S12A5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S12A5_MOUSE
• UniProt AC: Q91V14
• Protein Name: Solute carrier family 12 member 5
• Gene Name: Slc12a5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1138
• Subcellular Localization: Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.
• Protein Description: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation..
• Protein Sequence: MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	22.51	20415495
6	Phosphorylation	--MSRRFTVTSLPPA --CCCCEEECCCCCC	22.51	19060867
8	Phosphorylation	MSRRFTVTSLPPAAS CCCCEEECCCCCCHH	22.84	19060867
9	Phosphorylation	SRRFTVTSLPPAASA CCCEEECCCCCCHHH	34.24	19060867
15	Phosphorylation	TSLPPAASAASADPE CCCCCCHHHHCCCHH	26.86	30635358
18	Phosphorylation	PPAASAASADPESRR CCCHHHHCCCHHHHC	32.68	30635358
23	Phosphorylation	AASADPESRRHSVAD HHCCCHHHHCCCCCC	39.75	30635358
27	Phosphorylation	DPESRRHSVADPRRL CHHHHCCCCCCCCCC	19.72	29899451
48	Phosphorylation	GDGNPKESSPFINST CCCCCCCCCCCCCCC	49.81	24925903
49	Phosphorylation	DGNPKESSPFINSTD CCCCCCCCCCCCCCC	25.56	25521595
54	Phosphorylation	ESSPFINSTDTEKGR CCCCCCCCCCCCCCC	23.89	25521595
55	Phosphorylation	SSPFINSTDTEKGRE CCCCCCCCCCCCCCE	42.31	25521595
57	Phosphorylation	PFINSTDTEKGREYD CCCCCCCCCCCCEEC	39.42	25521595
59	Ubiquitination	INSTDTEKGREYDGR CCCCCCCCCCEECCC	66.42	22790023
111	Ubiquitination	AENNEGGKKKPVQAP HHCCCCCCCCCCCCC	69.36	-
388	Ubiquitination	LWSSYLTKGVIVERR CHHHHCCCCEEEEEC	48.89	22790023
442	N-linked_Glycosylation	TGIMAGSNRSGDLRD CEECCCCCCCCCHHH	41.02	-
672	Phosphorylation	GDGIRGLSLSAARYA CCCHHHHHHHHHHHH	24.09	22817900
674	Phosphorylation	GIRGLSLSAARYALL CHHHHHHHHHHHHHH	19.26	20415495
678	Phosphorylation	LSLSAARYALLRLEE HHHHHHHHHHHHCCC	9.25	29514104
691	Ubiquitination	EEGPPHTKNWRPQLL CCCCCCCCCCCCEEE	52.02	22790023
833	N-linked_Glycosylation	LALLVTKNVSMFPGN HHEEEECCCCCCCCC	23.02	-
878	Acetylation	HKVWRKCKMRIFTVA HHHHHHCCCEEEEEE	33.96	7624253
895	Ubiquitination	DDNSIQMKKDLTTFL CCCCEECHHHHHHHH	27.10	22790023
896	Ubiquitination	DNSIQMKKDLTTFLY CCCEECHHHHHHHHH	53.26	22790023
926	Phosphorylation	SDISAYTYEKTLVME HCCCEEEECCHHHHH	11.62	20600929
929	Phosphorylation	SAYTYEKTLVMEQRS CEEEECCHHHHHHHH	16.79	19665974
936	Phosphorylation	TLVMEQRSQILKQMH HHHHHHHHHHHHHHC	22.67	29899451
940	Phosphorylation	EQRSQILKQMHLTKN HHHHHHHHHHCCCCC	47.40	17693402
940	Ubiquitination	EQRSQILKQMHLTKN HHHHHHHHHHCCCCC	47.40	22790023
955	Phosphorylation	EREREIQSITDESRG HHHHHHHHCCCCCCC	32.87	22324799
957	Phosphorylation	EREIQSITDESRGSI HHHHHHCCCCCCCCC	38.67	24925903
960	Phosphorylation	IQSITDESRGSIRRK HHHCCCCCCCCCCCC	44.76	22324799
963	Phosphorylation	ITDESRGSIRRKNPA CCCCCCCCCCCCCCC	16.29	25521595
1011	Phosphorylation	SCPSSSPSPGEEPEG CCCCCCCCCCCCCCC	47.70	-
1022	Phosphorylation	EPEGERETDPEVHLT CCCCCCCCCCCCEEE	64.18	21183079
1029	Phosphorylation	TDPEVHLTWTKDKSV CCCCCEEEEECCHHH	19.06	19665974
1031	Phosphorylation	PEVHLTWTKDKSVAE CCCEEEEECCHHHHH	24.91	25521595
1041	Ubiquitination	KSVAEKNKGPSPVSS HHHHHHCCCCCCCCC	81.11	22790023
1044	Phosphorylation	AEKNKGPSPVSSEGI HHHCCCCCCCCCCHH	46.75	25521595
1047	Phosphorylation	NKGPSPVSSEGIKDF CCCCCCCCCCHHHHH	26.51	22324799
1048	Phosphorylation	KGPSPVSSEGIKDFF CCCCCCCCCHHHHHH	39.82	25521595
1052	Ubiquitination	PVSSEGIKDFFSMKP CCCCCHHHHHHHCCH	60.38	22790023
1056	Phosphorylation	EGIKDFFSMKPEWEN CHHHHHHHCCHHHHC	26.37	22807455
1058	Ubiquitination	IKDFFSMKPEWENLN HHHHHHCCHHHHCCC	38.29	22790023
1067	Phosphorylation	EWENLNQSNVRRMHT HHHCCCHHHHHHHHH	35.90	-
1085	Ubiquitination	LNEVIVNKSRDAKLV HCEEEEECCCCCCEE	35.65	22790023
1090	Ubiquitination	VNKSRDAKLVLLNMP EECCCCCCEEEECCC	43.34	22790023
1109	Phosphorylation	NRNGDENYMEFLEVL CCCCCCCHHHHHHHH	8.93	20600929

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
940	S	Phosphorylation	Kinase	PKCA	P20444	PSP
940	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
963	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S12A5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S12A5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of S12A5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.