S7A14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S7A14_HUMAN
• UniProt AC: Q8TBB6
• Protein Name: Probable cationic amino acid transporter
• Gene Name: SLC7A14
• Organism: Homo sapiens (Human).
• Sequence Length: 771
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein . Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes.
• Protein Description: May be involved in arginine transport..
• Protein Sequence: MSGFFTSLDPRRVQWGAAWYAMHSRILRTKPVESMLEGTGTTTAHGTKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYWAEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPSLGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGKMDRPTAATGHTVTICVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVFVILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIWNSTLEISAREEALHQSTYQRYDVDDPFSVEEGFSYATEGESQEDWGGPTEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELDYSPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGFFTSLD ------CCCCCCCCC	44.29	24425749
6	Phosphorylation	--MSGFFTSLDPRRV --CCCCCCCCCHHHH	26.56	22673903
7	Phosphorylation	-MSGFFTSLDPRRVQ -CCCCCCCCCHHHHH	26.14	24043423
29	Phosphorylation	MHSRILRTKPVESML HHHHHHCCCCHHHHH	35.93	-
34	Phosphorylation	LRTKPVESMLEGTGT HCCCCHHHHHCCCCC	28.97	-
39	Phosphorylation	VESMLEGTGTTTAHG HHHHHCCCCCCCCCC	23.21	26074081
41	Phosphorylation	SMLEGTGTTTAHGTK HHHCCCCCCCCCCCC	22.32	26074081
42	Phosphorylation	MLEGTGTTTAHGTKL HHCCCCCCCCCCCCH	24.27	26074081
43	Phosphorylation	LEGTGTTTAHGTKLA HCCCCCCCCCCCCHH	19.25	26074081
47	Phosphorylation	GTTTAHGTKLAQVLT CCCCCCCCCHHHHHH	17.02	26074081
282	N-linked_Glycosylation	GEEAKNPNTSIPYAI CCHHCCCCCCCCHHH	56.71	UniProtKB CARBOHYD
283	Phosphorylation	EEAKNPNTSIPYAIT CHHCCCCCCCCHHHH	29.32	-
284	Phosphorylation	EAKNPNTSIPYAITA HHCCCCCCCCHHHHH	28.36	-
287	Phosphorylation	NPNTSIPYAITASLV CCCCCCCHHHHHHHH	14.68	-
290	Phosphorylation	TSIPYAITASLVICL CCCCHHHHHHHHHHH	11.30	-
403	Phosphorylation	ALLALLVSLRDLIEM HHHHHHHHHHHHHHH	20.04	24719451
465	Phosphorylation	DCEKEACSPVSEGDE HHHHCCCCCCCCCCC	35.07	29691806
468	Phosphorylation	KEACSPVSEGDEFSG HCCCCCCCCCCCCCC	38.97	29691806
474	Phosphorylation	VSEGDEFSGPATNTC CCCCCCCCCCCCCCC	41.65	29691806
488	Phosphorylation	CGAKNLPSLGDNEML CCCCCCCCCCCCCEE	48.42	27732954
504	Phosphorylation	GKSDKSTYNVNHPNY CCCCCCCCCCCCCCC	24.97	-
511	Phosphorylation	YNVNHPNYGTVDMTT CCCCCCCCCEEECCC	20.72	25884760
529	Phosphorylation	ADESENIYLIKLKKL CCCCCCEEEEEEHHH	17.60	-
541	Phosphorylation	KKLIGPHYYTMRIRL HHHHCCCEEEEEEEC	12.08	20049867
627	Phosphorylation	ENPKKLPYMAPCLPF CCCCCCCCCCCCCCC	19.15	-
676	N-linked_Glycosylation	YFGYGIWNSTLEISA HHHHCHHHHCCHHHH	24.16	UniProtKB CARBOHYD
691	Phosphorylation	REEALHQSTYQRYDV HHHHHHHHHCCCCCC	20.52	23312004
692	Phosphorylation	EEALHQSTYQRYDVD HHHHHHHHCCCCCCC	19.66	23312004
693	Phosphorylation	EALHQSTYQRYDVDD HHHHHHHCCCCCCCC	9.02	25884760
730	Phosphorylation	PTEDKGFYYQQMSDA CCCCCCCCCHHHHCH	14.72	25884760
731	Phosphorylation	TEDKGFYYQQMSDAK CCCCCCCCHHHHCHH	7.04	25884760
744	Phosphorylation	AKANGRTSSKAKSKS HHHCCCCCHHHHHHC	28.60	29759185
745	Phosphorylation	KANGRTSSKAKSKSK HHCCCCCHHHHHHCC	35.70	29759185
757	Phosphorylation	KSKHKQNSEALIAND HCCCCCCHHCHHCCC	23.04	-
768	Phosphorylation	IANDELDYSPE---- HCCCCCCCCCC----	38.46	25884760
769	Phosphorylation	ANDELDYSPE----- CCCCCCCCCC-----	23.40	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S7A14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S7A14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S7A14_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S7A14_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.