S20A2_RAT - dbPTM
S20A2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S20A2_RAT
UniProt AC Q63488
Protein Name Sodium-dependent phosphate transporter 2
Gene Name Slc20a2
Organism Rattus norvegicus (Rat).
Sequence Length 656
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Functions as a retroviral receptor (By similarity)..
Protein Sequence MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPVFKELPGAKASDDSAVPLTSLAGEAAGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDKGPEEKPAQENNYRLLRRNNSYTCYTAAICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELTDPDQPHEDPAEDEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFIAWFVTVPVAGLFSAAIMALLMYICGFVSSSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81N-linked_GlycosylationIIDVNLYNETVETLM
CCEEECCCHHHHHHH		41.45-
250PhosphorylationAGRLEKESALSRASD
HHHHHHHHHHHHHCH		45.6525403869
253PhosphorylationLEKESALSRASDESL
HHHHHHHHHHCHHHH		26.0525403869
256PhosphorylationESALSRASDESLRKV
HHHHHHHCHHHHHHH		40.5825403869
259PhosphorylationLSRASDESLRKVQEA
HHHHCHHHHHHHHHH		38.1625403869
262UbiquitinationASDESLRKVQEAESP
HCHHHHHHHHHHCCC		54.27-
268PhosphorylationRKVQEAESPVFKELP
HHHHHHCCCHHHCCC		33.1527097102
272UbiquitinationEAESPVFKELPGAKA
HHCCCHHHCCCCCCC		59.58-
316PhosphorylationASYGRALSMTHGSAK
CCHHCCCCCCCCCCC		22.2029779826
318PhosphorylationYGRALSMTHGSAKSP
HHCCCCCCCCCCCCC		21.5123984901
321PhosphorylationALSMTHGSAKSPISN
CCCCCCCCCCCCCCC		25.5627097102
324PhosphorylationMTHGSAKSPISNGTF
CCCCCCCCCCCCCEE		27.4722108457
327PhosphorylationGSAKSPISNGTFGFE
CCCCCCCCCCEECCE		32.3725575281
330PhosphorylationKSPISNGTFGFEGHM
CCCCCCCEECCEEEE		25.4925575281
344PhosphorylationMRNDGHVYHTVHKDS
ECCCCCEEEEEECCC		6.0125575281
346PhosphorylationNDGHVYHTVHKDSGL
CCCCEEEEEECCCCH		13.4528432305
351PhosphorylationYHTVHKDSGLYKDLL
EEEEECCCCHHHHHH		35.1925575281
354PhosphorylationVHKDSGLYKDLLHKI
EECCCCHHHHHHHHH		13.1425575281
377PhosphorylationKPAQENNYRLLRRNN
CCCCCCCCHHHHHCC		17.7722276854
385PhosphorylationRLLRRNNSYTCYTAA
HHHHHCCCCEEEEEE		25.9323984901
386PhosphorylationLLRRNNSYTCYTAAI
HHHHCCCCEEEEEEE		11.7123984901
387PhosphorylationLRRNNSYTCYTAAIC
HHHCCCCEEEEEEEC		10.0023984901
389PhosphorylationRNNSYTCYTAAICGM
HCCCCEEEEEEECCC		7.5123984901
390PhosphorylationNNSYTCYTAAICGMP
CCCCEEEEEEECCCE		16.2623984901
405PhosphorylationVHATFRASDTSSAPE
EEEEEECCCCCCCCC		36.8528432305
407PhosphorylationATFRASDTSSAPEDS
EEEECCCCCCCCCCH		23.3028432305
408PhosphorylationTFRASDTSSAPEDSE
EEECCCCCCCCCCHH		29.5028432305
409PhosphorylationFRASDTSSAPEDSEK
EECCCCCCCCCCHHH		50.3528432305
414PhosphorylationTSSAPEDSEKLVGDT
CCCCCCCHHHHCCCC		34.6628432305
416UbiquitinationSAPEDSEKLVGDTVS
CCCCCHHHHCCCCCC		53.04-
421PhosphorylationSEKLVGDTVSYSKKR
HHHHCCCCCCCCCCC		12.8628432305
423PhosphorylationKLVGDTVSYSKKRLR
HHCCCCCCCCCCCCC		26.2727097102
424PhosphorylationLVGDTVSYSKKRLRY
HCCCCCCCCCCCCCC		21.8523984901
425PhosphorylationVGDTVSYSKKRLRYD
CCCCCCCCCCCCCCC		24.9727097102
459PhosphorylationGVEMRLASELTDPDQ
CEEEEEEHHCCCCCC		37.4225575281
462PhosphorylationMRLASELTDPDQPHE
EEEEHHCCCCCCCCC		41.2425575281
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S20A2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S20A2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S20A2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S20A2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S20A2_RAT

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Related Literatures of Post-Translational Modification

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