S6A13_HUMAN - dbPTM
S6A13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S6A13_HUMAN
UniProt AC Q9NSD5
Protein Name Sodium- and chloride-dependent GABA transporter 2
Gene Name SLC6A13
Organism Homo sapiens (Human).
Sequence Length 602
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport..
Protein Sequence MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MDSRVSGTTSNGE
--CCCCCCCCCCCCC		29.3423663014
8PhosphorylationMDSRVSGTTSNGETK
CCCCCCCCCCCCCEE		21.3923663014
9PhosphorylationDSRVSGTTSNGETKP
CCCCCCCCCCCCEEC		24.5823663014
10PhosphorylationSRVSGTTSNGETKPV
CCCCCCCCCCCEECC		42.5523663014
14PhosphorylationGTTSNGETKPVYPVM
CCCCCCCEECCCCEE		41.8923663014
18PhosphorylationNGETKPVYPVMEKKE
CCCEECCCCEEEEEC		9.9123663014
173N-linked_GlycosylationQKTNGSLNGTSENAT
HHHCCCCCCCCCCCC		54.09UniProtKB CARBOHYD
237PhosphorylationTGKVVYFTATFPYLM
CCCEEEEEECHHHHH		13.7019413330
239PhosphorylationKVVYFTATFPYLMLV
CEEEEEECHHHHHHH		23.2919413330
269N-linked_GlycosylationIQFYLYPNLTRLWDP
CEEEECCCCCCCCCC		40.25UniProtKB CARBOHYD
511PhosphorylationCTATFLFSLIKYTPL
HHHHHHHHHHHCCCC		31.1924719451
524PhosphorylationPLTYNKKYTYPWWGD
CCCCCCCCCCCCHHH		17.0826552605
525PhosphorylationLTYNKKYTYPWWGDA
CCCCCCCCCCCHHHH		31.8026552605
526PhosphorylationTYNKKYTYPWWGDAL
CCCCCCCCCCHHHHH		8.1826552605
540PhosphorylationLGWLLALSSMVCIPA
HHHHHHHHHCCHHHH		15.6926552605
541PhosphorylationGWLLALSSMVCIPAW
HHHHHHHHCCHHHHH		18.9826552605
549PhosphorylationMVCIPAWSLYRLGTL
CCHHHHHHHHHHCCC		20.0326552605
551PhosphorylationCIPAWSLYRLGTLKG
HHHHHHHHHHCCCCC		9.7726552605
583PhosphorylationQRNPAGPSAPATPRT
CCCCCCCCCCCCCCC		46.0628857561
587PhosphorylationAGPSAPATPRTSLLR
CCCCCCCCCCCHHHH		16.5528857561
590PhosphorylationSAPATPRTSLLRLTE
CCCCCCCCHHHHHHH		25.5728857561
591PhosphorylationAPATPRTSLLRLTEL
CCCCCCCHHHHHHHH		27.0424719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S6A13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S6A13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S6A13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S6A13_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S6A13_HUMAN

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Related Literatures of Post-Translational Modification

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