SAHH_RAT - dbPTM
SAHH_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAHH_RAT
UniProt AC P10760
Protein Name Adenosylhomocysteinase
Gene Name Ahcy
Organism Rattus norvegicus (Rat).
Sequence Length 432
Subcellular Localization Cytoplasm. Melanosome.
Protein Description Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine..
Protein Sequence MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Acetylation----MADKLPYKVAD
----CCCCCCCCHHH		41.6522902405
8AcetylationMADKLPYKVADIGLA
CCCCCCCCHHHHHHH		29.0722902405
43AcetylationREMYSASKPLKGARI
HHHHHCCCCCCCCCC		54.8322902405
43SuccinylationREMYSASKPLKGARI
HHHHHCCCCCCCCCC		54.8326843850
148PhosphorylationTKHPQLLSGIRGISE
CCCHHHHCCCCCCCC		40.5425575281
166AcetylationTGVHNLYKMMANGIL
CHHHHHHHHHHCCCE		25.9322902405
183PhosphorylationPAINVNDSVTKSKFD
CEEECCCCCCHHHCC		26.8721738781
185PhosphorylationINVNDSVTKSKFDNL
EECCCCCCHHHCCCC		33.2923984901
193PhosphorylationKSKFDNLYGCRESLI
HHHCCCCCCHHHHHH		22.0419605366
198PhosphorylationNLYGCRESLIDGIKR
CCCCHHHHHHHHHHH		15.9830181290
204AcetylationESLIDGIKRATDVMI
HHHHHHHHHHHHCEE		41.3222902405
318AcetylationLNENAVEKVNIKPQV
CCCCCEEECCCCHHH		33.7022902405
322AcetylationAVEKVNIKPQVDRYL
CEEECCCCHHHHHHH		24.9722902405
322SuccinylationAVEKVNIKPQVDRYL
CEEECCCCHHHHHHH		24.9726843850
389SuccinylationGVHFLPKKLDEAVAE
CEEECCHHHHHHHHH		60.2726843850
389UbiquitinationGVHFLPKKLDEAVAE
CEEECCHHHHHHHHH		60.27-
389AcetylationGVHFLPKKLDEAVAE
CEEECCHHHHHHHHH		60.2772631077
401AcetylationVAEAHLGKLNVKLTK
HHHHHHCHHHHHHEE		43.1622902405
405AcetylationHLGKLNVKLTKLTEK
HHCHHHHHHEECCHH		49.7322902405
408AcetylationKLNVKLTKLTEKQAQ
HHHHHHEECCHHHHH		64.9450079157
412AcetylationKLTKLTEKQAQYLGM
HHEECCHHHHHHCCC		45.7822902405
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAHH_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAHH_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAHH_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SAHH_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAHH_RAT

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Related Literatures of Post-Translational Modification

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