SCIMP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCIMP_HUMAN
• UniProt AC: Q6UWF3
• Protein Name: SLP adapter and CSK-interacting membrane protein
• Gene Name: SCIMP
• Organism: Homo sapiens (Human).
• Sequence Length: 145
• Subcellular Localization: Membrane ; Single-pass membrane protein . Membrane ; Lipid-anchor . Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell c
• Protein Description: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation..
• Protein Sequence: MDTFTVQDSTAMSWWRNNFWIILAVAIIVVSVGLGLILYCVCKWQLRRGKKWEIAKPLKHKQVDEEKMYENVLNESPVQLPPLPPRNWPSLEDSSPQEAPSQPPATYSLVNKVKNKKTVSIPSYIEPEDDYDDVEIPANTEKASF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTFTVQDST -----CCCEECCCCH	21.65	22210691
5	Phosphorylation	---MDTFTVQDSTAM ---CCCEECCCCHHH	21.25	22210691
10	Phosphorylation	TFTVQDSTAMSWWRN CEECCCCHHHHHHHH	34.37	22210691
13	Phosphorylation	VQDSTAMSWWRNNFW CCCCHHHHHHHHHHH	22.48	22210691
40	S-palmitoylation	GLGLILYCVCKWQLR HHHHHHHHHHHHHHH	2.31	21930792
42	S-palmitoylation	GLILYCVCKWQLRRG HHHHHHHHHHHHHCC	3.11	21930792
69	Phosphorylation	QVDEEKMYENVLNES CCCHHHHHHHHHCCC	18.54	21930792
76	Phosphorylation	YENVLNESPVQLPPL HHHHHCCCCCCCCCC	29.33	30108239
90	Phosphorylation	LPPRNWPSLEDSSPQ CCCCCCCCCCCCCCC	35.69	24719451
94	Phosphorylation	NWPSLEDSSPQEAPS CCCCCCCCCCCCCCC	34.25	28450419
95	Phosphorylation	WPSLEDSSPQEAPSQ CCCCCCCCCCCCCCC	42.81	28450419
101	Phosphorylation	SSPQEAPSQPPATYS CCCCCCCCCCCCCHH	63.47	28348404
106	Phosphorylation	APSQPPATYSLVNKV CCCCCCCCHHHHHHC	21.29	28348404
107	Phosphorylation	PSQPPATYSLVNKVK CCCCCCCHHHHHHCC	11.34	21930792
108	Phosphorylation	SQPPATYSLVNKVKN CCCCCCHHHHHHCCC	22.83	28348404
123	Phosphorylation	KKTVSIPSYIEPEDD CCCCCCCCCCCCCCC	36.75	28348404
124	Phosphorylation	KTVSIPSYIEPEDDY CCCCCCCCCCCCCCC	12.16	-
131	Phosphorylation	YIEPEDDYDDVEIPA CCCCCCCCCCCCCCC	26.77	21930792
140	Phosphorylation	DVEIPANTEKASF-- CCCCCCCCCCCCC--	40.75	30108239
144	Phosphorylation	PANTEKASF------ CCCCCCCCC------	42.42	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCIMP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCIMP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCIMP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SCIMP_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.