S4A10_HUMAN - dbPTM
S4A10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S4A10_HUMAN
UniProt AC Q6U841
Protein Name Sodium-driven chloride bicarbonate exchanger
Gene Name SLC4A10
Organism Homo sapiens (Human).
Sequence Length 1118
Subcellular Localization Cell membrane
Multi-pass membrane protein. Localizes to the basolateral membrane..
Protein Description Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity)..
Protein Sequence MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACVENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRHEKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQYSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDLLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTALWRNLLITADNSKDKESSFPSKSSPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationVDRGGTRSILKTHFE
CCCCCCCHHHHHHCC		31.9124719451
81PhosphorylationKRDRERDSGLEDGRE
HHHHHCCCCCCCCCC		52.0429691806
89 (in isoform 2)Phosphorylation-25.20-
89PhosphorylationGLEDGRESPSFDTPS
CCCCCCCCCCCCCHH		25.2022617229
91PhosphorylationEDGRESPSFDTPSQR
CCCCCCCCCCCHHHE		45.0618510355
94PhosphorylationRESPSFDTPSQRVQF
CCCCCCCCHHHEEEE		23.88-
158PhosphorylationGERWSKPYVATLSLH
CCCCCCCEEEEEEHH		13.37-
161PhosphorylationWSKPYVATLSLHSLF
CCCCEEEEEEHHHHH		13.56-
172PhosphorylationHSLFELRSCILNGTV
HHHHHHHHHHHCCEE		20.3822817900
183UbiquitinationNGTVLLDMHANTLEE
CCEEEEECCCCCHHH		3.0322817900
185UbiquitinationTVLLDMHANTLEEIA
EEEEECCCCCHHHHH		12.2222817900
213UbiquitinationNEDVRHRVHEALMKQ
CHHHHHHHHHHHHHH		3.8022817900
215UbiquitinationDVRHRVHEALMKQHH
HHHHHHHHHHHHHHH		40.4122817900
230PhosphorylationHQNQKKLTNRIPIVR
HHHHHHHHHCCCHHH		31.1929083192
238PhosphorylationNRIPIVRSFADIGKK
HCCCHHHHHHHHCCC		17.5622167270
238 (in isoform 2)Phosphorylation-17.56-
244UbiquitinationRSFADIGKKQSEPNS
HHHHHHCCCCCCCCC		48.2333845483
247PhosphorylationADIGKKQSEPNSMDK
HHHCCCCCCCCCCCC		64.9925849741
255UbiquitinationEPNSMDKNAGQVVSP
CCCCCCCCCCCCCCC		45.0733845483
261PhosphorylationKNAGQVVSPQSAPAC
CCCCCCCCCCCCCCC		20.5425332170
264PhosphorylationGQVVSPQSAPACVEN
CCCCCCCCCCCCCCC		39.3425849741
276PhosphorylationVENKNDVSRENSTVD
CCCCCCCCCCCCEEC		36.4225849741
276 (in isoform 2)Phosphorylation-36.4225849741
280 (in isoform 2)Phosphorylation-25.6725849741
280PhosphorylationNDVSRENSTVDFSKG
CCCCCCCCEECCCCC		25.6730266825
281PhosphorylationDVSRENSTVDFSKGL
CCCCCCCEECCCCCC		35.3630266825
285PhosphorylationENSTVDFSKGLGGQQ
CCCEECCCCCCCCCC		22.7323312004
287 (in isoform 3)Phosphorylation-28.4925849741
291 (in isoform 3)Phosphorylation-39.7625849741
353PhosphorylationVVAFVRLSPAVLLQG
HHHHEECCHHHHHHH		10.55-
368PhosphorylationLAEVPIPTRFLFILL
HHCCCCCCEEEEEHH		34.47-
375UbiquitinationTRFLFILLGPLGKGQ
CEEEEEHHCCCCCCH		5.9222817900
376UbiquitinationRFLFILLGPLGKGQQ
EEEEEHHCCCCCCHH		16.3722817900
377UbiquitinationFLFILLGPLGKGQQY
EEEEHHCCCCCCHHH		37.6022817900
378UbiquitinationLFILLGPLGKGQQYH
EEEHHCCCCCCHHHH		11.9822817900
384PhosphorylationPLGKGQQYHEIGRSI
CCCCCHHHHHHHHHH		8.11-
386UbiquitinationGKGQQYHEIGRSIAT
CCCHHHHHHHHHHHH		42.0522817900
387UbiquitinationKGQQYHEIGRSIATL
CCHHHHHHHHHHHHH		3.3722817900
388UbiquitinationGQQYHEIGRSIATLM
CHHHHHHHHHHHHHH		17.8222817900
389UbiquitinationQQYHEIGRSIATLMT
HHHHHHHHHHHHHHH		30.4722817900
390PhosphorylationQYHEIGRSIATLMTD
HHHHHHHHHHHHHHH		16.0320166139
390UbiquitinationQYHEIGRSIATLMTD
HHHHHHHHHHHHHHH		16.0322817900
393PhosphorylationEIGRSIATLMTDEVF
HHHHHHHHHHHHHHH		18.52-
396PhosphorylationRSIATLMTDEVFHDV
HHHHHHHHHHHHHHH		31.92-
405UbiquitinationEVFHDVAYKAKDRND
HHHHHHHHHCCCCCH		16.0122817900
406UbiquitinationVFHDVAYKAKDRNDL
HHHHHHHHCCCCCHH		38.9422817900
407UbiquitinationFHDVAYKAKDRNDLV
HHHHHHHCCCCCHHH		13.3022817900
408UbiquitinationHDVAYKAKDRNDLVS
HHHHHHCCCCCHHHC		53.7422817900
415PhosphorylationKDRNDLVSGIDEFLD
CCCCHHHCCHHHHHH		37.0126074081
417UbiquitinationRNDLVSGIDEFLDQV
CCHHHCCHHHHHHHC		3.4122817900
418UbiquitinationNDLVSGIDEFLDQVT
CHHHCCHHHHHHHCE		44.0922817900
419UbiquitinationDLVSGIDEFLDQVTV
HHHCCHHHHHHHCEE		46.3022817900
420UbiquitinationLVSGIDEFLDQVTVL
HHCCHHHHHHHCEEC		8.9322817900
425PhosphorylationDEFLDQVTVLPPGEW
HHHHHHCEECCCCCC		15.6426074081
435PhosphorylationPPGEWDPSIRIEPPK
CCCCCCCCCCCCCCC		23.2526074081
674N-linked_GlycosylationCNCVEPHNPSNGTLK
CCCCCCCCCCCCCHH		53.03-
677N-linked_GlycosylationVEPHNPSNGTLKEWR
CCCCCCCCCCHHHHH		49.0418061361
687N-linked_GlycosylationLKEWRESNISASDII
HHHHHHCCCCHHHHH		27.7318061361
697N-linked_GlycosylationASDIIWENLTVSECK
HHHHHHHCCCHHHHH		26.4718061361
755UbiquitinationTSRYFPTKVRSIVSD
HHCCCCHHHHHHHHH		35.57-
795PhosphorylationVPSVFKPTRDDRGWF
CCCCCCCCCCCCCCE		47.5228555341
928PhosphorylationGSSVFMTSILKFIPM
CCHHHHHHHHHHCCH		17.7124719451
939PhosphorylationFIPMPVLYGVFLYMG
HCCHHHHHHHHHHCC		16.1023532336
948PhosphorylationVFLYMGASSLKGIQF
HHHHCCCHHCCCCCH		30.4024719451
949PhosphorylationFLYMGASSLKGIQFF
HHHCCCHHCCCCCHH		33.3024719451
974PhosphorylationKHQPDFIYLRHVPLR
CCCCCEEEEECCCCC		9.55-
1013 (in isoform 2)Ubiquitination-1.9921906983
1033PhosphorylationLFTKRELSWLDDLMP
HCHHHHHHHHHHHCC		22.3529083192
1042PhosphorylationLDDLMPESKKKKLED
HHHHCCHHHHHHHHH		43.8529083192
1043UbiquitinationDDLMPESKKKKLEDA
HHHCCHHHHHHHHHH		67.93-
1043 (in isoform 1)Ubiquitination-67.9321906983
1057PhosphorylationAEKEEEQSMLAMEDE
HHHHHHHHHHCCCCC		21.0224076635
1085PhosphorylationDPSVINISDEMSKTA
CCCCEECCHHHCHHH		24.03-
1110PhosphorylationNSKDKESSFPSKSSP
CCCCCHHCCCCCCCC		42.1222468782
1113PhosphorylationDKESSFPSKSSPS--
CCHHCCCCCCCCC--		43.0629396449
1115PhosphorylationESSFPSKSSPS----
HHCCCCCCCCC----		52.3924076635
1116PhosphorylationSSFPSKSSPS-----
HCCCCCCCCC-----		32.6624076635
1118PhosphorylationFPSKSSPS-------
CCCCCCCC-------		55.6025332170
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S4A10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S4A10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S4A10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S4A10_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01390Sodium bicarbonate
Regulatory Network of S4A10_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, AND MASSSPECTROMETRY.

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