SC5A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC5A1_HUMAN
• UniProt AC: P13866
• Protein Name: Sodium/glucose cotransporter 1
• Gene Name: SLC5A1
• Organism: Homo sapiens (Human).
• Sequence Length: 664
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules..
• Protein Sequence: MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDSSTWSPKTTAVT -CCCCCCCCCCCCCC	19.33	24719451
10	O-linked_Glycosylation	SSTWSPKTTAVTRPV CCCCCCCCCCCCCCC	24.30	OGP
14	O-linked_Glycosylation	SPKTTAVTRPVETHE CCCCCCCCCCCCHHH	27.13	OGP
19	Phosphorylation	AVTRPVETHELIRNA CCCCCCCHHHHHHHH	22.38	22210691
35	Phosphorylation	DISIIVIYFVVVMAV HHHHHHHHHHHHHHH	4.57	22210691
50	Phosphorylation	GLWAMFSTNRGTVGG HHHHHHCCCCCCCCE	20.05	22210691
229	Phosphorylation	AFHEVGGYDAFMEKY HHHHCCCHHHHHHHH	9.73	22468782
236	Phosphorylation	YDAFMEKYMKAIPTI HHHHHHHHHHHCCEE	7.19	-
242	Phosphorylation	KYMKAIPTIVSDGNT HHHHHCCEECCCCCC	28.09	-
245	Phosphorylation	KAIPTIVSDGNTTFQ HHCCEECCCCCCEEC	35.63	22468782
248	N-linked_Glycosylation	PTIVSDGNTTFQEKC CEECCCCCCEECCCC	40.72	8567640
271	Phosphorylation	HIFRDPLTGDLPWPG EEECCCCCCCCCCCH	33.75	-
335	Phosphorylation	MVMPGMISRILYTEK HHCCCHHHHHHHHCC	12.36	-
437	Phosphorylation	ILVLIGISIAWVPIV HHHHHCHHHHHHHHH	10.88	-
545	Phosphorylation	FITIVVISLLTKPIP HHHHHHHHHHCCCCC	13.01	24719451
562	Phosphorylation	HLYRLCWSLRNSKEE HHHHHHHHHHCCCCC	19.22	24719451
587	Phosphorylation	IQEGPKETIEIETQV CCCCCCCCEEEEECC	30.00	-
606	Phosphorylation	KGIFRRAYDLFCGLE CCHHHHHHHHHHCHH	16.03	-
636	Phosphorylation	KMKMTDTSEKPLWRT HCCCCCCCCCCHHHH	46.57	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC5A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC5A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC5A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAWR_HUMAN	PAWR	physical	15090548

Drug and Disease Associations

• Kegg Disease
• H01261: Congenital glucose-galactose malabsorption (GGM)
• OMIM Disease
• 606824: Congenital glucose/galactose malabsorption (GGM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Membrane topology of the human Na+/glucose cotransporter SGLT1.";
Turk E., Kerner C.J., Lostao M.P., Wright E.M.;
J. Biol. Chem. 271:1925-1934(1996).
Cited for: TOPOLOGY, MUTAGENESIS OF ASN-248, AND GLYCOSYLATION AT ASN-248.
PubMed: 8567640