| UniProt ID | S1PR3_HUMAN | |
|---|---|---|
| UniProt AC | Q99500 | |
| Protein Name | Sphingosine 1-phosphate receptor 3 | |
| Gene Name | S1PR3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 378 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.. | |
| Protein Sequence | MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | N-linked_Glycosylation | RLQPVRGNETLREHY CCCCCCCCHHHHHHH | 28.63 | UniProtKB CARBOHYD | |
| 92 | Phosphorylation | DLLAGIAYKVNILMS HHHHHHHHHHHHHHC | 17.35 | 26330541 | |
| 99 | Phosphorylation | YKVNILMSGKKTFSL HHHHHHHCCCCEEEE | 43.97 | 24719451 | |
| 117 | Phosphorylation | VWFLREGSMFVALGA EEECCCCCEEEEECH | 12.32 | 23532336 | |
| 291 | Phosphorylation | IVLAVLNSAMNPVIY HHHHHHHHCCCHHHH | 25.41 | 27732954 | |
| 298 | Phosphorylation | SAMNPVIYTLASKEM HCCCHHHHHHCCHHH | 8.92 | 27732954 | |
| 299 | Phosphorylation | AMNPVIYTLASKEMR CCCHHHHHHCCHHHH | 12.53 | 27732954 | |
| 302 | Phosphorylation | PVIYTLASKEMRRAF HHHHHHCCHHHHHHH | 32.06 | 27732954 | |
| 326 | Phosphorylation | RGRGARASPIQPALD CCCCCCCCCCCCCCC | 19.58 | 30266825 | |
| 335 | Phosphorylation | IQPALDPSRSKSSSS CCCCCCCCCCCCCCC | 49.18 | 29255136 | |
| 337 | Phosphorylation | PALDPSRSKSSSSNN CCCCCCCCCCCCCCC | 41.02 | 24173317 | |
| 348 | Phosphorylation | SSNNSSHSPKVKEDL CCCCCCCCCCCCCCC | 28.50 | 26329039 | |
| 362 | Phosphorylation | LPHTAPSSCIMDKNA CCCCCCHHHCCCCCH | 13.45 | 28857561 | |
| 367 | Ubiquitination | PSSCIMDKNAALQNG CHHHCCCCCHHHHCC | 30.98 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S1PR3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S1PR3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S1PR3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S1PR3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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