SCAF8_MOUSE - dbPTM
SCAF8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCAF8_MOUSE
UniProt AC Q6DID3
Protein Name Protein SCAF8
Gene Name Scaf8
Organism Mus musculus (Mouse).
Sequence Length 1268
Subcellular Localization Nucleus . Nucleus matrix . Detected in granular nuclear foci which correspond to sites of active transcription.
Protein Description May play a role in mRNA processing..
Protein Sequence MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQIANTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFNKKLMDRFDFGEDSEHSEESKKEMPTPQLSHVSESVNNSIFHQIAEQLQQQNLEQLRQQLLEQQQPQKVTPQDSQEGTFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEGQDVVEEEIFEPEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSHSREKKRKASRSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLDGFAEGGMIDQETVNAEWETVKASEPVKEPVQTAQSPAPVEKESVVTTQAEVFPPPVAMLQIPVAPAVPAVSLVPPAFPVSMPVPPPGFNPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPAIPPVVPTSLVQPPLSMTPEAVKDVGFGSLVLPSGSVAGSLAPSTLPAGNVFNPPSKAEPEEKVPHLIEHQIPSGENTRPVIPSDIPSSAAMLAQPPGASSTSGILCVQRPNVSSNSEILGVRPANVSNSAAIMGAQPPNILNNSGILAIQPPNVSSGSGLLGVLPPNLPNNSGLVGLQPPNVTSPAGLLGTQPPIGPQNLPPLAIPAQRMPALPMLDIRPGLIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFPPGDLFSQPERPFLAPGRPSIDNVPNPDKRIPLGNDNIQQEGDRDYRFPPIETREGITRPPQVDVRDVVGRRLDPREGPGRPPLDARDHFGRPPVDMRENLVRPSLDHLGRRDHFGFPPEKPWGPRDFDEREHRVLPVFGGPKGLHEERGRFRAGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREINGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGDNVPQVNGENTERHAQPPPLPVQKDPELYEKLASSGDVDKEESGTVAGVESEAVVESTETEGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MEAVKTFNSELYS
--CCHHHHHCHHHHH		22.81-
273PhosphorylationRFDFGEDSEHSEESK
CCCCCCCCCCCHHHH		32.6722817900
276PhosphorylationFGEDSEHSEESKKEM
CCCCCCCCHHHHHHC		38.7222817900
279PhosphorylationDSEHSEESKKEMPTP
CCCCCHHHHHHCCCC		45.0028066266
408PhosphorylationRTHSRSRSRSPRKRR
CCCCCCCCCCCCHHH		38.0519854140
410PhosphorylationHSRSRSRSPRKRRSR
CCCCCCCCCCHHHHC		30.2419854140
445PhosphorylationKKRKASRSYSSERRA
HHHHHHHHHHHHHHH		27.2029514104
446PhosphorylationKRKASRSYSSERRAR
HHHHHHHHHHHHHHH		18.3322802335
447PhosphorylationRKASRSYSSERRARE
HHHHHHHHHHHHHHH		27.2823737553
448PhosphorylationKASRSYSSERRARER
HHHHHHHHHHHHHHH		27.2123737553
605PhosphorylationEWETVKASEPVKEPV
EEEEEECCCCCCCCC		36.3925619855
614PhosphorylationPVKEPVQTAQSPAPV
CCCCCCCCCCCCCCC		27.2224925903
617PhosphorylationEPVQTAQSPAPVEKE
CCCCCCCCCCCCCCC		22.1424925903
915MethylationPLAIPAQRMPALPML
CCCCCCCCCCCCCCC		34.85-
915Asymmetric dimethylargininePLAIPAQRMPALPML
CCCCCCCCCCCCCCC		34.85-
925MethylationALPMLDIRPGLIAQA
CCCCCCCCCCEEECC		20.92-
925Asymmetric dimethylarginineALPMLDIRPGLIAQA
CCCCCCCCCCEEECC		20.92-
936MethylationIAQAPGPRFPLLQPG
EECCCCCCCCCCCCC		52.2918962927
936Asymmetric dimethylarginineIAQAPGPRFPLLQPG
EECCCCCCCCCCCCC		52.29-
1071MethylationDMRENLVRPSLDHLG
CCHHHCCCCCHHHCC		20.4624129315
1071Asymmetric dimethylarginineDMRENLVRPSLDHLG
CCHHHCCCCCHHHCC		20.46-
1117MethylationPKGLHEERGRFRAGN
CCCHHCCCCCCCCCC		38.3118601191
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCAF8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCAF8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCAF8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SCAF8_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCAF8_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617, AND MASSSPECTROMETRY.

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