SAMD8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAMD8_MOUSE
• UniProt AC: Q9DA37
• Protein Name: Sphingomyelin synthase-related protein 1
• Gene Name: Samd8
• Organism: Mus musculus (Mouse).
• Sequence Length: 478
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway (By similarity)..
• Protein Sequence: MPAGSRAGSRLRSGSLPRPSRLTLKALRPAYAPRTPDSNGDLDTGSELGPGSPAPTAEEVEKEMAGPSQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHTDVLEEMGYNSDSPMSPMTPFLSALQSADWLCNGEPTHSCDGPIPDLSSDQYQYMNGKNKHSARRLDPEYWKTILSCVYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFSMTEVCGVILCYIWILVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLRRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RAGSRLRSGSLPRPS CCCCCCCCCCCCCCC	37.01	23984901
15	Phosphorylation	GSRLRSGSLPRPSRL CCCCCCCCCCCCCCC	36.13	23984901
20	Phosphorylation	SGSLPRPSRLTLKAL CCCCCCCCCCCHHHH	41.00	23984901
52	Phosphorylation	GSELGPGSPAPTAEE CCCCCCCCCCCCHHH	22.48	29514104
129	Ubiquitination	IKVLGDIKRLMLSVR EEEHHHHHHHHHHHH	44.19	-
256	Phosphorylation	LPDIFLDSVPRIPWA CCCCCCCCCCCCCCC	35.85	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAMD8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAMD8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAMD8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SAMD8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.