S22AH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22AH_HUMAN
• UniProt AC: Q8WUG5
• Protein Name: Solute carrier family 22 member 17
• Gene Name: SLC22A17
• Organism: Homo sapiens (Human).
• Sequence Length: 538
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Vacuole membrane ; Multi-pass membrane protein . Upon LCN2-binding, it is internalized.
• Protein Description: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)..
• Protein Sequence: MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	N-linked_Glycosylation	HYGAFPPNASGWEQP CCCCCCCCCCCCCCC	47.15	UniProtKB CARBOHYD
32	N-linked_Glycosylation	SGWEQPPNASGVSVA CCCCCCCCCCCCHHH	54.12	UniProtKB CARBOHYD
134	Phosphorylation	RRGIVLLTLGLVGPC CCCEEEEEECCCCCC	18.02	24043423
150	Phosphorylation	VGGAAAGSSTGVMAL CCHHHCCCHHHHHHH	21.72	24043423
151	Phosphorylation	GGAAAGSSTGVMALR CHHHCCCHHHHHHHH	28.41	24043423
152	Phosphorylation	GAAAGSSTGVMALRF HHHCCCHHHHHHHHH	35.18	24043423
496	Phosphorylation	SIMLLPETKRKLLPE HHHCCHHHHHHHHHH	33.92	-
515	Phosphorylation	GELCRRPSLLRQPPP CCCCCCHHHHCCCCC	37.92	23312004
533	Phosphorylation	DHVPLLATPNPAL-- CCCCEECCCCCCC--	24.46	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22AH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22AH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22AH_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S22AH_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.