S6A11_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S6A11_RAT
• UniProt AC: P31647
• Protein Name: Sodium- and chloride-dependent GABA transporter 3
• Gene Name: Slc6a11
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 627
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals..
• Protein Sequence: MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKETHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AAEEARGSEALGGGG HHHHHHCCCCCCCCC	17.72	27097102
34	Phosphorylation	GGGGAAGTREARDKA CCCCCCCCHHHHHHH	22.17	27097102
182	N-linked_Glycosylation	CVEFQKLNFSNYSHV HEEEEECCCCCCCCC	45.39	-
185	N-linked_Glycosylation	FQKLNFSNYSHVSLQ EEECCCCCCCCCCCC	37.88	-
193	N-linked_Glycosylation	YSHVSLQNATSPVME CCCCCCCCCCCCHHH	50.94	-
581	Ubiquitination	TLPEKLQKLTVPSAD CCCHHHHHCCCCCHH	57.47	-
586	Phosphorylation	LQKLTVPSADLKMRG HHHCCCCCHHHHHCC	30.03	22673903
590	Ubiquitination	TVPSADLKMRGKLGA CCCCHHHHHCCCCCC	27.39	-
612	Ubiquitination	NDCEAKVKGDGTISA CCCEEEECCCCCEEE	51.05	-
623	Ubiquitination	TISAITEKETHF--- CEEEEEECCCCC---	60.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S6A11_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S6A11_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S6A11_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of S6A11_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.