S12A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S12A1_MOUSE
• UniProt AC: P55014
• Protein Name: Solute carrier family 12 member 1
• Gene Name: Slc12a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1095
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume..
• Protein Sequence: MSVSIPSNSVPSSASRFQVHVINEGHGSAAAVGDSADPPHYEETSFGDEAQNRLRISFRPGNQECYDNFLQTGETAKTDTTFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAENKEEDMTGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSGMNCNGSAACGLGYDFSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEKLEQERLALEAAIKDNECEEGKGGIRGLFKKAGKLNITKPAPKKDGNISSIQSMHVGEFNQKLVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKITRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAEKLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	AQNRLRISFRPGNQE HHHCEEEEECCCCHH	14.58	19060867
66	Phosphorylation	RPGNQECYDNFLQTG CCCCHHHHHCHHHCC	17.11	21183079
78	Phosphorylation	QTGETAKTDTTFHAY HCCCCCCCCCEEEEE	35.79	21183079
81	Phosphorylation	ETAKTDTTFHAYDSH CCCCCCCEEEEEECC	19.08	21183079
85	Phosphorylation	TDTTFHAYDSHTNTY CCCEEEEEECCCCEE	14.92	21183079
87	Phosphorylation	TTFHAYDSHTNTYYL CEEEEEECCCCEEEE	21.38	19060867
89	Phosphorylation	FHAYDSHTNTYYLQT EEEEECCCCEEEEEE	32.96	21082442
91	Phosphorylation	AYDSHTNTYYLQTFG EEECCCCEEEEEEEC	18.07	19060867
92	Phosphorylation	YDSHTNTYYLQTFGH EECCCCEEEEEEECC	12.30	21183079
93	Phosphorylation	DSHTNTYYLQTFGHN ECCCCEEEEEEECCC	7.12	21183079
96	Phosphorylation	TNTYYLQTFGHNTMD CCEEEEEEECCCCCC	29.05	19060867
101	Phosphorylation	LQTFGHNTMDAVPKI EEEECCCCCCCCCCE	15.68	19060867
110	Phosphorylation	DAVPKIEYYRNTGSV CCCCCEEEECCCCCC	15.93	25195567
111	Phosphorylation	AVPKIEYYRNTGSVS CCCCEEEECCCCCCC	5.65	19060867
114	Phosphorylation	KIEYYRNTGSVSGPK CEEEECCCCCCCCCC	23.10	19060867
116	Phosphorylation	EYYRNTGSVSGPKVN EEECCCCCCCCCCCC	15.86	19060867
121	Ubiquitination	TGSVSGPKVNRPSLL CCCCCCCCCCCCHHH	56.52	-
126	Phosphorylation	GPKVNRPSLLEIHEQ CCCCCCCHHHHHHHH	42.20	17341212
136	Ubiquitination	EIHEQLAKNVTVAPG HHHHHHHCCCEECCC	61.62	-
144	Phosphorylation	NVTVAPGSADRVANG CCEECCCCCCCCCCC	26.41	19060867
442	N-linked_Glycosylation	RDATGSMNDTIVSGM HCCCCCCCCEEEECC	44.99	-
452	N-linked_Glycosylation	IVSGMNCNGSAACGL EEECCCCCCCCCCCC	42.31	-
520	Ubiquitination	KVFQALCKDNIFKGL HHHHHHCCCCCHHHH	55.44	-
525	Ubiquitination	LCKDNIFKGLQFFAK HCCCCCHHHHHHHHH	55.72	-
722	Ubiquitination	GPRKLCVKEMNSGMA CCHHHHHHHHCCCCC	50.69	-
737	Ubiquitination	KKQAWLIKNKIKAFY HHHHHHHHHHHHHHH	50.44	-
758	Phosphorylation	CFRDGVRSLLQASGL HHHHHHHHHHHHCCC	30.90	28576409
763	Phosphorylation	VRSLLQASGLGRMKP HHHHHHHCCCCCCCC	22.91	28576409
818	Phosphorylation	ISQGFDISPVLQVQD EECCCCCCCEEEHHH	15.70	25195567
829	Ubiquitination	QVQDELEKLEQERLA EHHHHHHHHHHHHHH	70.69	-
842	Ubiquitination	LALEAAIKDNECEEG HHHHHHHHHCCCCCC	50.18	-
850	Ubiquitination	DNECEEGKGGIRGLF HCCCCCCCCCHHHHH	58.19	-
867	Ubiquitination	AGKLNITKPAPKKDG CCCCCCCCCCCCCCC	35.07	-
871	Ubiquitination	NITKPAPKKDGNISS CCCCCCCCCCCCCCC	66.65	-
872	Ubiquitination	ITKPAPKKDGNISSI CCCCCCCCCCCCCCC	70.57	-
877	Phosphorylation	PKKDGNISSIQSMHV CCCCCCCCCCEECCH	25.95	21183079
878	Phosphorylation	KKDGNISSIQSMHVG CCCCCCCCCEECCHH	22.35	21082442
881	Phosphorylation	GNISSIQSMHVGEFN CCCCCCEECCHHHHH	14.80	19060867
890	Ubiquitination	HVGEFNQKLVEASAQ CHHHHHHHHHHHHHH	56.45	-
899	Ubiquitination	VEASAQFKKKQGKGT HHHHHHHHHHCCCCE	47.16	-
957	Phosphorylation	EEKISMASLLSKFRI HHHCCHHHHHHCCCC	22.62	25195567
961	Acetylation	SMASLLSKFRIKFAD CHHHHHHCCCCEECE	38.33	23576753
961	Ubiquitination	SMASLLSKFRIKFAD CHHHHHHCCCCEECE	38.33	-
978	Ubiquitination	IIGDINIKPNKESWK EEEEEECCCCHHHHH	37.74	-
1001	Ubiquitination	YRLHESHKDLTTAEK HHCCHHCCCCHHHHH	64.81	-
1008	Ubiquitination	KDLTTAEKLKRESPW CCCHHHHHHHHHCCC	57.77	-
1026	Ubiquitination	DAELEAVKEKSYRQV HHHHHHHHHHHHHHH	67.48	-
1052	Phosphorylation	AANLIVLSLPVARKG HHCEEEEECCCCCCC	21.52	-
1088	Ubiquitination	LLVRGNHKNVLTFYS EEEECCCCCEEEEEC	53.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
126	S	Phosphorylation	Kinase	PRKAA1	Q5EG47	GPS
126	S	Phosphorylation	Kinase	AMPK	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S12A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S12A1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OS9_HUMAN	OS9	physical	26721884

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.