| UniProt ID | SC6A9_RAT | |
|---|---|---|
| UniProt AC | P28572 | |
| Protein Name | Sodium- and chloride-dependent glycine transporter 1 | |
| Gene Name | Slc6a9 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 638 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.. | |
| Protein Sequence | MAVAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALSGNLSHLFNYTLQRTSPSEEYWRLYVLKLSDDIGDFGEVRLPLLGCLGVSWVVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTTTPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 169 | N-linked_Glycosylation | AGVLDASNLTNGSRP CCCCCHHHCCCCCCC | 53.24 | - | |
| 172 | N-linked_Glycosylation | LDASNLTNGSRPTAL CCHHHCCCCCCCCCH | 50.00 | - | |
| 182 | N-linked_Glycosylation | RPTALSGNLSHLFNY CCCCHHCCHHHHHHH | 34.69 | - | |
| 188 | N-linked_Glycosylation | GNLSHLFNYTLQRTS CCHHHHHHHCCCCCC | 34.93 | - | |
| 577 | Acetylation | DTLLQRLKNATKPSR HHHHHHHHHCCCCCC | 46.88 | 22902405 | |
| 581 | Acetylation | QRLKNATKPSRDWGP HHHHHCCCCCCCCHH | 38.29 | 22902405 | |
| 581 | Ubiquitination | QRLKNATKPSRDWGP HHHHHCCCCCCCCHH | 38.29 | - | |
| 598 | Phosphorylation | LEHRTGRYAPTTTPS HHHCCCCCCCCCCCC | 20.48 | 28551015 | |
| 601 | Phosphorylation | RTGRYAPTTTPSPED CCCCCCCCCCCCCCC | 34.82 | 27097102 | |
| 602 | Phosphorylation | TGRYAPTTTPSPEDG CCCCCCCCCCCCCCC | 35.33 | 27097102 | |
| 603 | Phosphorylation | GRYAPTTTPSPEDGF CCCCCCCCCCCCCCC | 25.01 | 27097102 | |
| 605 | Phosphorylation | YAPTTTPSPEDGFEV CCCCCCCCCCCCCCC | 38.54 | 27097102 | |
| 627 | Phosphorylation | AQIPIVGSNGSSRLQ CCCCCCCCCCCCCCC | 27.42 | 27097102 | |
| 630 | Phosphorylation | PIVGSNGSSRLQDSR CCCCCCCCCCCCCCC | 19.28 | 23984901 | |
| 631 | Phosphorylation | IVGSNGSSRLQDSRI CCCCCCCCCCCCCCC | 38.11 | 23984901 | |
| 636 | Phosphorylation | GSSRLQDSRI----- CCCCCCCCCC----- | 20.93 | 23984901 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SC6A9_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SC6A9_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SC6A9_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SC6A9_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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