S6A17_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S6A17_RAT
• UniProt AC: P31662
• Protein Name: Sodium-dependent neutral amino acid transporter SLC6A17
• Gene Name: Slc6a17
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 727
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals.
• Protein Description: Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent..
• Protein Sequence: MPKNSKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGETGGKQKVAEEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSECPVIRNGTVAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTVCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYNVIMTVKEKQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAERYLYFPNWAMALLITLIAVATLPIPVVFILRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLESSSHPNGRYGSGYLLASTPESEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MPKNSKVTQREHS --CCCCCCCCCCCCC	59.71	-
13	Phosphorylation	KVTQREHSNEHVTES CCCCCCCCCHHHHHH	38.88	27097102
18	Phosphorylation	EHSNEHVTESVADLL CCCCHHHHHHHHHHH	25.17	28432305
20	Phosphorylation	SNEHVTESVADLLAL CCHHHHHHHHHHHHC	17.15	28432305
47	Ubiquitination	VAGETGGKQKVAEEE HCCCCCCCHHHHHHH	48.57	-
186	N-linked_Glycosylation	SECPVIRNGTVAVVE HHCCEEECCEEEEEC	39.09	-
377	Phosphorylation	NAEKILGYLNSNVLS CHHHHHHHHCCCCCC	10.16	-
393	N-linked_Glycosylation	DLIPPHVNFSHLTTK CCCCCCCCHHHCCCC	29.66	-
665	Phosphorylation	GRMMKDISNLEENDE CCCCCCHHCCCCCCC	45.56	30411139
679	Ubiquitination	ETRFILSKVPSEAPS CCCEEEECCCCCCCC	55.51	-
682	Phosphorylation	FILSKVPSEAPSPMP EEEECCCCCCCCCCC	49.75	27097102
686	Phosphorylation	KVPSEAPSPMPTHRS CCCCCCCCCCCCCHH	40.66	27097102
690	Phosphorylation	EAPSPMPTHRSYLGP CCCCCCCCCHHHCCC	24.54	28432305
699	Phosphorylation	RSYLGPGSTSPLESS HHHCCCCCCCCCCCC	28.92	27097102
700	Phosphorylation	SYLGPGSTSPLESSS HHCCCCCCCCCCCCC	40.03	27097102
701	Phosphorylation	YLGPGSTSPLESSSH HCCCCCCCCCCCCCC	29.23	30411139
705	Phosphorylation	GSTSPLESSSHPNGR CCCCCCCCCCCCCCC	44.84	27097102
706	Phosphorylation	STSPLESSSHPNGRY CCCCCCCCCCCCCCC	24.24	27097102
707	Phosphorylation	TSPLESSSHPNGRYG CCCCCCCCCCCCCCC	52.85	27097102
715	Phosphorylation	HPNGRYGSGYLLAST CCCCCCCCCEEEECC	18.48	28551015
721	Phosphorylation	GSGYLLASTPESEL- CCCEEEECCCCCCC-	44.45	30240740
722	Phosphorylation	SGYLLASTPESEL-- CCEEEECCCCCCC--	26.01	28551015
725	Phosphorylation	LLASTPESEL----- EEECCCCCCC-----	45.46	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S6A17_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S6A17_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S6A17_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of S6A17_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.