SAPC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAPC2_HUMAN
• UniProt AC: Q86UD0
• Protein Name: Suppressor APC domain-containing protein 2 {ECO:0000305}
• Gene Name: SAPCD2 {ECO:0000312|HGNC:HGNC:28055}
• Organism: Homo sapiens (Human).
• Sequence Length: 394
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cell cortex . Apical cell membrane . Cell junction, tight junction . Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region
• Protein Description: Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. [PubMed: 26766442 Involved also in positive regulation of cell proliferation and tumor cell growth]
• Protein Sequence: MAGAAMAERGRVPPPAPAPSTEGLPRAFLQSLRTLFDILDDRRRGCVHLREIESRWQGTDARELPRGVLEGLRQVAPASGYLTFERFVAGLRTSLLSADGGPRDPTRAPARPGDQPPPPPQRLVFAPADEPRTVLERKPLPLGVRAPLAGPSAAARSPEQLCAPAEAAPCPAEPERSQSAALEPSSSADAGAVACRALEADSGDARRAPRARGERRRHTIASGVDCGLLKQMKELEQEKEVLLQGLEMMARGRDWYQQQLQRVQERQRRLGQSRASADFGAAGSPRPLGRLLPKVQEVARCLGELLAAACASRALPPSSSGPPCPALTSTSPPVWQQQTILMLKEQNRLLTQEVTEKSERITQLEQEKSALIKQLFEARALSQQDGGPLDSTFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	LRQVAPASGYLTFER HHHHCCCCCEEEHHH	27.23	28152594
81	Phosphorylation	QVAPASGYLTFERFV HHCCCCCEEEHHHHH	10.48	25884760
83	Phosphorylation	APASGYLTFERFVAG CCCCCEEEHHHHHHH	18.24	28152594
152	Phosphorylation	RAPLAGPSAAARSPE CCCCCCCCHHHCCHH	29.62	24719451
157	Phosphorylation	GPSAAARSPEQLCAP CCCHHHCCHHHHCCC	28.23	25159151
179	Phosphorylation	AEPERSQSAALEPSS CCCCHHHCCCCCCCC	19.43	28348404
219	Phosphorylation	RGERRRHTIASGVDC HCHHHHHHHHHCCCH	19.21	22617229
222	Phosphorylation	RRRHTIASGVDCGLL HHHHHHHHCCCHHHH	35.18	30576142
230	Ubiquitination	GVDCGLLKQMKELEQ CCCHHHHHHHHHHHH	54.08	32015554
256	Phosphorylation	MARGRDWYQQQLQRV HHHCHHHHHHHHHHH	10.75	27174698
273	Phosphorylation	RQRRLGQSRASADFG HHHHHHCHHHHHCCC	28.19	28102081
276	Phosphorylation	RLGQSRASADFGAAG HHHCHHHHHCCCCCC	27.53	29496963
284	Phosphorylation	ADFGAAGSPRPLGRL HCCCCCCCCCCHHHH	17.01	25159151
328	Phosphorylation	GPPCPALTSTSPPVW CCCCCCCCCCCCCHH	31.87	28348404
329	Phosphorylation	PPCPALTSTSPPVWQ CCCCCCCCCCCCHHH	27.95	28348404
330	Phosphorylation	PCPALTSTSPPVWQQ CCCCCCCCCCCHHHH	39.76	28348404
331	Phosphorylation	CPALTSTSPPVWQQQ CCCCCCCCCCHHHHH	27.29	28348404
362	Phosphorylation	TEKSERITQLEQEKS HHHHHHHHHHHHHHH	33.07	28842319
369	Phosphorylation	TQLEQEKSALIKQLF HHHHHHHHHHHHHHH	27.79	28842319

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAPC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAPC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAPC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SAPC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.