dbPTM

SASH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SASH1_MOUSE
UniProt AC	P59808
Protein Name	SAM and SH3 domain-containing protein 1
Gene Name	Sash1
Organism	Mus musculus (Mouse).
Sequence Length	1230
Subcellular Localization
Protein Description	May have a role in a signaling pathway. Could act as a tumor suppressor..
Protein Sequence	MEEDAGAASPAPEPEPEVDPARELEPEAGVSESISRLWTDVMGILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPDASPTSLQLRSQIEESLGFCSAVSTPEVERKYPLHKSNSEDGCVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSSTLDPADWPDGSYPTLDGSSTCNSREQSDDETEDSVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSAEGGEEHVFENSPVQDERSALYSGVHKKPFFYDGSPEKPPEDDADSLTPSPSSSSLDTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLSHGRTCSFGGFDLTNRSLHVGSNNSDPAGKEGDFVYKEVIKSPPAPRISLGKKVRSVKETMRKRMSKKYSSPVSEQDSGLDGMPSSPASGKPDSEHVDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRPTRRRKKGRPSQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSNSDQSGSQEKLLVDNQGLSGRSPRDSGCYESSENLENAKTHKPSVLSTKSSTESNLKSFTRSQPGNYPTLPLMKSGEVRKQGEEGRLGRGLAPDTAKSCDVPSVTDLSKNRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKNVPTEMPETCSQNVPEVPQKTSACTSKALPRGRDPTADVMLLTQSKRFSDPPKTMAKKLDGSVVASNLGIAPPQCIPRDFEAQPPVKPGLTRTSLEGLRKGHDHHPLGTKEGVDGEQSAPETRTQSRHPSQPPPVPAKKSRERLANGLHLVPSPEAPILPLKKASPASPVSPSDCPSPREPRPSSGTEPGSPACTRPPPWLAELPESTSLQEHGVKLGPVLSRKVSCVRGVDLEMLTENKLQAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLEQPERDVATNMDQIRVKLLRKQHRMAIPSGGLTEICRKPLSPGCVASMSDWLISIGLPMYTSTLSDAGFSTLSQVPSLSHSCLQEAGITEERHIRKLITAARLFKLPPSPEAM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	EEDAGAASPAPEPEP CCCCCCCCCCCCCCC	22.51	30635358
83	Phosphorylation	ELRKRRVSQDLDVEK HHHHHHHHCCCCCCC	19.03	26824392
94	Phosphorylation	DVEKPDASPTSLQLR CCCCCCCCCCHHHHH	35.77	28725479
96	Phosphorylation	EKPDASPTSLQLRSQ CCCCCCCCHHHHHHH	39.30	21082442
97	Phosphorylation	KPDASPTSLQLRSQI CCCCCCCHHHHHHHH	19.94	25619855
112	Phosphorylation	EESLGFCSAVSTPEV HHHHCCCCCCCCHHH	29.46	30635358
115	Phosphorylation	LGFCSAVSTPEVERK HCCCCCCCCHHHHHH	37.65	30635358
116	Phosphorylation	GFCSAVSTPEVERKY CCCCCCCCHHHHHHC	19.50	30635358
128	Phosphorylation	RKYPLHKSNSEDGCV HHCCCCCCCCCCCCC	34.54	27087446
130	Phosphorylation	YPLHKSNSEDGCVGK CCCCCCCCCCCCCCC	44.12	25521595
162	Phosphorylation	QKGIMRQTSKGEDVG CCCCCCCCCCCCCHH	23.26	29899451
163	Phosphorylation	KGIMRQTSKGEDVGY CCCCCCCCCCCCHHH	30.26	27087446
170	Phosphorylation	SKGEDVGYVASEITM CCCCCHHHEEEEECC	7.84	20531401
225	Phosphorylation	PADWPDGSYPTLDGS CCCCCCCCCCCCCCC	35.01	30635358
226	Phosphorylation	ADWPDGSYPTLDGSS CCCCCCCCCCCCCCC	13.03	30635358
228	Phosphorylation	WPDGSYPTLDGSSTC CCCCCCCCCCCCCCC	29.28	30635358
232	Phosphorylation	SYPTLDGSSTCNSRE CCCCCCCCCCCCCCC	23.34	30635358
233	Phosphorylation	YPTLDGSSTCNSREQ CCCCCCCCCCCCCCC	42.37	30635358
234	Phosphorylation	PTLDGSSTCNSREQS CCCCCCCCCCCCCCC	19.87	30635358
237	Phosphorylation	DGSSTCNSREQSDDE CCCCCCCCCCCCCCC	39.06	30635358
241	Phosphorylation	TCNSREQSDDETEDS CCCCCCCCCCCCHHH	42.13	25521595
245	Phosphorylation	REQSDDETEDSVKFK CCCCCCCCHHHHHHH	52.68	27742792
248	Phosphorylation	SDDETEDSVKFKRLH CCCCCHHHHHHHHHH	22.45	30635358
260	Phosphorylation	RLHKLVNSTRRVRKK HHHHHHHHHHHHHHH	18.80	27149854
300	Phosphorylation	QDERSALYSGVHKKP CCHHHHHHCCCCCCC	11.77	25367039
301	Phosphorylation	DERSALYSGVHKKPF CHHHHHHCCCCCCCC	34.88	30635358
313	Phosphorylation	KPFFYDGSPEKPPED CCCCCCCCCCCCCCC	27.30	25338131
326	Phosphorylation	EDDADSLTPSPSSSS CCCCCCCCCCCCCCC	26.18	25338131
328	Phosphorylation	DADSLTPSPSSSSLD CCCCCCCCCCCCCCC	31.98	25338131
330	Phosphorylation	DSLTPSPSSSSLDTW CCCCCCCCCCCCCCC	47.38	25338131
348	Phosphorylation	RKLVKTFSKGESRGL HHHHHHCCCCCCCCC	45.01	29514104
364	Phosphorylation	KPPKKMGTFFSYPEE CCCHHCCCCCCCCHH	20.29	29472430
367	Phosphorylation	KKMGTFFSYPEEEKA HHCCCCCCCCHHHHH	35.27	29472430
368	Phosphorylation	KMGTFFSYPEEEKAQ HCCCCCCCCHHHHHH	14.98	29472430
378	Phosphorylation	EEKAQKVSRSLTEGE HHHHHHHHHHCCCCH	24.16	25338131
380	Phosphorylation	KAQKVSRSLTEGEMK HHHHHHHHCCCCHHH	31.94	25521595
382	Phosphorylation	QKVSRSLTEGEMKKG HHHHHHCCCCHHHCC	43.10	22817900
392	Phosphorylation	EMKKGLGSLSHGRTC HHHCCCCCCCCCCCC	31.57	26824392
398	Phosphorylation	GSLSHGRTCSFGGFD CCCCCCCCCCCCCEE	19.66	27087446
400	Phosphorylation	LSHGRTCSFGGFDLT CCCCCCCCCCCEECC	26.72	25521595
407	Phosphorylation	SFGGFDLTNRSLHVG CCCCEECCCCEEEEC	30.36	25777480
435	Phosphorylation	VYKEVIKSPPAPRIS EEEHHHCCCCCCCCC	25.62	26824392
445	Ubiquitination	APRISLGKKVRSVKE CCCCCCCHHHHHHHH	54.08	-
462	Phosphorylation	RKRMSKKYSSPVSEQ HHHHHHHCCCCCCCC	20.37	25338131
463	Phosphorylation	KRMSKKYSSPVSEQD HHHHHHCCCCCCCCC	36.73	25338131
464	Phosphorylation	RMSKKYSSPVSEQDS HHHHHCCCCCCCCCC	26.65	25338131
471	Phosphorylation	SPVSEQDSGLDGMPS CCCCCCCCCCCCCCC	40.73	29550500
478	Phosphorylation	SGLDGMPSSPASGKP CCCCCCCCCCCCCCC	39.81	29550500
479	Phosphorylation	GLDGMPSSPASGKPD CCCCCCCCCCCCCCC	20.72	29550500
482	Phosphorylation	GMPSSPASGKPDSEH CCCCCCCCCCCCHHC	51.22	29550500
487	Phosphorylation	PASGKPDSEHVDKPK CCCCCCCHHCCCCCC	37.82	29550500
500	Phosphorylation	PKLKAGGSVESLRSS CCCCCCCCHHHHHHH	23.07	23527152
503	Phosphorylation	KAGGSVESLRSSLSG CCCCCHHHHHHHHCC	27.25	21082442
512	Phosphorylation	RSSLSGQSSMSGQTV HHHHCCCCCCCCCEE	31.37	25338131
531	Phosphorylation	SSTSNRESVKSEDGD CCCCCCCCCCCCCCC	31.44	29550500
534	Phosphorylation	SNRESVKSEDGDDEE CCCCCCCCCCCCCCC	38.47	23684622
556	Phosphorylation	CGRARVHTDFTPSPY CCCEEEECCCCCCCC	29.92	30635358
559	Phosphorylation	ARVHTDFTPSPYDTD EEEECCCCCCCCCCC	26.18	30635358
561	Phosphorylation	VHTDFTPSPYDTDSL EECCCCCCCCCCCCC	32.79	30635358
563	Phosphorylation	TDFTPSPYDTDSLKL CCCCCCCCCCCCCEE	35.49	22345495
565	Phosphorylation	FTPSPYDTDSLKLKK CCCCCCCCCCCEECC	22.96	30635358
567	Phosphorylation	PSPYDTDSLKLKKGD CCCCCCCCCEECCCC	29.51	25367039
630	Phosphorylation	GRPSQPKSVEDLLDR CCCCCCCCHHHHHHH	37.11	27180971
690	Phosphorylation	AVELLQEYDSNSDQS HHHHHHHHCCCCCCC	16.23	29550500
692	Phosphorylation	ELLQEYDSNSDQSGS HHHHHHCCCCCCCCC	37.01	30352176
694	Phosphorylation	LQEYDSNSDQSGSQE HHHHCCCCCCCCCCE	40.76	20531401
697	Phosphorylation	YDSNSDQSGSQEKLL HCCCCCCCCCCEEEE	45.46	29550500
699	Phosphorylation	SNSDQSGSQEKLLVD CCCCCCCCCEEEEEC	40.17	30352176
711	Phosphorylation	LVDNQGLSGRSPRDS EECCCCCCCCCCCCC	38.70	26824392
714	Phosphorylation	NQGLSGRSPRDSGCY CCCCCCCCCCCCCCC	28.01	25521595
718	Phosphorylation	SGRSPRDSGCYESSE CCCCCCCCCCCCCCC	31.85	30635358
721	Phosphorylation	SPRDSGCYESSENLE CCCCCCCCCCCCHHH	23.52	25619855
723	Phosphorylation	RDSGCYESSENLENA CCCCCCCCCCHHHHH	19.24	25521595
724	Phosphorylation	DSGCYESSENLENAK CCCCCCCCCHHHHHC	20.68	25521595
743	Phosphorylation	SVLSTKSSTESNLKS CHHHCCCCCCHHHHH	37.44	25338131
744	Phosphorylation	VLSTKSSTESNLKSF HHHCCCCCCHHHHHH	50.99	28576409
759	Phosphorylation	TRSQPGNYPTLPLMK HCCCCCCCCCCCCCC	11.96	22817900
805	Phosphorylation	DLSKNRRSLPVSICR CCCCCCCCCCHHHHC	33.51	26824392
809	Phosphorylation	NRRSLPVSICRSCET CCCCCCHHHHCCCCC	17.65	25521595
813	Phosphorylation	LPVSICRSCETLEGP CCHHHHCCCCCCCCC	16.34	25521595
816	Phosphorylation	SICRSCETLEGPEPV HHHCCCCCCCCCCCC	34.14	25521595
829	Phosphorylation	PVESWPRSHSLDDLQ CCCCCCCCCCHHHHC	17.22	25521595
831	Phosphorylation	ESWPRSHSLDDLQGD CCCCCCCCHHHHCCC	34.44	24925903
847	Phosphorylation	DVGKNVPTEMPETCS CCCCCCCCCCCCHHH	40.40	21183079
892	Phosphorylation	LTQSKRFSDPPKTMA HCCCCCCCCCCCHHH	53.92	27180971
909	Phosphorylation	LDGSVVASNLGIAPP CCCCEEECCCCCCCC	22.45	26824392
934	Phosphorylation	PPVKPGLTRTSLEGL CCCCCCCCCCCHHHH	37.50	25338131
996	Phosphorylation	NGLHLVPSPEAPILP CCCCCCCCCCCCCCC	28.08	27180971
1008	Phosphorylation	ILPLKKASPASPVSP CCCCCCCCCCCCCCH	29.85	25619855
1011	Phosphorylation	LKKASPASPVSPSDC CCCCCCCCCCCHHHC	29.26	25521595
1014	Phosphorylation	ASPASPVSPSDCPSP CCCCCCCCHHHCCCC	23.28	25521595
1016	Phosphorylation	PASPVSPSDCPSPRE CCCCCCHHHCCCCCC	44.32	23684622
1020	Phosphorylation	VSPSDCPSPREPRPS CCHHHCCCCCCCCCC	42.81	25619855
1027	Phosphorylation	SPREPRPSSGTEPGS CCCCCCCCCCCCCCC	42.55	26060331
1028	Phosphorylation	PREPRPSSGTEPGSP CCCCCCCCCCCCCCC	53.03	26060331
1034	Phosphorylation	SSGTEPGSPACTRPP CCCCCCCCCCCCCCC	21.75	29899451
1038	Phosphorylation	EPGSPACTRPPPWLA CCCCCCCCCCCCCHH	48.60	26060331
1065	Phosphorylation	VKLGPVLSRKVSCVR CCHHHHHHCCCHHHC	30.23	25338131
1069	Phosphorylation	PVLSRKVSCVRGVDL HHHHCCCHHHCCCCH	15.21	23608596
1080	Phosphorylation	GVDLEMLTENKLQAE CCCHHHHCCCCCCCC	35.88	27180971

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SASH1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SASH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SASH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SASH1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SASH1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-813 AND SER-831, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, AND MASSSPECTROMETRY.	17203969 [Abstract]
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations."; Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.; Mol. Cell. Proteomics 5:914-922(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-831, AND MASSSPECTROMETRY.	16452087 [Abstract]