S27A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S27A1_HUMAN
• UniProt AC: Q6PCB7
• Protein Name: Long-chain fatty acid transport protein 1 {ECO:0000305}
• Gene Name: SLC27A1 {ECO:0000312|HGNC:HGNC:10995}
• Organism: Homo sapiens (Human).
• Sequence Length: 646
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Endomembrane system ; Single-pass membrane protein . Cytoplasm . Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pat
• Protein Description: Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. [PubMed: 28178239 Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity]
• Protein Sequence: MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	APGAGAASVVSLALL CCCHHHHHHHHHHHH	23.63	26074081
13	Phosphorylation	AGAASVVSLALLWLL HHHHHHHHHHHHHHH	13.03	26074081
199	Phosphorylation	VSGHLGKSLIKFCSG HHCHHHHHHHHHHCC	33.26	24719451
202	Ubiquitination	HLGKSLIKFCSGDLG HHHHHHHHHHCCCCC	45.68	29967540
225	Ubiquitination	HLLDPLLKEASTAPL HHHHHHHHHCCCCCH	59.94	29967540
228	Phosphorylation	DPLLKEASTAPLAQI HHHHHHCCCCCHHHC	26.62	25850435
229	Phosphorylation	PLLKEASTAPLAQIP HHHHHCCCCCHHHCC	39.07	25850435
237	Phosphorylation	APLAQIPSKGMDDRL CCHHHCCCCCCCCCE	43.39	24719451
238	Acetylation	PLAQIPSKGMDDRLF CHHHCCCCCCCCCEE	53.55	30592437
246	Phosphorylation	GMDDRLFYIYTSGTT CCCCCEEEEEECCCC	9.52	-
248	Phosphorylation	DDRLFYIYTSGTTGL CCCEEEEEECCCCCC	5.40	-
266	Phosphorylation	AIVVHSRYYRMAAFG EEEEECCHHHHHHHC	9.84	-
267	Phosphorylation	IVVHSRYYRMAAFGH EEEECCHHHHHHHCC	7.87	-
346	Malonylation	EICRYLLKQPVREAE HHHHHHHHCCHHHHH	50.38	26320211
417	Phosphorylation	SRILPHVYPIRLVKV CCCCCCEEEEEEEEE	7.01	23663014
428	Phosphorylation	LVKVNEDTMELLRDA EEEECHHHHHHHHHC	13.33	23403867
468	Phosphorylation	RRFDGYVSESATSKK HHCCCCCCCCCCCCH	19.83	-
474	Ubiquitination	VSESATSKKIAHSVF CCCCCCCCHHHHHHH	43.79	30230243
475	Ubiquitination	SESATSKKIAHSVFS CCCCCCCHHHHHHHC	44.91	29967540
501	Phosphorylation	LVMDELGYMYFRDRS EEEECCCCEEEECCC	10.98	22817900
529	Phosphorylation	TEVEGVLSRLLGQTD HHHHHHHHHHHCCCC	20.62	24719451
569	Phosphorylation	LLDPNAIYQELQKVL CCCHHHHHHHHHHHH	8.10	27642862
593	Phosphorylation	RLLPQVDTTGTFKIQ HHCCCCCCCCCEEEE	28.41	28857561
594	Phosphorylation	LLPQVDTTGTFKIQK HCCCCCCCCCEEEEE	29.75	28857561
596	Phosphorylation	PQVDTTGTFKIQKTR CCCCCCCCEEEEEHH	21.47	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S27A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S27A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S27A1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S27A1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.