RXT3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RXT3_SCHPO
• UniProt AC: O94707
• Protein Name: Transcriptional regulatory protein rxt3
• Gene Name: rxt3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 351
• Subcellular Localization: Nucleus.
• Protein Description: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity)..
• Protein Sequence: MEEKTPENEQSKKTFDPKDSMKIEETSTNGSSQPSQPSNIKLSIGSILESSNDNGDPEYSENGMGNMNMNTLPMATSTPMSYTKQPSEAKYPNSVWERKGVSDQEENTSSVKRQKTLPTQSSGEEEAKYSHPGAPTATSADSISMESRPSNLSTSLSKTTSYPQFQVRQFVSPIISIDNSALEPFLNRYPASESLFPVTEYEYTPWLEFPLLYSSIGKFVRVTIDIKWLNAAINPRLCRREIWGTDVYTDDSDIATILAHCGCFSLLKPVRKIAVVDLYILPPLVHYKGTRKNQIESRSWSSRQDGISLKIKEVTWKPACASIFENSIHTLTLEERLQARLELSRSSTFKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEKTPENEQSK ---CCCCCCCCHHHC		29996109
11	Phosphorylation	KTPENEQSKKTFDPK CCCCCHHHCCCCCHH		29996109
28	Phosphorylation	MKIEETSTNGSSQPS CCEEEECCCCCCCCC		27738172
31	Phosphorylation	EETSTNGSSQPSQPS EEECCCCCCCCCCCC		27738172
102	Phosphorylation	VWERKGVSDQEENTS HHHCCCCCCCCCCCH		21712547
108	Phosphorylation	VSDQEENTSSVKRQK CCCCCCCCHHHCCCC		29996109
109	Phosphorylation	SDQEENTSSVKRQKT CCCCCCCHHHCCCCC		29996109
110	Phosphorylation	DQEENTSSVKRQKTL CCCCCCHHHCCCCCC		29996109
116	Phosphorylation	SSVKRQKTLPTQSSG HHHCCCCCCCCCCCC		27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RXT3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RXT3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RXT3_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of RXT3_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.