVTTIL CCCCCCCHHHHHHHH	37.58	22210691
1631	Phosphorylation	LIEKYFVSPTLFRVI HHHHHCCCHHHHHHH	11.41	28348404
1633	Phosphorylation	EKYFVSPTLFRVIRL HHHCCCHHHHHHHHH	30.90	28348404
1684	Phosphorylation	LFLVMFIYAIFGMSN HHHHHHHHHHHCCCC	5.16	-
1694	Phosphorylation	FGMSNFAYVKREVGI HCCCCHHHHCCHHCC	11.45	-
1908	Phosphorylation	VSYQPITTTLKRKQE CCCCCCCHHHHHCHH	30.74	-
1909	Phosphorylation	SYQPITTTLKRKQEE CCCCCCHHHHHCHHH	22.95	-
1918	Phosphorylation	KRKQEEVSAVIIQRA HHCHHHHHHHHHHHH	21.79	19413330
1926	Phosphorylation	AVIIQRAYRRHLLKR HHHHHHHHHHHHHHH	15.46	-
1934	Phosphorylation	RRHLLKRTVKQASFT HHHHHHHHHHHHHCC	30.39	-
1936	Acetylation	HLLKRTVKQASFTYN HHHHHHHHHHHCCCC	39.26	19826715
1939	Phosphorylation	KRTVKQASFTYNKNK HHHHHHHHCCCCCCC	18.67	-
1946	Acetylation	SFTYNKNKIKGGANL HCCCCCCCCCCCCEE	47.61	19826723
1948	Acetylation	TYNKNKIKGGANLLI CCCCCCCCCCCEEEE	53.56	7721043
1990	Phosphorylation	PPSYDRVTKPIVEKH CCCCCCCCHHHHHHH	31.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1516	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1516	S	Phosphorylation		-
Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SCN1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SCN1A_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SCN1A_HUMAN

Related Literatures of Post-Translational Modification

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