| UniProt ID | S17A4_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y2C5 | |
| Protein Name | Probable small intestine urate exporter | |
| Gene Name | SLC17A4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 497 | |
| Subcellular Localization |
Apical cell membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein . Apical in the intestinal brush border. |
|
| Protein Description | Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).. | |
| Protein Sequence | MSTGPDVKATVGDISSDGNLNVAQEECSRKGFCSVRHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANAGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQDCSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSHSMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | N-linked_Glycosylation | ALILQLCNFSIYTQQ HHHHHHHCCCCEECC | 42.14 | UniProtKB CARBOHYD | |
| 56 | N-linked_Glycosylation | SIYTQQMNLSIAIPA CCEECCCCCEEEEEE | 26.71 | UniProtKB CARBOHYD | |
| 58 | Phosphorylation | YTQQMNLSIAIPAMV EECCCCCEEEEEECC | 12.64 | 24043423 | |
| 66 | N-linked_Glycosylation | IAIPAMVNNTAPPSQ EEEEECCCCCCCCCC | 27.35 | UniProtKB CARBOHYD | |
| 68 | Phosphorylation | IPAMVNNTAPPSQPN EEECCCCCCCCCCCC | 35.02 | 24043423 | |
| 72 | Phosphorylation | VNNTAPPSQPNASTE CCCCCCCCCCCCCCC | 58.15 | 24043423 | |
| 75 | N-linked_Glycosylation | TAPPSQPNASTERPS CCCCCCCCCCCCCCC | 38.60 | UniProtKB CARBOHYD | |
| 77 | Phosphorylation | PPSQPNASTERPSTD CCCCCCCCCCCCCCC | 37.12 | 24043423 | |
| 78 | Phosphorylation | PSQPNASTERPSTDS CCCCCCCCCCCCCCC | 33.34 | 24043423 | |
| 90 | N-linked_Glycosylation | TDSQGYWNETLKEFK CCCCCCHHHHHHHHH | 24.72 | UniProtKB CARBOHYD | |
| 282 | Phosphorylation | QDCSPGWSLPIRAMI CCCCCCCCCCHHHHH | 30.13 | 24719451 | |
| 466 | Phosphorylation | WRNVFLLSAAVNISG HHHHHHHHHHHHCHH | 19.14 | 25278378 | |
| 472 | Phosphorylation | LSAAVNISGLVFYLI HHHHHHCHHHHHHHH | 22.37 | 25278378 | |
| 477 | Phosphorylation | NISGLVFYLIFGRAD HCHHHHHHHHHCCCC | 7.45 | 25278378 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S17A4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S17A4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S17A4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of S17A4_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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