dbPTM

SC6A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SC6A1_HUMAN
UniProt AC	P30531
Protein Name	Sodium- and chloride-dependent GABA transporter 1
Gene Name	SLC6A1
Organism	Homo sapiens (Human).
Sequence Length	599
Subcellular Localization	Cell membrane Multi-pass membrane protein. Membrane Multi-pass membrane protein. Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity)..
Protein Description	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals..
Protein Sequence	MATNGSKVADGQISTEVSEAPVANDKPKTLVVKVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQAGSSTSKEAYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATNGSKVAD -----CCCCCCCCCC	38.52	24719451
6	Phosphorylation	--MATNGSKVADGQI --CCCCCCCCCCCCC	26.48	20068230
18	Phosphorylation	GQISTEVSEAPVAND CCCCCCCCCCCCCCC	23.08	-
28	2-Hydroxyisobutyrylation	PVANDKPKTLVVKVQ CCCCCCCCEEEEEEE	61.30	-
107	Phosphorylation	LECSLGQYTSIGGLG HHCCCCCCCCCCCCC	10.72	11555659
176	N-linked_Glycosylation	NTDRCFSNYSMVNTT CCCCCCCCCCCEECC	16.79	UniProtKB CARBOHYD
176	N-linked_Glycosylation	NTDRCFSNYSMVNTT CCCCCCCCCCCEECC	16.79	8995422
181	N-linked_Glycosylation	FSNYSMVNTTNMTSA CCCCCCEECCCCHHH	32.32	UniProtKB CARBOHYD
181	N-linked_Glycosylation	FSNYSMVNTTNMTSA CCCCCCEECCCCHHH	32.32	8995422
184	N-linked_Glycosylation	YSMVNTTNMTSAVVE CCCEECCCCHHHHHH	29.69	UniProtKB CARBOHYD
184	N-linked_Glycosylation	YSMVNTTNMTSAVVE CCCEECCCCHHHHHH	29.69	8995422
317	Phosphorylation	NSFHNNVYRDSIIVC CCCCCCCCCCCEEEE	15.72	11555659
562	Phosphorylation	MFLTLKGSLKQRIQV HHHHHCCCHHHHEEE	30.70	24719451
591	Phosphorylation	PEQPQAGSSTSKEAY CCCCCCCCCCCCCCC	33.20	24076635
593	Phosphorylation	QPQAGSSTSKEAYI- CCCCCCCCCCCCCC-	45.58	25307156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SC6A1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SC6A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SC6A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
STX1A_HUMAN	STX1A	physical	11960023
STX1A_HUMAN	STX1A	physical	11017172

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616421	Myoclonic-atonic epilepsy (MAE)
Kegg Drug
D02097	Tiagabine hydrochloride (USP); Gabitril (TN)
D08588	Tiagabine (INN); Gabitril (TN)
DrugBank
DB00349	Clobazam
DB00906	Tiagabine

Regulatory Network of SC6A1_HUMAN

Related Literatures of Post-Translational Modification