SBNO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBNO2_HUMAN
• UniProt AC: Q9Y2G9
• Protein Name: Protein strawberry notch homolog 2
• Gene Name: SBNO2
• Organism: Homo sapiens (Human).
• Sequence Length: 1366
• Protein Description: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. [PubMed: 18025162 Plays a role as a regulator in the proinflammatory cascade]
• Protein Sequence: MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
227	Ubiquitination	VVETSTLSSVPPPDI EEEECCCCCCCCCCC	29.40	24816145
278	Ubiquitination	RAGFLIGDGAGVGKG CEEEEECCCCCCCCC	36.45	29967540
284	Acetylation	GDGAGVGKGRTVAGV CCCCCCCCCCCCHHH	42.70	7959451
284	Ubiquitination	GDGAGVGKGRTVAGV CCCCCCCCCCCCHHH	42.70	24816145
287	Phosphorylation	AGVGKGRTVAGVILE CCCCCCCCCHHHHHH	24.31	-
307	Phosphorylation	RKKALWFSVSNDLKY CCCEEEEECCCCCCC	17.04	20873877
309	Phosphorylation	KALWFSVSNDLKYDA CEEEEECCCCCCCCH	24.35	20873877
335	Ubiquitination	IAVHALSKIKYGDTT HHHHHHHCCCCCCCC	44.03	29967540
337	Ubiquitination	VHALSKIKYGDTTTS HHHHHCCCCCCCCCC	47.09	-
410	Ubiquitination	AVLDLQNKLPLARVV HHHHHHHHCCCEEHH	38.22	-
457	Ubiquitination	EFLHAIEKRGVGAME HHHHHHHHCCCCCEE	48.62	-
476	Phosphorylation	DMKVSGMYIARQLSF CEECCCEEEEEEEEE	8.58	-
568	Trimethylation	REELARDKCVVIGLQ HHHHHHCCEEEEECC	24.31	-
568	Methylation	REELARDKCVVIGLQ HHHHHHCCEEEEECC	24.31	-
577	Phosphorylation	VVIGLQSTGEARTRE EEEECCCCCCCHHHH	26.53	23403867
582	Phosphorylation	QSTGEARTREVLGEN CCCCCCHHHHHHCCC	37.92	23403867
615	Phosphorylation	IQKHFPSTKRKRDRG HHHHCCCCCCCCCCC	34.80	-
658	Ubiquitination	ISDDSSTESDPGLDS ECCCCCCCCCCCCCC	55.91	29967540
664	Ubiquitination	TESDPGLDSDFNSSP CCCCCCCCCCCCCCH	52.67	29967540
715	Ubiquitination	LERVERLKQDLLDKV HHHHHHHHHHHHHHH	48.24	29967540
721	Ubiquitination	LKQDLLDKVRRLGRE HHHHHHHHHHHHCCC	37.30	29967540
733	Phosphorylation	GRELPVNTLDELIDQ CCCCCCCCHHHHHHH	35.50	22210691
799	Phosphorylation	EKLVAIISEASSSGV CCEEEHHHHHHCCCC	22.46	21406692
802	Phosphorylation	VAIISEASSSGVSLQ EEHHHHHHCCCCCHH	22.45	21406692
803	Phosphorylation	AIISEASSSGVSLQA EHHHHHHCCCCCHHH	37.85	21406692
804	Phosphorylation	IISEASSSGVSLQAD HHHHHHCCCCCHHHH	40.49	21406692
807	Phosphorylation	EASSSGVSLQADRRV HHHCCCCCHHHHHHH	20.49	20068231
837	Ubiquitination	SADRAIQQFGRTHRS CHHHHHHHHCCCCCC	36.33	29967540
844	Phosphorylation	QFGRTHRSNQVSAPE HHCCCCCCCCCCCCC	24.82	25278378
848	Phosphorylation	THRSNQVSAPEYVFL CCCCCCCCCCCCHHH	28.48	25278378
852	Phosphorylation	NQVSAPEYVFLISEL CCCCCCCCHHHHHHH	8.74	24719451
857	Phosphorylation	PEYVFLISELAGERR CCCHHHHHHHHCCHH	28.80	24719451
871	Acetylation	RFASIVAKRLESLGA HHHHHHHHHHHHCCC	46.77	25953088
871	Ubiquitination	RFASIVAKRLESLGA HHHHHHHHHHHHCCC	46.77	-
875	Phosphorylation	IVAKRLESLGALTHG HHHHHHHHCCCCCCC	36.37	-
894	Ubiquitination	TESRDLSKYNFENKY CCCCCHHHHCCCCCC	52.06	29967540
900	Ubiquitination	SKYNFENKYGTRALH HHHCCCCCCHHHHHH	37.55	-
939	Ubiquitination	PTFFRDMKQGLLSVG CCHHHHHHCCCCCCC	45.57	-
939	Sumoylation	PTFFRDMKQGLLSVG CCHHHHHHCCCCCCC	45.57	-
939	Sumoylation	PTFFRDMKQGLLSVG CCHHHHHHCCCCCCC	45.57	-
961	Ubiquitination	NGCLDVEKDCSITKF CCCCCCCCCCHHHHH	64.98	-
967	Ubiquitination	EKDCSITKFLNRILG CCCCHHHHHHHHHHC	46.30	-
992	Ubiquitination	QYFSDTFDHLIEMDK HHHHHHHHHHHHHHH	37.46	29967540
1049	Ubiquitination	ISVDRGLKWEDAFAK EEECCCCCHHHHHHH	51.89	29967540
1064	Phosphorylation	SLALTGPYDGFYLSY HHHHHCCCCCEEEEE	30.00	25884760
1068	Phosphorylation	TGPYDGFYLSYKVRG HCCCCCEEEEEEEEC	10.56	25884760
1071	Phosphorylation	YDGFYLSYKVRGNKP CCCEEEEEEEECCCC	15.77	25884760
1072	Sumoylation	DGFYLSYKVRGNKPS CCEEEEEEEECCCCC	23.29	-
1072	Sumoylation	DGFYLSYKVRGNKPS CCEEEEEEEECCCCC	23.29	-
1095	Ubiquitination	GQFFTVYKPNIGRQS CCEEEEECCCCCCHH	27.53	-
1153	Ubiquitination	CRLAQEGKDCLQGLR HHHHHHCCHHHHHHH	44.51	-
1165	Phosphorylation	GLRLRHHYMLCGALL HHHHHHHHHHHHHHH	5.90	-
1172	Ubiquitination	YMLCGALLRVWGRIA HHHHHHHHHHHHHHH	4.04	29967540
1189	Phosphorylation	MADVSSSSYLQIVRL HCCCCCCHHEEEEEE	31.63	-
1198	Phosphorylation	LQIVRLKTKDRKKQV EEEEEEECCCCCHHC	42.65	-
1229	Ubiquitination	RLMDADVKRRQAPAL HCCCCCCCCCCCCHH	42.27	29967540
1229	Acetylation	RLMDADVKRRQAPAL HCCCCCCCCCCCCHH	42.27	25953088
1329	Phosphorylation	SLHAGPPSEGALGEG HHHCCCCCCCCCCCC	52.36	28555341
1356	Phosphorylation	RQSVIQFSPPFPGAQ CCCEEECCCCCCCCC	18.45	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBNO2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBNO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBNO2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SBNO2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.