S4A8_MOUSE - dbPTM
S4A8_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S4A8_MOUSE
UniProt AC Q8JZR6
Protein Name Electroneutral sodium bicarbonate exchanger 1
Gene Name Slc4a8 {ECO:0000312|EMBL:AAH30388.1, ECO:0000312|MGI:MGI:1928745}
Organism Mus musculus (Mouse).
Sequence Length 1089
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity..
Protein Sequence MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48PhosphorylationLEGHRTLYVGVRMPL
HCCCCEEEEEEECCC		8.4429514104
81PhosphorylationGGRGKGASQGEEGLE
CCCCCCCCCHHHHHH		47.5928066266
94PhosphorylationLEALAHDTPSQRVQF
HHHHCCCCHHHEEEE		18.2529899451
237PhosphorylationNLIPIVRSFAEVGKK
CHHHHHHHHHHHCCC		20.2223737553
246PhosphorylationAEVGKKQSDPHSMDR
HHHCCCCCCCCCCCC		63.0924899341
250PhosphorylationKKQSDPHSMDRDGQT
CCCCCCCCCCCCCCE		27.9729899451
257PhosphorylationSMDRDGQTVSPQSAT
CCCCCCCEECCCCCC		28.6028066266
259PhosphorylationDRDGQTVSPQSATNL
CCCCCEECCCCCCCC		22.1725521595
262PhosphorylationGQTVSPQSATNLEVK
CCEECCCCCCCCEEE		40.2125521595
264PhosphorylationTVSPQSATNLEVKNG
EECCCCCCCCEEECC		45.6528066266
277PhosphorylationNGVNCEHSPVDLSKV
CCCCCCCCCCCHHHC		12.3429899451
934AcetylationKLFGMPAKHQPDFIY
HHHCCCCCCCCCEEE		36.587615655
949AcetylationLRHVPLRKVHLFTLV
EECCCCCHHHHHHHH		41.517615665
1035UbiquitinationMLDIGGDKFPLESRK
HHHCCCCCCCCCHHH		52.7522790023
1045PhosphorylationLESRKLLSSPGKSSS
CCHHHCCCCCCCCCC		44.9421454597
1046PhosphorylationESRKLLSSPGKSSSF
CHHHCCCCCCCCCCC		37.3325521595
1050PhosphorylationLLSSPGKSSSFRCDP
CCCCCCCCCCCCCCH		36.8129899451
1051PhosphorylationLSSPGKSSSFRCDPS
CCCCCCCCCCCCCHH		36.6629899451
1052PhosphorylationSSPGKSSSFRCDPSE
CCCCCCCCCCCCHHH		24.6525521595
1058PhosphorylationSSFRCDPSEINISDE
CCCCCCHHHCCCCCC		37.5529899451
1076PhosphorylationTTVWKALSINSGNTK
CCEEEEEECCCCCCC		25.2822324799
1079PhosphorylationWKALSINSGNTKEKS
EEEEECCCCCCCCCC		31.5829514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S4A8_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S4A8_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S4A8_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S4A8_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S4A8_MOUSE

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Related Literatures of Post-Translational Modification

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