S19A1_HUMAN - dbPTM
S19A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S19A1_HUMAN
UniProt AC P41440
Protein Name Folate transporter 1
Gene Name SLC19A1
Organism Homo sapiens (Human).
Sequence Length 591
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump..
Protein Sequence MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVPSSPAV
-------CCCCCCCC		10.1122814378
4Phosphorylation----MVPSSPAVEKQ
----CCCCCCCCCCC		37.2325159151
5Phosphorylation---MVPSSPAVEKQV
---CCCCCCCCCCCC		15.7123401153
10UbiquitinationPSSPAVEKQVPVEPG
CCCCCCCCCCCCCCC		50.4221890473
35PhosphorylationLVCYLCFYGFMAQIR
HHHHHHHHHHHHHCC		14.41-
51PhosphorylationGESFITPYLLGPDKN
CCCCCCHHHCCCCCC		13.10-
58N-linked_GlycosylationYLLGPDKNFTREQVT
HHCCCCCCCCHHHHC		51.409767079
58N-linked_GlycosylationYLLGPDKNFTREQVT
HHCCCCCCCCHHHHC		51.409767079
222PhosphorylationDDRGRCETSASELER
CCCCCCCCCHHHHHH		32.9723401153
223PhosphorylationDRGRCETSASELERM
CCCCCCCCHHHHHHH		13.9129255136
225PhosphorylationGRCETSASELERMNP
CCCCCCHHHHHHHCC		42.3419664994
237UbiquitinationMNPGPGGKLGHALRV
HCCCCCCHHHHHHHH		58.1521890473
237UbiquitinationMNPGPGGKLGHALRV
HCCCCCCHHHHHHHH		58.1521890473
237UbiquitinationMNPGPGGKLGHALRV
HCCCCCCHHHHHHHH		58.1521890473
246S-palmitoylationGHALRVACGDSVLAR
HHHHHHHCCHHHHHH		5.9429575903
305PhosphorylationTTNSARVYNGAADAA
CCCCCCCCCCHHHHH		11.43-
335PhosphorylationKIRWARWSKLLIAGV
HHHHHHHHHHHHHHC		14.10-
435PhosphorylationVRKQFQLYSVYFLIL
HHHHHHHHHHHHHHH		5.8224043423
436PhosphorylationRKQFQLYSVYFLILS
HHHHHHHHHHHHHHH		20.9524043423
438PhosphorylationQFQLYSVYFLILSII
HHHHHHHHHHHHHHH		6.1724043423
443PhosphorylationSVYFLILSIIYFLGA
HHHHHHHHHHHHHHH		10.4324043423
446PhosphorylationFLILSIIYFLGAMLD
HHHHHHHHHHHHHHH		7.3524043423
474PhosphorylationPPAQGLRSAAEEKAA
CCHHHHHHHHHHHHH		36.5523917254
479UbiquitinationLRSAAEEKAAQALSV
HHHHHHHHHHHHHCC		40.2921890473
479UbiquitinationLRSAAEEKAAQALSV
HHHHHHHHHHHHHCC		40.2921890473
485PhosphorylationEKAAQALSVQDKGLG
HHHHHHHCCCCCCCC		22.2828985074
489UbiquitinationQALSVQDKGLGGLQP
HHHCCCCCCCCCCCC		38.662190698
499PhosphorylationGGLQPAQSPPLSPED
CCCCCCCCCCCCHHH		30.5025159151
503PhosphorylationPAQSPPLSPEDSLGA
CCCCCCCCHHHCCCC		31.8329255136
507PhosphorylationPPLSPEDSLGAVGPA
CCCCHHHCCCCCCCC		27.3429255136
515PhosphorylationLGAVGPASLEQRQSD
CCCCCCCCHHHHHCC		35.2629255136
521PhosphorylationASLEQRQSDPYLAQA
CCHHHHHCCCCHHCC		42.6226074081
524PhosphorylationEQRQSDPYLAQAPAP
HHHHCCCCHHCCCCC		21.4726074081
550O-linked_GlycosylationPSPCTLCSAQASGPE
CCCCCCCCCCCCCHH		26.91OGP
583PhosphorylationLGLQCLPSDGVQNVN
HCCEECCCCCCCCCC		33.7625159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S19A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S19A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S19A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S19A1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D05589 Pralatrexate (USAN/INN); 10-Propargyl-10-deazaaminopterin
DrugBank
DB00563Methotrexate
DB06813Pralatrexate
Regulatory Network of S19A1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.

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