S10A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S10A1_MOUSE
• UniProt AC: P56565
• Protein Name: Protein S100-A1
• Gene Name: S100a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 94
• Subcellular Localization: Cytoplasm .
• Protein Description: Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity..
• Protein Sequence: MGSELESAMETLINVFHAHSGQEGDKYKLSKKELKDLLQTELSGFLDVQKDADAVDKVMKELDENGDGEVDFKEYVVLVAALTVACNNFFWETS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	SGFLDVQKDADAVDK HCCCCHHCCHHHHHH	55.52	-
57	Ubiquitination	KDADAVDKVMKELDE CCHHHHHHHHHHHHH	37.32	-
86	S-nitrosocysteine	VAALTVACNNFFWET HHHHHHHHHHHHHCC	3.58	-
86	S-nitrosylation	VAALTVACNNFFWET HHHHHHHHHHHHHCC	3.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S10A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S10A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S10A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of S10A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.