SAM9L_HUMAN - dbPTM
SAM9L_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAM9L_HUMAN
UniProt AC Q8IVG5
Protein Name Sterile alpha motif domain-containing protein 9-like
Gene Name SAMD9L
Organism Homo sapiens (Human).
Sequence Length 1584
Subcellular Localization Early endosome .
Protein Description May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors..
Protein Sequence MSKQVSLPEMIKDWTKEHVKKWVNEDLKINEQYGQILLSEEVTGLVLQELTEKDLVEMGLPWGPALLIKRSYNKLNSKSPESDNHDPGQLDNSKPSKTEHQKNPKHTKKEEENSMSSNIDYDPREIRDIKQEESILMKENVLDEVANAKHKKKGKLKPEQLTCMPYPFDQFHDSHRYIEHYTLQPETGALNLIDPIHEFKALTNTETATEVDIKMKFSNEVFRFASACMNSRTNGTIHFGVKDKPHGEIVGVKITSKAAFIDHFNVMIKKYFEESEINEAKKCIREPRFVEVLLQNNTPSDRFVIEVDTIPKHSICNDKYFYIQMQICKDKIWKQNQNLSLFVREGASSRDILANSKQRDVDFKAFLQNLKSLVASRKEAEEEYGMKAMKKESEGLKLVKLLIGNRDSLDNSYYDWYILVTNKCHPNQIKHLDFLKEIKWFAVLEFDPESMINGVVKAYKESRVANLHFPNQYEDKTTNMWEKISTLNLYQQPSWIFCNGRSDLKSETYKPLEPHLWQRERASEVRKLILFLTDENIMTRGKFLVVFLLLSSVESPGDPLIETFWAFYQALKGMENMLCISVNSHIYQRWKDLLQTRMKMEDELTNHSISTLNIELVNSTILKLKSVTRSSRRFLPARGSSSVILEKKKEDVLTALEILCENECTETDIEKDKSKFLEFKKSKEEHFYRGGKVSWWNFYFSSENYSSDFVKRDSYEKLKDLIHCWAESPKPIFAKIINLYHHPGCGGTTLAMHVLWDLKKNFRCAVLKNKTTDFAEIAEQVINLVTYRAKSHQDYIPVLLLVDDFEEQENVYFLQNAIHSVLAEKDLRYEKTLVIILNCMRSRNPDESAKLADSIALNYQLSSKEQRAFGAKLKEIEKQHKNCENFYSFMIMKSNFDETYIENVVRNILKGQDVDSKEAQLISFLALLSSYVTDSTISVSQCEIFLGIIYTSTPWEPESLEDKMGTYSTLLIKTEVAEYGRYTGVRIIHPLIALYCLKELERSYHLDKCQIALNILEENLFYDSGIGRDKFQHDVQTLLLTRQRKVYGDETDTLFSPLMEALQNKDIEKVLSAGSRRFPQNAFICQALARHFYIKEKDFNTALDWARQAKMKAPKNSYISDTLGQVYKSEIKWWLDGNKNCRSITVNDLTHLLEAAEKASRAFKESQRQTDSKNYETENWSPQKSQRRYDMYNTACFLGEIEVGLYTIQILQLTPFFHKENELSKKHMVQFLSGKWTIPPDPRNECYLALSKFTSHLKNLQSDLKRCFDFFIDYMVLLKMRYTQKEIAEIMLSKKVSRCFRKYTELFCHLDPCLLQSKESQLLQEENCRKKLEALRADRFAGLLEYLNPNYKDATTMESIVNEYAFLLQQNSKKPMTNEKQNSILANIILSCLKPNSKLIQPLTTLKKQLREVLQFVGLSHQYPGPYFLACLLFWPENQELDQDSKLIEKYVSSLNRSFRGQYKRMCRSKQASTLFYLGKRKGLNSIVHKAKIEQYFDKAQNTNSLWHSGDVWKKNEVKDLLRRLTGQAEGKLISVEYGTEEKIKIPVISVYSGPLRSGRNIERVSFYLGFSIEGPLAYDIEVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationYNKLNSKSPESDNHD
HHHHCCCCCCCCCCC		33.4525159151
134PhosphorylationRDIKQEESILMKENV
HHHHHHHHHHHHHCH		21.9223403867
216UbiquitinationTEVDIKMKFSNEVFR
CEEEEEEECCHHHHH		40.41-
226PhosphorylationNEVFRFASACMNSRT
HHHHHHHHHHHCCCC		21.2020068231
231PhosphorylationFASACMNSRTNGTIH
HHHHHHCCCCCCEEE		17.3820068231
233PhosphorylationSACMNSRTNGTIHFG
HHHHCCCCCCEEEEE		37.5120068231
236PhosphorylationMNSRTNGTIHFGVKD
HCCCCCCEEEEEECC		17.2220068231
275PhosphorylationIKKYFEESEINEAKK
HHHHHHHHCHHHHHH		36.2629759185
320PhosphorylationHSICNDKYFYIQMQI
CCCCCCCEEEEEEEH		12.41-
348PhosphorylationLFVREGASSRDILAN
EEEECCCCHHHHHHC		36.44-
349PhosphorylationFVREGASSRDILANS
EEECCCCHHHHHHCC		33.1822210691
356PhosphorylationSRDILANSKQRDVDF
HHHHHHCCCCCCCCH		25.2622210691
357UbiquitinationRDILANSKQRDVDFK
HHHHHCCCCCCCCHH		49.5129967540
372PhosphorylationAFLQNLKSLVASRKE
HHHHHHHHHHHCHHH		31.1029116813
384PhosphorylationRKEAEEEYGMKAMKK
HHHHHHHHHHHHHHH		26.2929116813
408PhosphorylationLLIGNRDSLDNSYYD
HHHCCCCCCCCCCCC		34.0924719451
417PhosphorylationDNSYYDWYILVTNKC
CCCCCCEEEEEECCC		4.9724719451
421PhosphorylationYDWYILVTNKCHPNQ
CCEEEEEECCCCHHH		26.0524719451
436MethylationIKHLDFLKEIKWFAV
CCCHHHHHHCCEEEE		58.34-
436UbiquitinationIKHLDFLKEIKWFAV
CCCHHHHHHCCEEEE		58.34-
714PhosphorylationSDFVKRDSYEKLKDL
CCCCCHHCHHHHHHH		38.9425690035
715PhosphorylationDFVKRDSYEKLKDLI
CCCCHHCHHHHHHHH		22.7525690035
735UbiquitinationSPKPIFAKIINLYHH
CCCCHHHHHHHHHCC		33.11-
842PhosphorylationIILNCMRSRNPDESA
HHHHHHHCCCCCHHH		14.99-
995PhosphorylationIHPLIALYCLKELER
HHHHHHHHHHHHHHH		6.16-
1047PhosphorylationLTRQRKVYGDETDTL
HHCCCHHHCCCCCCC		23.15-
1065UbiquitinationLMEALQNKDIEKVLS
HHHHHCCCCHHHHHC		47.3129967540
1097UbiquitinationRHFYIKEKDFNTALD
HHHEECCCCHHHHHH		63.7229967540
1118PhosphorylationMKAPKNSYISDTLGQ
CCCCCCCCCCCCCCH		17.53-
1177PhosphorylationTDSKNYETENWSPQK
HCCCCCCCCCCCCCC		25.0230108239
1181PhosphorylationNYETENWSPQKSQRR
CCCCCCCCCCCHHHH		29.0930108239
1224PhosphorylationFHKENELSKKHMVQF
CCCCCCCCHHHHHHH		33.2222210691
1282PhosphorylationMVLLKMRYTQKEIAE
HHHHHCCCCHHHHHH		15.2727251275
1283PhosphorylationVLLKMRYTQKEIAEI
HHHHCCCCHHHHHHH		23.8524719451
1293PhosphorylationEIAEIMLSKKVSRCF
HHHHHHHHHHHHHHH		17.0422817900
1404PhosphorylationSKLIQPLTTLKKQLR
CCCCHHHHHHHHHHH		36.4429083192
1405PhosphorylationKLIQPLTTLKKQLRE
CCCHHHHHHHHHHHH		44.2429083192
1458PhosphorylationYVSSLNRSFRGQYKR
HHHHCCHHHHHHHHH		20.4424719451
1526PhosphorylationKDLLRRLTGQAEGKL
HHHHHHHHCCCCCCE		25.99-
1535O-linked_GlycosylationQAEGKLISVEYGTEE
CCCCCEEEEEECCCC		21.2330379171
1543UbiquitinationVEYGTEEKIKIPVIS
EEECCCCCEECCEEE		42.96-
1566PhosphorylationGRNIERVSFYLGFSI
CCCCCEEEEEEECCE		17.88-
1568PhosphorylationNIERVSFYLGFSIEG
CCCEEEEEEECCEEC		9.8222210691
1572PhosphorylationVSFYLGFSIEGPLAY
EEEEEECCEECCEEE		20.2422210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAM9L_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAM9L_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAM9L_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SAM9L_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAM9L_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1293, AND MASSSPECTROMETRY.

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