S22A4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S22A4_HUMAN
• UniProt AC: Q9H015
• Protein Name: Solute carrier family 22 member 4
• Gene Name: SLC22A4
• Organism: Homo sapiens (Human).
• Sequence Length: 551
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET)..
• Protein Sequence: MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	CRVPDAANLSSAWRN CCCCCCCCCCHHHHC	42.02	UniProtKB CARBOHYD
57	N-linked_Glycosylation	CRVPDAANLSSAWRN CCCCCCCCCCHHHHC	42.02	19349973
64	N-linked_Glycosylation	NLSSAWRNNSVPLRL CCCHHHHCCCCCCEE	34.13	UniProtKB CARBOHYD
88	Phosphorylation	CSRYRLATIANFSAL CCHHHHEEECCHHHC	25.80	-
91	N-linked_Glycosylation	YRLATIANFSALGLE HHHEEECCHHHCCCC	27.79	UniProtKB CARBOHYD
91	N-linked_Glycosylation	YRLATIANFSALGLE HHHEEECCHHHCCCC	27.79	19349973
93	Phosphorylation	LATIANFSALGLEPG HEEECCHHHCCCCCC	23.53	-
237	Phosphorylation	FSTLGVCTFFAVGYM HHHHCHHHHHHHHHH	21.27	26503514
243	Phosphorylation	CTFFAVGYMLLPLFA HHHHHHHHHHHHHHH	4.31	26503514
251	Phosphorylation	MLLPLFAYFIRDWRM HHHHHHHHHHHHHHH	7.69	26503514
286	Phosphorylation	ESPRWLISQRRFREA CCCHHHHHHHHHHHH	18.57	24719451
468	Phosphorylation	VGVTSTASRVGSIIA CCCCCCHHHHHHHHH	27.82	-
534	Phosphorylation	WFRSGKKTRDSMETE HHHCCCCCCCCCCCC	43.10	28857561
537	Phosphorylation	SGKKTRDSMETEENP CCCCCCCCCCCCCCC	18.41	28857561
540	Phosphorylation	KTRDSMETEENPKVL CCCCCCCCCCCCCEE	39.70	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S22A4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S22A4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S22A4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of S22A4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00286: Crohn's disease
• OMIM Disease
• 180300: Rheumatoid arthritis (RA)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00594: Amiloride
• DB00345: Aminohippurate
• DB01053: Benzylpenicillin
• DB00122: Choline
• DB00501: Cimetidine
• DB00575: Clonidine
• DB01151: Desipramine
• DB00536: Guanidine
• DB00458: Imipramine
• DB00332: Ipratropium bromide
• DB00125: L-Arginine
• DB00583: L-Carnitine
• DB00123: L-Lysine
• DB01137: Levofloxacin
• DB06691: Mepyramine
• DB00184: Nicotine
• DB01165: Ofloxacin
• DB01035: Procainamide
• DB00908: Quinidine
• DB00468: Quinine
• DB00127: Spermine
• DB00624: Testosterone
• DB01409: Tiotropium
• DB00661: Verapamil