SARM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SARM1_MOUSE
• UniProt AC: Q6PDS3
• Protein Name: Sterile alpha and TIR motif-containing protein 1
• Gene Name: Sarm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 724
• Subcellular Localization: Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Associated with microtubules.
• Protein Description: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. Can restrict West Nile virus (WNV) pathogenesis..
• Protein Sequence: MVLTLLFSAYKLCRFFTMSGPRPGADRLTVPGPDRSGGASPWWAAGGRGSREVSPGVGTEVQGALERSLPELQQALSELKQASAARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSALAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFREQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKLSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVIAARNFVLVLSAGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQALPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRPSQDSSAGSDTSLEGATPMGLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MVLTLLFSAYKLCRF CHHHHHHHHHHHHHH	30.56	30482847
19	Phosphorylation	LCRFFTMSGPRPGAD HHHHHHCCCCCCCCC	42.46	28059163
29 (in isoform 3)	Phosphorylation	-	26.08	24719451
29	Phosphorylation	RPGADRLTVPGPDRS CCCCCCEEECCCCCC	26.08	-
40	Phosphorylation	PDRSGGASPWWAAGG CCCCCCCCCCHHCCC	25.07	28066266
54	Phosphorylation	GRGSREVSPGVGTEV CCCCCCCCCCCCHHH	15.93	25521595
183	Phosphorylation	EPVELARSVAGILEH CHHHHHHHHHHHHHH	15.65	-
363 (in isoform 3)	Ubiquitination	-	44.78	22790023
363	Ubiquitination	KSLQGKTKVFSDIGA HHHCCCCCCCCCHHH	44.78	22790023
387	Phosphorylation	YSTNGTTSALAKRAL CCCCCHHHHHHHHHH	22.56	21454597
453	Phosphorylation	LTDEELQTDLGMKSS CCHHHHHHHHCCCCH	45.90	26824392
548	Phosphorylation	AAREMLHSPLPCTGG HHHHHHCCCCCCCCC	24.95	25521595
549 (in isoform 3)	Phosphorylation	-	29.58	22942356
553	Phosphorylation	LHSPLPCTGGKLSGD HCCCCCCCCCCCCCC	47.21	24925903
558	Phosphorylation	PCTGGKLSGDTPDVF CCCCCCCCCCCCCEE	37.80	22817900
561	Phosphorylation	GGKLSGDTPDVFISY CCCCCCCCCCEEEEE	25.55	22807455
572	Phosphorylation	FISYRRNSGSQLASL EEEEECCCHHHHHHH	37.70	25521595
574	Phosphorylation	SYRRNSGSQLASLLK EEECCCHHHHHHHHH	23.11	29899451
578	Phosphorylation	NSGSQLASLLKVHLQ CCHHHHHHHHHHHHH	42.71	20415495
711	Phosphorylation	SQDSSAGSDTSLEGA CCCCCCCCCCCCCCC	37.11	29899451
713	Phosphorylation	DSSAGSDTSLEGATP CCCCCCCCCCCCCCC	36.59	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SARM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
548	S	Oxidation	Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration.	21183079
548	S	Phosphorylation	Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration.	21183079
548	S	Phosphorylation	Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD(+) hydrolase (NADase) activity.	21183079

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SARM1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SARM1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.