S38A3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S38A3_RAT
• UniProt AC: Q9JHZ9
• Protein Name: Sodium-coupled neutral amino acid transporter 3
• Gene Name: Slc38a3 {ECO:0000312|RGD:628620}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 504
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine and asparagine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission..
• Protein Sequence: MEIPRQTEMVELVPNGKHLEGLLPVGMPTADTQRAEDAQHCGEGKGFLQQSSSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEKPTPVWYMDGNYLVILVSVIIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLVNATGNFSHMVVVEEKSQLQSEPDTAEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIFYFRIMPTEKEPVRSTPKILALCFAAVGFLLMTMSLSFIITDWVSGTSQHGGNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	GKGFLQQSSSKEPHF CCCHHHCCCCCCCCE	24.50	27097102
52	Phosphorylation	KGFLQQSSSKEPHFT CCHHHCCCCCCCCEE	40.88	27097102
53	Phosphorylation	GFLQQSSSKEPHFTD CHHHCCCCCCCCEEC	46.41	27097102
54	Ubiquitination	FLQQSSSKEPHFTDF HHHCCCCCCCCEECC	76.77	-
59	Phosphorylation	SSKEPHFTDFEGKTS CCCCCCEECCCCCCC	36.42	27097102
73	N-linked_Glycosylation	SFGMSVFNLSNAIMG CCCCHHHCCCHHHHH	40.16	-
247	N-linked_Glycosylation	PLAHNLVNATGNFSH CCHHHECCCCCCCCE	34.64	-
251	N-linked_Glycosylation	NLVNATGNFSHMVVV HECCCCCCCCEEEEE	30.78	-
323	N-linked_Glycosylation	RKMQHISNLSIAVMY HHHHHHHHHHHHHHH	36.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
52	S	Phosphorylation	Kinase	PRKACA	P27791	GPS
52	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
52	S	Phosphorylation	Kinase	PRKCG	P05129	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S38A3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S38A3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of S38A3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.