S20A1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S20A1_RAT
• UniProt AC: Q9JJP0
• Protein Name: Sodium-dependent phosphate transporter 1
• Gene Name: Slc20a1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 681
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification..
• Protein Sequence: MASTLAPITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSALLGAKVSETIRKGLIDVEKYNATQDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGIKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTIGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLMEKKNNLKDHEETKMAPGDVENRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPERERLPMDLKEETNIDGTINGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGDEMETLTWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAEMGLGDRKGSSGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYETRDVTTKEATPIWLLLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASAFTVVVASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKHIILPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
268	Phosphorylation	KIEREVKSSPSESPL HHHHHHHCCCCCCCC	53.29	27097102
269	Phosphorylation	IEREVKSSPSESPLM HHHHHHCCCCCCCCH	27.08	27097102
271	Phosphorylation	REVKSSPSESPLMEK HHHHCCCCCCCCHHC	53.29	27097102
273	Phosphorylation	VKSSPSESPLMEKKN HHCCCCCCCCHHCCC	27.89	29779826
391	Ubiquitination	HKDSGLYKELLHKLH ECCCCHHHHHHHHHH	47.10	-
419	Phosphorylation	KPLRRNNSYTSYTMA CCCCCCCCCCCEEEE	33.08	23984901
420	Phosphorylation	PLRRNNSYTSYTMAI CCCCCCCCCCEEEEE	11.22	23984901
421	Phosphorylation	LRRNNSYTSYTMAIC CCCCCCCCCEEEEEC	18.32	23984901
422	Phosphorylation	RRNNSYTSYTMAICG CCCCCCCCEEEEECC	15.46	23984901
423	Phosphorylation	RNNSYTSYTMAICGM CCCCCCCEEEEECCC	7.85	23984901
424	Phosphorylation	NNSYTSYTMAICGMP CCCCCCEEEEECCCC	10.41	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S20A1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S20A1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S20A1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of S20A1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.