SC6A2_HUMAN - dbPTM
SC6A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SC6A2_HUMAN
UniProt AC P23975
Protein Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Organism Homo sapiens (Human).
Sequence Length 617
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals..
Protein Sequence MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29UbiquitinationEQPLRARKTAELLVV
CCCCHHHCEEEEEEE		51.61-
30PhosphorylationQPLRARKTAELLVVK
CCCHHHCEEEEEEEE		21.5821498515
37UbiquitinationTAELLVVKERNGVQC
EEEEEEEEECCCEEE		43.40-
84AcetylationANVWRFPYLCYKNGG
HHCCCCCEEECCCCC		13.4919413330
99UbiquitinationGAFLIPYTLFLIIAG
CEEEEEHHHHHHHHC		12.99-
101UbiquitinationFLIPYTLFLIIAGMP
EEEEHHHHHHHHCCC		3.38-
184N-linked_GlycosylationGHTWNSPNCTDPKLL
CCCCCCCCCCCHHHC		40.93UniProtKB CARBOHYD
189AcetylationSPNCTDPKLLNGSVL
CCCCCCHHHCCCCCC		69.3019413330
192N-linked_GlycosylationCTDPKLLNGSVLGNH
CCCHHHCCCCCCCCC		51.64UniProtKB CARBOHYD
194PhosphorylationDPKLLNGSVLGNHTK
CHHHCCCCCCCCCCC		17.0719413330
198N-linked_GlycosylationLNGSVLGNHTKYSKY
CCCCCCCCCCCCCCC		35.18UniProtKB CARBOHYD
200PhosphorylationGSVLGNHTKYSKYKF
CCCCCCCCCCCCCCC		35.3622673903
202PhosphorylationVLGNHTKYSKYKFTP
CCCCCCCCCCCCCCC		16.1422673903
203PhosphorylationLGNHTKYSKYKFTPA
CCCCCCCCCCCCCCH		30.9422673903
204UbiquitinationGNHTKYSKYKFTPAA
CCCCCCCCCCCCCHH		49.74-
206UbiquitinationHTKYSKYKFTPAAEF
CCCCCCCCCCCHHHH		46.64-
258PhosphorylationSLWKGVKTSGKVVWI
HHHCCCCCCCCEEEE		40.0616740633
259PhosphorylationLWKGVKTSGKVVWIT
HHCCCCCCCCEEEEE		30.7916740633
351S-nitrosocysteineLLTSSINCITSFVSG
HHHHHHHHHHHHHHH		3.24-
351S-nitrosylationLLTSSINCITSFVSG
HHHHHHHHHHHHHHH		3.2422178444
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
30TPhosphorylationKinaseP38AQ16539
PSP
258TPhosphorylationKinasePKCAP17252
PSP
259SPhosphorylationKinasePKCAP17252
PSP
259SPhosphorylationKinasePRKCEQ02156
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SC6A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SC6A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STX1A_HUMANSTX1Aphysical
17032905
SYUA_HUMANSNCAphysical
18331289
ACTB_HUMANACTBphysical
18331289
SYUA_HUMANSNCAphysical
17156375
Drug and Disease Associations
Kegg Disease
H01031 Orthostatic intolerance (OI); Postural tachycardia syndrome (POTS)
OMIM Disease
604715Orthostatic intolerance (OI)
Kegg Drug
D00110 Cocaine (USP); Cocaine (TN)
D00228 Amoxapine (JP16/USP/INN); Asendin (TN)
D00367 Mazindol (JAN/USP/INN); Sanorex (TN)
D00394 Trimipramine (USAN/INN)
D00809 Amitriptyline hydrochloride (JP16/USP); Elavil (TN)
D00811 Clomipramine hydrochloride (JP16/USP); Anafranil (TN)
D00812 Desipramine hydrochloride (JAN/USP); Norpramin (TN)
D00815 Imipramine hydrochloride (JP16/USP); Tofranil (TN)
D00816 Nortriptyline hydrochloride (JP16/USP/INN); Pamelor (TN)
D00818 Maprotiline hydrochloride (JP16/USP); Ludiomil (TN)
D00821 Venlafaxine hydrochloride (JAN/USAN); Effexor (TN)
D01107 Milnacipran hydrochloride (JAN/USAN); Savella (TN); Toledomin (TN)
D01179 Duloxetine hydrochloride (JAN/USAN); Cymbalta (TN)
D01285 Lofepramine hydrochloride (JAN/USAN); Amplit (TN)
D01546 Dosulepin hydrochloride (JAN); Dothiepin hydrochloride (USAN); Dosulepin (TN)
D02074 Amphetamine sulfate (USP); Benzedrine (TN)
D02078 Dextroamphetamine sulfate (USP); Dexedrine (TN); Dextrostat (TN)
D02182 Cocaine hydrochloride (JP16/USP); Cocaine hydrochloride (TN)
D02242 Methamphetamine hydrochloride (JP16/USP); Desoxyn (TN)
D02408 Trimipramine maleate (JAN/USAN); Surmontil (TN)
D02566 Maprotiline (USAN)
D02570 Desvenlafaxine succinate hydrate (JAN); Desvenlafaxine succinate (USAN); Pristiq (TN)
D02571 Sibutramine hydrochloride hydrate (JAN); Sibutramine hydrochloride (USAN); Sibutramine hydrochloride
D02572 Viloxazine hydrochloride (USAN); Vivalan (TN)
D02573 Reboxetine mesylate (USAN); Reboxetine mesilate; Vestra (TN)
D02574 Atomoxetine hydrochloride (JAN/USAN); Tomoxetine hydrochloride; Strattera (TN)
D03740 Dextroamphetamine (USAN); Dexamfetamine (INN)
D04747 Lisdexamfetamine dimesylate (USAN); Vyvanse (TN); Elvanse (TN)
D05173 Nisoxetine (USAN/INN)
D05200 Nomifensine maleate (USAN); Merital (TN)
D05663 Pyrovalerone hydrochloride (USAN)
D07334 Imipraminoxide (INN)
D07445 Amfetamine (INN); Amphetamine; Amfetamin (TN)
D07448 Amitriptyline (INN); Laroxyl (TN)
D07449 Amitriptylinoxide (INN)
D07473 Atomoxetine (INN); Tomoxetine
D07727 Clomipramine (INN); Anafranil (TN)
D07791 Desipramine (INN)
D07793 Desvenlafaxine (INN)
D07872 Dosulepin (INN); Dothiepin; Dothep (TN)
D07880 Duloxetine (INN); Yentreve (TN)
D08070 Imipramine (INN); Tofranil (TN)
D08071 Imipramine embonate; Tofranil-pm (TN)
D08130 Lisdexamfetamine (INN)
D08140 Lofepramine (INN)
D08187 Metamfetamine (INN); Methamphetamine
D08222 Milnacipran (INN)
D08288 Nortriptyline (INN); Nortrilen (TN)
D08472 Reboxetine (INN); Edronax (TN)
D08513 Sibutramine (INN); Butramin (TN)
D08670 Venlafaxine (INN); Efectin (TN)
D08673 Viloxazine (INN)
D09340 Esreboxetine (USAN/INN)
D09341 Esreboxetine succinate (USAN)
D09890 Edivoxetine (USAN/INN)
D09891 Edivoxetine hydrochloride (USAN)
D10072 Levomilnacipran (USAN/INN)
D10088 Amitifadine (USAN)
D10089 Amitifadine hydrochloride (USAN)
D10133 Levomilnacipran hydrochloride (USAN)
D10443 Liafensine (USAN)
DrugBank
DB00321Amitriptyline
DB00543Amoxapine
DB00182Amphetamine
DB00289Atomoxetine
DB01156Bupropion
DB01114Chlorphenamine
DB00215Citalopram
DB01242Clomipramine
DB00907Cocaine
DB04840Debrisoquin
DB01151Desipramine
DB06700Desvenlafaxine
DB06701Dexmethylphenidate
DB01576Dextroamphetamine
DB00514Dextromethorphan
DB00937Diethylpropion
DB00988Dopamine
DB01142Doxepin
DB06262Droxidopa
DB00476Duloxetine
DB01363Ephedra
DB01364Ephedrine
DB00696Ergotamine
DB01175Escitalopram
DB01381Ginkgo biloba
DB00226Guanadrel
DB01170Guanethidine
DB00458Imipramine
DB06704Iobenguane
DB01221Ketamine
DB08918Levomilnacipran
DB06707Levonordefrin
DB00408Loxapine
DB00934Maprotiline
DB00579Mazindol
DB01577Methamphetamine
DB00422Methylphenidate
DB06148Mianserin
DB04896Milnacipran
DB00370Mirtazapine
DB01149Nefazodone
DB00368Norepinephrine
DB00540Nortriptyline
DB01173Orphenadrine
DB00715Paroxetine
DB00454Pethidine
DB01579Phendimetrazine
DB00830Phenmetrazine
DB00191Phentermine
DB00344Protriptyline
DB00852Pseudoephedrine
DB00234Reboxetine
DB01105Sibutramine
DB06204Tapentadol
DB00193Tramadol
DB00726Trimipramine
DB00285Venlafaxine
Regulatory Network of SC6A2_HUMAN

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Related Literatures of Post-Translational Modification

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