SAP30_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAP30_DROME
• UniProt AC: Q9VXB3
• Protein Name: Histone deacetylase complex subunit SAP30 homolog
• Gene Name: Sap30
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 173
• Subcellular Localization: Nucleus.
• Protein Description: Component of the class 1 Sin3A-histone deacetylase (Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle..
• Protein Sequence: MNNGFSTGEEDSRGHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSSDPAAQHIYICDHHKERIQSVRTKRRRKDSEDDSNETDTDLHEFPDLYQLGVSTLRRYKRHFKVQTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKNGLGNDTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNNGFSTGEEDSR --CCCCCCCCCCCCC	36.58	19429919
7	Phosphorylation	-MNNGFSTGEEDSRG -CCCCCCCCCCCCCC	46.48	19429919
84	Phosphorylation	TKRRRKDSEDDSNET HHHHCCCCCCCCCCC	46.06	19429919
88	Phosphorylation	RKDSEDDSNETDTDL CCCCCCCCCCCCCCH	49.22	23607784
91	Phosphorylation	SEDDSNETDTDLHEF CCCCCCCCCCCHHHC	48.74	23607784
93	Phosphorylation	DDSNETDTDLHEFPD CCCCCCCCCHHHCHH	48.13	23607784
102	Phosphorylation	LHEFPDLYQLGVSTL HHHCHHHHHHHHHHH	14.74	23607784
108	Phosphorylation	LYQLGVSTLRRYKRH HHHHHHHHHHHHHHH	23.13	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAP30_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAP30_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAP30_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-88; THR-91 ANDTHR-93, AND MASS SPECTROMETRY.
PubMed: 18327897