SBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBP2_MOUSE
• UniProt AC: Q63836
• Protein Name: Selenium-binding protein 2
• Gene Name: Selenbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 472
• Subcellular Localization: Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity)..
• Protein Description: Selenium- and acetaminophen-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)..
• Protein Sequence: MATKCTKCGPGYPTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYSQVIHRLPMPYLKDELHHSGWNTCSSCFGDSTKSRNKLILPGLISSRIYVVDVGSEPRAPKLHKVIEASEIQAKCNVSNTHTSHCLASGEVMVNTLGDLQGNGKGSFVLLDGETFEVKGTWEKPGGASPMGYDFWYQPRHNVMVSTEWAAPNVFKDGFNPAHVEAGLYGSRIFVWDWQRHEIIQTLQMTDGLIPLEIRFLHDPSATQGFVGCALSSNIQRFYKNEEGTWSVEKVIQVPSKKVKGWMLPEMPGLITDILLSLDDRFLYFSNWLHGDIRQYDISNPQKPRLTGQIFLGGSIVRGGSVQVLEDQELTCQPEPLVVKGKRIPGGPQMIQLSLDGKRLYATTSLYSDWDKQFYPDLIREGSVMLQVDVDTVNGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Malonylation	-MATKCTKCGPGYPT -CCCCCCCCCCCCCC	46.82	26320211
7	Ubiquitination	-MATKCTKCGPGYPT -CCCCCCCCCCCCCC	46.82	-
20	Ubiquitination	PTPLEAMKGPREEIV CCCHHHCCCCHHHEE	73.19	22790023
52	Acetylation	ATVDVDPKSPQYSQV EEEECCCCCCCHHHH	71.01	-
52	Malonylation	ATVDVDPKSPQYSQV EEEECCCCCCCHHHH	71.01	26073543
52	Ubiquitination	ATVDVDPKSPQYSQV EEEECCCCCCCHHHH	71.01	-
53	Phosphorylation	TVDVDPKSPQYSQVI EEECCCCCCCHHHHH	23.71	25521595
56	Phosphorylation	VDPKSPQYSQVIHRL CCCCCCCHHHHHHCC	12.40	23984901
57	Phosphorylation	DPKSPQYSQVIHRLP CCCCCCHHHHHHCCC	16.84	23984901
69	Ubiquitination	RLPMPYLKDELHHSG CCCCCHHCCCCCCCC	43.23	22790023
69	Malonylation	RLPMPYLKDELHHSG CCCCCHHCCCCCCCC	43.23	26320211
89	Ubiquitination	SCFGDSTKSRNKLIL HHHCCCCCCCCEECC	51.90	22790023
89	Malonylation	SCFGDSTKSRNKLIL HHHCCCCCCCCEECC	51.90	26320211
93	Ubiquitination	DSTKSRNKLILPGLI CCCCCCCEECCCCCC	35.48	22790023
111	Phosphorylation	IYVVDVGSEPRAPKL EEEEECCCCCCCCCC	44.25	25521595
120	Malonylation	PRAPKLHKVIEASEI CCCCCCHHEEEHHHH	56.17	26320211
120	Ubiquitination	PRAPKLHKVIEASEI CCCCCCHHEEEHHHH	56.17	22790023
125	Phosphorylation	LHKVIEASEIQAKCN CHHEEEHHHHHCCCC	23.57	25521595
162	Phosphorylation	LQGNGKGSFVLLDGE CCCCCCCEEEEECCC	18.70	23567750
179	Acetylation	EVKGTWEKPGGASPM EEEEEEECCCCCCCC	40.29	23954790
179	Malonylation	EVKGTWEKPGGASPM EEEEEEECCCCCCCC	40.29	26320211
179	Ubiquitination	EVKGTWEKPGGASPM EEEEEEECCCCCCCC	40.29	-
201	Phosphorylation	PRHNVMVSTEWAAPN CCCCEEEECCCCCCC	11.52	23984901
202	Phosphorylation	RHNVMVSTEWAAPNV CCCEEEECCCCCCCC	24.92	23984901
211	Ubiquitination	WAAPNVFKDGFNPAH CCCCCCCCCCCCHHH	53.30	22790023
211	Acetylation	WAAPNVFKDGFNPAH CCCCCCCCCCCCHHH	53.30	-
260	Phosphorylation	IRFLHDPSATQGFVG EEECCCCCCCCCCHH	50.43	23984901
262	Phosphorylation	FLHDPSATQGFVGCA ECCCCCCCCCCHHHH	33.30	23984901
279	Ubiquitination	SNIQRFYKNEEGTWS CCHHHHHCCCCCCEE	55.99	-
279	Acetylation	SNIQRFYKNEEGTWS CCHHHHHCCCCCCEE	55.99	22733758
279	Malonylation	SNIQRFYKNEEGTWS CCHHHHHCCCCCCEE	55.99	26320211
284	Phosphorylation	FYKNEEGTWSVEKVI HHCCCCCCEEEEEEE	20.18	22871156
286	Phosphorylation	KNEEGTWSVEKVIQV CCCCCCEEEEEEEEC	21.89	22871156
289	Ubiquitination	EGTWSVEKVIQVPSK CCCEEEEEEEECCCC	42.35	-
289	Malonylation	EGTWSVEKVIQVPSK CCCEEEEEEEECCCC	42.35	26320211
289	Acetylation	EGTWSVEKVIQVPSK CCCEEEEEEEECCCC	42.35	66692673
295	Phosphorylation	EKVIQVPSKKVKGWM EEEEECCCCCCCCCC	46.37	22871156
296	Ubiquitination	KVIQVPSKKVKGWML EEEECCCCCCCCCCC	56.36	22790023
316	Phosphorylation	LITDILLSLDDRFLY CHHHHHHHCCCHHHH	26.72	-
338	Phosphorylation	DIRQYDISNPQKPRL CHHHCCCCCCCCCCC	39.29	29472430
342	Acetylation	YDISNPQKPRLTGQI CCCCCCCCCCCEEEE	33.10	23954790
342	Ubiquitination	YDISNPQKPRLTGQI CCCCCCCCCCCEEEE	33.10	-
342	Malonylation	YDISNPQKPRLTGQI CCCCCCCCCCCEEEE	33.10	26073543
360	Phosphorylation	GSIVRGGSVQVLEDQ CEEECCCCEEEECCC	16.52	22324799
379	Ubiquitination	QPEPLVVKGKRIPGG CCCCEEECCEECCCC	51.76	22790023
397	Acetylation	IQLSLDGKRLYATTS EEEEECCCEEEEEEC	38.61	15605279
397	Malonylation	IQLSLDGKRLYATTS EEEEECCCEEEEEEC	38.61	26073543
397	Ubiquitination	IQLSLDGKRLYATTS EEEEECCCEEEEEEC	38.61	-
411	Succinylation	SLYSDWDKQFYPDLI CCCCCCHHHHHHHHH	37.74	23954790
411	Ubiquitination	SLYSDWDKQFYPDLI CCCCCCHHHHHHHHH	37.74	-
448	Acetylation	NFLVDFGKEPLGPAL CEEEECCCCCCCHHH	57.03	-
448	Malonylation	NFLVDFGKEPLGPAL CEEEECCCCCCCHHH	57.03	26073543
448	Ubiquitination	NFLVDFGKEPLGPAL CEEEECCCCCCCHHH	57.03	-
467	Phosphorylation	RYPGGDCSSDIWI-- CCCCCCCCCCCCC--	35.47	15378723

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBP2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SBP2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of mouse liver using immobilized metalaffinity purification and linear ion trap mass spectrometry.";
Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.;
Rapid Commun. Mass Spectrom. 18:2169-2176(2004).
Cited for: PHOSPHORYLATION AT SER-467.
PubMed: 15378723