S45A4_HUMAN - dbPTM
S45A4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S45A4_HUMAN
UniProt AC Q5BKX6
Protein Name Solute carrier family 45 member 4
Gene Name SLC45A4
Organism Homo sapiens (Human).
Sequence Length 768
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFPDEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETESVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5 (in isoform 3)Phosphorylation-25.18-
5 (in isoform 2)Phosphorylation-25.18-
8 (in isoform 3)Phosphorylation-28.61-
8 (in isoform 2)Phosphorylation-28.61-
15 (in isoform 3)Phosphorylation-3.4130622161
15 (in isoform 2)Phosphorylation-3.4130622161
18 (in isoform 3)Phosphorylation-3.3230622161
18 (in isoform 2)Phosphorylation-3.3230622161
22 (in isoform 3)Phosphorylation-7.6230622161
22 (in isoform 2)Phosphorylation-7.6230622161
26 (in isoform 3)Phosphorylation-56.4630622161
26 (in isoform 2)Phosphorylation-56.4630622161
38PhosphorylationAEAENCETISEGSID
CCCCCCCCCCCCCCC		31.8123663014
40PhosphorylationAENCETISEGSIDRI
CCCCCCCCCCCCCCC		43.2423663014
43PhosphorylationCETISEGSIDRIPMR
CCCCCCCCCCCCCCC		19.7723663014
265PhosphorylationYSPQQERSAEEPGAL
CCHHHHHCCCCCCCC		39.0026471730
289PhosphorylationAFPDEVQSEHELALD
CCCHHHHCCCCHHCC		46.2026657352
296 (in isoform 3)Phosphorylation-47.5127251275
297PhosphorylationEHELALDYPDVDIMR
CCCHHCCCCCCCEEC		11.3726471730
305PhosphorylationPDVDIMRSKSDSALH
CCCCEECCCCCCCCC		21.0923898821
307PhosphorylationVDIMRSKSDSALHVP
CCEECCCCCCCCCCC		37.7425627689
309PhosphorylationIMRSKSDSALHVPDT
EECCCCCCCCCCCCC		39.5627422710
316PhosphorylationSALHVPDTALDLEPE
CCCCCCCCCCCCCCH		24.0523898821
333PhosphorylationFLHDIEPSIFHDASY
EECCCCCHHCCCCCC		25.7023898821
338 (in isoform 3)Phosphorylation-11.4624719451
339PhosphorylationPSIFHDASYPATPRS
CHHCCCCCCCCCCCC		37.3927422710
343PhosphorylationHDASYPATPRSTSQE
CCCCCCCCCCCCHHH		18.0925627689
346PhosphorylationSYPATPRSTSQELAK
CCCCCCCCCHHHHHH		33.3526657352
347PhosphorylationYPATPRSTSQELAKT
CCCCCCCCHHHHHHC		35.3928060719
348PhosphorylationPATPRSTSQELAKTK
CCCCCCCHHHHHHCH		23.9323663014
357 (in isoform 3)Phosphorylation-30.6924719451
361PhosphorylationTKLPRLATFLKEAAK
CHHHHHHHHHHHHHH		33.8123312004
364UbiquitinationPRLATFLKEAAKEDE
HHHHHHHHHHHHCCC		40.91-
368UbiquitinationTFLKEAAKEDETLLD
HHHHHHHHCCCCHHH		73.14-
372PhosphorylationEAAKEDETLLDNHLN
HHHHCCCCHHHHHCC		44.9621130716
373 (in isoform 3)Phosphorylation-5.4924719451
382UbiquitinationDNHLNEAKVPNGSGS
HHHCCCCCCCCCCCC		52.63-
387PhosphorylationEAKVPNGSGSPTKDA
CCCCCCCCCCCCCCC		42.6221130716
389PhosphorylationKVPNGSGSPTKDALG
CCCCCCCCCCCCCCC		30.9729396449
391PhosphorylationPNGSGSPTKDALGGY
CCCCCCCCCCCCCCC		43.1623312004
398PhosphorylationTKDALGGYTRVDTKP
CCCCCCCCEEEECCC		6.92-
403PhosphorylationGGYTRVDTKPSATSS
CCCEEEECCCCCCCH		41.8325002506
403 (in isoform 3)Phosphorylation-41.8324719451
404UbiquitinationGYTRVDTKPSATSSS
CCEEEECCCCCCCHH		32.29-
406PhosphorylationTRVDTKPSATSSSMR
EEEECCCCCCCHHHH		45.8129083192
408PhosphorylationVDTKPSATSSSMRRR
EECCCCCCCHHHHHH		33.2225002506
409PhosphorylationDTKPSATSSSMRRRR
ECCCCCCCHHHHHHH		21.8229083192
410PhosphorylationTKPSATSSSMRRRRH
CCCCCCCHHHHHHHH		24.6528985074
411PhosphorylationKPSATSSSMRRRRHA
CCCCCCHHHHHHHHH		18.9721712546
424PhosphorylationHAFRRQASSTFSYYG
HHHHHHCHHHHCCCC		22.9026657352
425PhosphorylationAFRRQASSTFSYYGK
HHHHHCHHHHCCCCC		36.1729978859
426PhosphorylationFRRQASSTFSYYGKL
HHHHCHHHHCCCCCC		17.6929978859
428PhosphorylationRQASSTFSYYGKLGS
HHCHHHHCCCCCCCC		19.9623186163
429PhosphorylationQASSTFSYYGKLGSH
HCHHHHCCCCCCCCH		16.4318083107
430PhosphorylationASSTFSYYGKLGSHC
CHHHHCCCCCCCCHH		13.4418083107
435PhosphorylationSYYGKLGSHCYRYRR
CCCCCCCCHHHEECC		22.33-
438PhosphorylationGKLGSHCYRYRRANA
CCCCCHHHEECCCCE		12.78-
452PhosphorylationAVVLIKPSRSMSDLY
EEEEECCCCCHHHHH		31.8022210691
454PhosphorylationVLIKPSRSMSDLYDM
EEECCCCCHHHHHHH		27.2922617229
456PhosphorylationIKPSRSMSDLYDMQK
ECCCCCHHHHHHHHH		26.2228450419
459PhosphorylationSRSMSDLYDMQKRQR
CCCHHHHHHHHHHHH		17.8529052541
463UbiquitinationSDLYDMQKRQRQHRH
HHHHHHHHHHHHHHH		43.81-
483PhosphorylationATTSSGDTESEEGEG
CCCCCCCCCCCCCCC		44.9625307156
485PhosphorylationTSSGDTESEEGEGET
CCCCCCCCCCCCCHH		42.9426471730
681 (in isoform 3)Phosphorylation-10.6527251275
728UbiquitinationEEAKEEQKGLSSPLA
HHHHHHHCCCCCCCC		66.16-
731PhosphorylationKEEQKGLSSPLAGEG
HHHHCCCCCCCCCCC		38.2826657352
732PhosphorylationEEQKGLSSPLAGEGR
HHHCCCCCCCCCCCC		29.0425159151
745 (in isoform 3)Methylation-68.03-
746UbiquitinationRAGGNSEKPTVLKLT
CCCCCCCCCCEEEEE		45.89-
746 (in isoform 3)Methylation-45.89-
746MethylationRAGGNSEKPTVLKLT
CCCCCCCCCCEEEEE		45.89-
751UbiquitinationSEKPTVLKLTRKEGL
CCCCCEEEEECCCCC		43.40-
755UbiquitinationTVLKLTRKEGLQGPV
CEEEEECCCCCCCCC		51.392190698
755 (in isoform 1)Ubiquitination-51.3921906983
764PhosphorylationGLQGPVETESVV---
CCCCCCCCCCCC---		33.5229514088
766PhosphorylationQGPVETESVV-----
CCCCCCCCCC-----		35.2829514088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S45A4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S45A4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S45A4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S45A4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S45A4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454, AND MASSSPECTROMETRY.

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