S3TC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S3TC1_HUMAN
• UniProt AC: Q8TE82
• Protein Name: SH3 domain and tetratricopeptide repeat-containing protein 1
• Gene Name: SH3TC1
• Organism: Homo sapiens (Human).
• Sequence Length: 1336
• Protein Sequence: MENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGFTHHCLANLLMDQAFWLLLPSEEEETAIQVHVDENALRLTHESLLIQEGPFFVLCPDHHVRVMTGPRDAGNGPQALRQASGAPQGEAAPETDSSPPSPSVSSEEVAVAAAPEPLIPFHQWALRIPQDPIDDAMGGPVMPGNPLMAVGLASALADFQGSGPEEMTFRGGDLIEILGAQVPSLPWCVGRHAASGRVGFVRSSLISMQGPVSELESAIFLNEEEKSFFSEGCFSEEDARQLLRRMSGTDVCSVYSLDSVEEAETEQPQEKEIPPPCLSLEPQETLQKVKNVLEQCKTCPGCPQEPASWGLCAASSDVSLQDPEEPSFCLEAEDDWEDPEALSSLLLFLNAPGYKASFRGLYDVALPWLSSVFRSFSDEEELTGRLAQARGAAKKAGLLMALARLCFLLGRLCSRRLKLSQARVYFEEALGALEGSFGDLFLVVAVYANLASIYRKQKNREKCAQVVPKAMALLLGTPDHICSTEAEGELLQLALRRAVGGQSLQAEARACFLLARHHVHLKQPEEALPFLERLLLLHRDSGAPEAAWLSDCYLLLADIYSRKCLPHLVLSCVKVASLRTRGSLAGSLRSVNLVLQNAPQPHSLPAQTSHYLRQALASLTPGTGQALRGPLYTSLAQLYSHHGCHGPAITFMTQAVEASAIAGVRAIVDHLVALAWLHVLHGQSPVALDILQSVRDAVVASEDQEGVIANMVAVALKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSLCNSPLEFDEETLYYVKVYLVLGDIIFYDLKDPFDAAGYYQLALAAAVDLGNKKAQLKIYTRLATIYHNFLLDREKSLFFYQKARTFATELNVRRVNLPPLPLCGWAPWLAPSHPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENLPAVT -------CCCCCCCC	35.55	22814378
8	Phosphorylation	MENLPAVTTEEPTPM CCCCCCCCCCCCCCC	30.51	29083192
9	Phosphorylation	ENLPAVTTEEPTPMG CCCCCCCCCCCCCCC	31.58	29083192
13	Phosphorylation	AVTTEEPTPMGRGPV CCCCCCCCCCCCCCC	29.23	29083192
34	Phosphorylation	STRDQVRTVVMRPSV CCHHHHEEEEECCCC	20.70	24719451
40	Phosphorylation	RTVVMRPSVSWEKAG EEEEECCCCCHHHCC	20.58	27251275
42	Phosphorylation	VVMRPSVSWEKAGPE EEECCCCCHHHCCHH	33.58	28857561
360	Phosphorylation	GRVGFVRSSLISMQG CCHHHHHHHHHCCCC	24.97	24275569
447	Ubiquitination	QETLQKVKNVLEQCK HHHHHHHHHHHHHHC	48.66	-
577	Phosphorylation	CSRRLKLSQARVYFE HHHCCCHHHHHHHHH	21.87	-
619	Ubiquitination	RKQKNREKCAQVVPK HHHHCHHHHHHHHHH	31.47	-
718	Phosphorylation	LLLADIYSRKCLPHL HHHHHHHCCCCHHHH	26.12	24719451
874	Ubiquitination	NMVAVALKRTGRTRQ HHHHHHHHHHCCCHH	37.87	-
934	Phosphorylation	LEAVRLFSRLPLGEC HHHHHHHHCCCCCCC	37.18	23403867
1037	Phosphorylation	LETISQLYLSLGTER HHHHHHHHHHHCCHH	6.14	-
1042	Phosphorylation	QLYLSLGTERAYKSA HHHHHHCCHHHHHHH	27.82	24719451
1047	Ubiquitination	LGTERAYKSALDYTK HCCHHHHHHHHHHHH	28.41	-
1048	Phosphorylation	GTERAYKSALDYTKR CCHHHHHHHHHHHHH	22.76	29978859
1052	Phosphorylation	AYKSALDYTKRSLGI HHHHHHHHHHHHHCE	18.27	29978859
1053	Phosphorylation	YKSALDYTKRSLGIF HHHHHHHHHHHHCEE	21.46	29978859
1054	Ubiquitination	KSALDYTKRSLGIFI HHHHHHHHHHHCEEE	33.49	-
1056	Phosphorylation	ALDYTKRSLGIFIDL HHHHHHHHHCEEEEC	32.29	29978859
1129	Ubiquitination	DGAWEREKAVSFYRD CCHHHHHHHHHHHHH	61.38	-
1248	Phosphorylation	VLGDIIFYDLKDPFD HHCCEEEECCCCCCC	15.23	24260401
1281	Phosphorylation	KAQLKIYTRLATIYH HHHHHHHHHHHHHHH	23.76	20049867
1287	Phosphorylation	YTRLATIYHNFLLDR HHHHHHHHHHHHCCH	6.07	20049867
1294	Methylation	YHNFLLDREKSLFFY HHHHHCCHHHHHHHH	53.89	115372805
1294	Dimethylation	YHNFLLDREKSLFFY HHHHHCCHHHHHHHH	53.89	-
1296	Ubiquitination	NFLLDREKSLFFYQK HHHCCHHHHHHHHHH	54.04	-
1303	Ubiquitination	KSLFFYQKARTFATE HHHHHHHHHHHHHHH	28.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S3TC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S3TC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S3TC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S3TC1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248, AND MASSSPECTROMETRY.
PubMed: 19690332