SBP2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBP2L_HUMAN
• UniProt AC: Q93073
• Protein Name: Selenocysteine insertion sequence-binding protein 2-like
• Gene Name: SECISBP2L
• Organism: Homo sapiens (Human).
• Sequence Length: 1101
• Protein Description: Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins in vitro..
• Protein Sequence: MDRAPTEQNVKLSAEVEPFIPQKKSPDTFMIPMALPNDNGSVSGVEPTPIPSYLITCYPFVQENQSNRQFPLYNNDIRWQQPNPNPTGPYFAYPIISAQPPVSTEYTYYQLMPAPCAQVMGFYHPFPTPYSNTFQAANTVNAITTECTERPSQLGQVFPLSSHRSRNSNRGSVVPKQQLLQQHIKSKRPLVKNVATQKETNAAGPDSRSKIVLLVDASQQTDFPSDIANKSLSETTATMLWKSKGRRRRASHPTAESSSEQGASEADIDSDSGYCSPKHSNNQPAAGALRNPDSGTMNHVESSMCAGGVNWSNVTCQATQKKPWMEKNQTFSRGGRQTEQRNNSQVGFRCRGHSTSSERRQNLQKRPDNKHLSSSQSHRSDPNSESLYFEDEDGFQELNENGNAKDENIQQKLSSKVLDDLPENSPINIVQTPIPITTSVPKRAKSQKKKALAAALATAQEYSEISMEQKKLQEALSKAAGKKNKTPVQLDLGDMLAALEKQQQAMKARQITNTRPLSYTVVTAASFHTKDSTNRKPLTKSQPCLTSFNSVDIASSKAKKGKEKEIAKLKRPTALKKVILKEREEKKGRLTVDHNLLGSEEPTEMHLDFIDDLPQEIVSQEDTGLSMPSDTSLSPASQNSPYCMTPVSQGSPASSGIGSPMASSTITKIHSKRFREYCNQVLCKEIDECVTLLLQELVSFQERIYQKDPVRAKARRRLVMGLREVTKHMKLNKIKCVIISPNCEKIQSKGGLDEALYNVIAMAREQEIPFVFALGRKALGRCVNKLVPVSVVGIFNYFGAESLFNKLVELTEEARKAYKDMVAAMEQEQAEEALKNVKKVPHHMGHSRNPSAASAISFCSVISEPISEVNEKEYETNWRNMVETSDGLEASENEKEVSCKHSTSEKPSKLPFDTPPIGKQPSLVATGSTTSATSAGKSTASDKEEVKPDDLEWASQQSTETGSLDGSCRDLLNSSITSTTSTLVPGMLEEEEDEDEEEEEDYTHEPISVEVQLNSRIESWVSETQRTMETLQLGKTLNGSEEDNVEQSGEEEAEAPEVLEPGMDSEAWTADQQASPGQQKSSNCSSLNKEHSDSNYTTQTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	TEQNVKLSAEVEPFI CCCCCCCCEEEECCC	19.37	25159151
24	Ubiquitination	EPFIPQKKSPDTFMI ECCCCCCCCCCCEEE	63.07	-
25	Phosphorylation	PFIPQKKSPDTFMIP CCCCCCCCCCCEEEE	34.74	28348404
78	Methylation	PLYNNDIRWQQPNPN CCCCCCCCCCCCCCC	28.19	115387983
185	Ubiquitination	QLLQQHIKSKRPLVK HHHHHHHHHCCCCHH	48.04	-
192	Ubiquitination	KSKRPLVKNVATQKE HHCCCCHHHHHCHHH	54.08	-
198	Ubiquitination	VKNVATQKETNAAGP HHHHHCHHHHHCCCC	63.25	-
200	Phosphorylation	NVATQKETNAAGPDS HHHCHHHHHCCCCCC	36.87	23312004
231	Phosphorylation	PSDIANKSLSETTAT CHHHHCCCCCHHHHH	36.61	29507054
233	Phosphorylation	DIANKSLSETTATML HHHCCCCCHHHHHHH	39.73	27251275
235	Phosphorylation	ANKSLSETTATMLWK HCCCCCHHHHHHHHH	20.53	24114839
242	Ubiquitination	TTATMLWKSKGRRRR HHHHHHHHCCCCCCC	38.03	-
243	Phosphorylation	TATMLWKSKGRRRRA HHHHHHHCCCCCCCC	28.85	-
251	Phosphorylation	KGRRRRASHPTAESS CCCCCCCCCCCCCCC	28.34	23927012
254	Phosphorylation	RRRASHPTAESSSEQ CCCCCCCCCCCCCCC	37.32	23927012
257	Phosphorylation	ASHPTAESSSEQGAS CCCCCCCCCCCCCCC	36.38	30576142
258	Phosphorylation	SHPTAESSSEQGASE CCCCCCCCCCCCCCC	29.42	23927012
259	Phosphorylation	HPTAESSSEQGASEA CCCCCCCCCCCCCCC	43.12	23927012
264	Phosphorylation	SSSEQGASEADIDSD CCCCCCCCCCCCCCC	39.89	30108239
270	Phosphorylation	ASEADIDSDSGYCSP CCCCCCCCCCCCCCC	33.73	25849741
272	Phosphorylation	EADIDSDSGYCSPKH CCCCCCCCCCCCCCC	35.30	30576142
274	Phosphorylation	DIDSDSGYCSPKHSN CCCCCCCCCCCCCCC	8.16	30576142
276	Phosphorylation	DSDSGYCSPKHSNNQ CCCCCCCCCCCCCCC	28.62	30108239
327	Ubiquitination	QKKPWMEKNQTFSRG CCCCHHHHCCCCCCC	37.95	-
333	Methylation	EKNQTFSRGGRQTEQ HHCCCCCCCCCCCCC	47.60	115493615
344 (in isoform 2)	Phosphorylation	-	29.77	27050516
344	Phosphorylation	QTEQRNNSQVGFRCR CCCCCCCCCCCEEEC	29.77	29507054
354	Phosphorylation	GFRCRGHSTSSERRQ CEEECCCCCHHHHHH	32.58	28102081
355	Phosphorylation	FRCRGHSTSSERRQN EEECCCCCHHHHHHH	30.51	28985074
356	Phosphorylation	RCRGHSTSSERRQNL EECCCCCHHHHHHHH	32.96	28102081
357	Phosphorylation	CRGHSTSSERRQNLQ ECCCCCHHHHHHHHH	34.90	28102081
365	Acetylation	ERRQNLQKRPDNKHL HHHHHHHHCCCCCCC	69.89	7480069
370	Ubiquitination	LQKRPDNKHLSSSQS HHHCCCCCCCCCCCC	53.99	-
375	Phosphorylation	DNKHLSSSQSHRSDP CCCCCCCCCCCCCCC	32.12	-
388	Phosphorylation	DPNSESLYFEDEDGF CCCCCCCEEECCCCH	17.75	27642862
415	Phosphorylation	NIQQKLSSKVLDDLP HHHHHHHHHHHHCCC	36.90	27282143
425	Phosphorylation	LDDLPENSPINIVQT HHCCCCCCCCCEEEC	26.04	22199227
437	Phosphorylation	VQTPIPITTSVPKRA EECCCCCCCCCCHHH	13.99	22199227
438	Phosphorylation	QTPIPITTSVPKRAK ECCCCCCCCCCHHHH	28.57	22199227
439	Phosphorylation	TPIPITTSVPKRAKS CCCCCCCCCCHHHHH	27.98	22199227
458	Phosphorylation	ALAAALATAQEYSEI HHHHHHHHHHHHHHC	29.71	28796482
462	Phosphorylation	ALATAQEYSEISMEQ HHHHHHHHHHCCHHH	10.26	28796482
463	Phosphorylation	LATAQEYSEISMEQK HHHHHHHHHCCHHHH	27.92	28796482
466	Phosphorylation	AQEYSEISMEQKKLQ HHHHHHCCHHHHHHH	16.53	28796482
485	Ubiquitination	KAAGKKNKTPVQLDL HHCCCCCCCCEECCH	64.19	-
541	Phosphorylation	NRKPLTKSQPCLTSF CCCCCCCCCCCCCCC	33.83	28348404
550	Phosphorylation	PCLTSFNSVDIASSK CCCCCCCCHHHCCCC	21.11	27251275
573	Phosphorylation	IAKLKRPTALKKVIL HHHHCCCHHHHHHHH	48.97	-
599	Phosphorylation	VDHNLLGSEEPTEMH ECHHCCCCCCCCHHH	38.46	-
648	Phosphorylation	PYCMTPVSQGSPASS CCCCCCCCCCCCCCC	29.99	25332170
664	Phosphorylation	IGSPMASSTITKIHS CCCCCCCCHHHHHHH	17.81	25332170
705	Phosphorylation	VSFQERIYQKDPVRA HHHHHHHHCCCHHHH	18.74	-
726	Phosphorylation	VMGLREVTKHMKLNK HHHHHHHHHHHCCCC	15.52	-
745	Ubiquitination	IISPNCEKIQSKGGL EECCCHHHHHCCCCH	48.52	-
818	Phosphorylation	TEEARKAYKDMVAAM HHHHHHHHHHHHHHH	15.57	19835603
847	Phosphorylation	VPHHMGHSRNPSAAS CCCCCCCCCCHHHHH	28.20	24719451
851	Phosphorylation	MGHSRNPSAASAISF CCCCCCHHHHHHHHH	39.76	28348404
860	Phosphorylation	ASAISFCSVISEPIS HHHHHHHHHHCCCHH	22.07	28348404
863	Phosphorylation	ISFCSVISEPISEVN HHHHHHHCCCHHHCC	34.85	28348404
885	Phosphorylation	WRNMVETSDGLEASE HHHHEECCCCCCCCC	19.04	25627689
891	Phosphorylation	TSDGLEASENEKEVS CCCCCCCCCCCCCCC	31.42	29255136
914	Phosphorylation	PSKLPFDTPPIGKQP CCCCCCCCCCCCCCC	31.20	21815630
922	Phosphorylation	PPIGKQPSLVATGST CCCCCCCCEEEECCC	32.74	28270605
926	Phosphorylation	KQPSLVATGSTTSAT CCCCEEEECCCCCCC	24.96	28270605
928	Phosphorylation	PSLVATGSTTSATSA CCEEEECCCCCCCCC	24.94	28270605
929	Phosphorylation	SLVATGSTTSATSAG CEEEECCCCCCCCCC	26.56	28270605
930	Phosphorylation	LVATGSTTSATSAGK EEEECCCCCCCCCCC	20.33	28270605
931	Phosphorylation	VATGSTTSATSAGKS EEECCCCCCCCCCCC	29.63	28270605
933	Phosphorylation	TGSTTSATSAGKSTA ECCCCCCCCCCCCCC	20.90	28270605
934	Phosphorylation	GSTTSATSAGKSTAS CCCCCCCCCCCCCCC	34.44	28270605
941	Phosphorylation	SAGKSTASDKEEVKP CCCCCCCCCCCCCCC	49.67	24275569
959	Phosphorylation	EWASQQSTETGSLDG HHHHHHCCCCCCCCC	32.98	29449344
961	Phosphorylation	ASQQSTETGSLDGSC HHHHCCCCCCCCCHH	31.96	29449344
963	Phosphorylation	QQSTETGSLDGSCRD HHCCCCCCCCCHHHH	30.61	28985074
967	Phosphorylation	ETGSLDGSCRDLLNS CCCCCCCHHHHHHHC	12.97	29449344
974	Phosphorylation	SCRDLLNSSITSTTS HHHHHHHCCCCCCCC	24.08	18077418
979	Phosphorylation	LNSSITSTTSTLVPG HHCCCCCCCCCCCCC	19.00	18077418
1019	Phosphorylation	QLNSRIESWVSETQR EHHHHHHHHHCHHHH	30.33	18077418
1022	Phosphorylation	SRIESWVSETQRTME HHHHHHHCHHHHHHH	28.77	18077418
1024	Phosphorylation	IESWVSETQRTMETL HHHHHCHHHHHHHHH	18.82	18077418
1048	Phosphorylation	EEDNVEQSGEEEAEA CCCCCCCCCCCHHHC	34.37	28348404
1065	Phosphorylation	VLEPGMDSEAWTADQ CCCCCCCCCCCCCCC	21.96	28348404
1069	Phosphorylation	GMDSEAWTADQQASP CCCCCCCCCCCCCCC	27.66	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBP2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBP2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBP2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL2_HUMAN	DYNLL2	physical	25416956
RMD5A_HUMAN	RMND5A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.