S27A1_HUMAN - dbPTM
S27A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S27A1_HUMAN
UniProt AC Q6PCB7
Protein Name Long-chain fatty acid transport protein 1 {ECO:0000305}
Gene Name SLC27A1 {ECO:0000312|HGNC:HGNC:10995}
Organism Homo sapiens (Human).
Sequence Length 646
Subcellular Localization Cell membrane
Single-pass membrane protein . Endomembrane system
Single-pass membrane protein . Cytoplasm . Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pat
Protein Description Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. [PubMed: 28178239 Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity]
Protein Sequence MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationAPGAGAASVVSLALL
CCCHHHHHHHHHHHH
23.6326074081
13PhosphorylationAGAASVVSLALLWLL
HHHHHHHHHHHHHHH
13.0326074081
199PhosphorylationVSGHLGKSLIKFCSG
HHCHHHHHHHHHHCC
33.2624719451
202UbiquitinationHLGKSLIKFCSGDLG
HHHHHHHHHHCCCCC
45.6829967540
225UbiquitinationHLLDPLLKEASTAPL
HHHHHHHHHCCCCCH
59.9429967540
228PhosphorylationDPLLKEASTAPLAQI
HHHHHHCCCCCHHHC
26.6225850435
229PhosphorylationPLLKEASTAPLAQIP
HHHHHCCCCCHHHCC
39.0725850435
237PhosphorylationAPLAQIPSKGMDDRL
CCHHHCCCCCCCCCE
43.3924719451
238AcetylationPLAQIPSKGMDDRLF
CHHHCCCCCCCCCEE
53.5530592437
246PhosphorylationGMDDRLFYIYTSGTT
CCCCCEEEEEECCCC
9.52-
248PhosphorylationDDRLFYIYTSGTTGL
CCCEEEEEECCCCCC
5.40-
266PhosphorylationAIVVHSRYYRMAAFG
EEEEECCHHHHHHHC
9.84-
267PhosphorylationIVVHSRYYRMAAFGH
EEEECCHHHHHHHCC
7.87-
346MalonylationEICRYLLKQPVREAE
HHHHHHHHCCHHHHH
50.3826320211
417PhosphorylationSRILPHVYPIRLVKV
CCCCCCEEEEEEEEE
7.0123663014
428PhosphorylationLVKVNEDTMELLRDA
EEEECHHHHHHHHHC
13.3323403867
468PhosphorylationRRFDGYVSESATSKK
HHCCCCCCCCCCCCH
19.83-
474UbiquitinationVSESATSKKIAHSVF
CCCCCCCCHHHHHHH
43.7930230243
475UbiquitinationSESATSKKIAHSVFS
CCCCCCCHHHHHHHC
44.9129967540
501PhosphorylationLVMDELGYMYFRDRS
EEEECCCCEEEECCC
10.9822817900
529PhosphorylationTEVEGVLSRLLGQTD
HHHHHHHHHHHCCCC
20.6224719451
569PhosphorylationLLDPNAIYQELQKVL
CCCHHHHHHHHHHHH
8.1027642862
593PhosphorylationRLLPQVDTTGTFKIQ
HHCCCCCCCCCEEEE
28.4128857561
594PhosphorylationLLPQVDTTGTFKIQK
HCCCCCCCCCEEEEE
29.7528857561
596PhosphorylationPQVDTTGTFKIQKTR
CCCCCCCCEEEEEHH
21.4728857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S27A1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S27A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S27A1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S27A1_HUMAN !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S27A1_HUMAN

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Related Literatures of Post-Translational Modification

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