| UniProt ID | RXRB_MOUSE | |
|---|---|---|
| UniProt AC | P28704 | |
| Protein Name | Retinoic acid receptor RXR-beta | |
| Gene Name | Rxrb | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 520 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).. | |
| Protein Sequence | MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAGEQQALEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIRPSSPPGPPLTPSAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGATGGGGSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Methylation | QCGPVGVRKEMHCGV CCCCCCCCCCCCCCC | 24.24 | - | |
| 35 | Dimethylation | MHCGVASRWRRRRPW CCCCCCCCHHHHCCC | 22.60 | - | |
| 35 | Methylation | MHCGVASRWRRRRPW CCCCCCCCHHHHCCC | 22.60 | 58856377 | |
| 79 | Phosphorylation | DSGRDSRSPDSSSPN CCCCCCCCCCCCCCC | 36.69 | 22817900 | |
| 82 | Phosphorylation | RDSRSPDSSSPNPLS CCCCCCCCCCCCCCC | 35.78 | 20415495 | |
| 83 | Phosphorylation | DSRSPDSSSPNPLSQ CCCCCCCCCCCCCCC | 58.14 | 28066266 | |
| 84 | Phosphorylation | SRSPDSSSPNPLSQG CCCCCCCCCCCCCCC | 32.42 | 28066266 | |
| 89 | Phosphorylation | SSSPNPLSQGIRPSS CCCCCCCCCCCCCCC | 27.84 | 28066266 | |
| 302 | Phosphorylation | ELAVEQKSDQGVEGP HHHHHHCCCCCCCCC | 34.56 | 26643407 | |
| 312 | Phosphorylation | GVEGPGATGGGGSSP CCCCCCCCCCCCCCC | 42.13 | 26745281 | |
| 317 | Phosphorylation | GATGGGGSSPNDPVT CCCCCCCCCCCCHHH | 45.99 | 26745281 | |
| 318 | Phosphorylation | ATGGGGSSPNDPVTN CCCCCCCCCCCHHHH | 30.88 | 26745281 | |
| 324 | Phosphorylation | SSPNDPVTNICQAAD CCCCCHHHHHHHHHH | 25.01 | 23984901 | |
| 439 | Ubiquitination | ILFNPDAKGLSNPGE HHCCCCCCCCCCCCC | 68.70 | - | |
| 475 | Ubiquitination | EQQGRFAKLLLRLPA HHCCHHHHHHHHHHH | 36.63 | - | |
| 485 | O-linked_Glycosylation | LRLPALRSIGLKCLE HHHHHHHHHHHHHHH | 23.12 | 30059200 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RXRB_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RXRB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RXRB_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RXRB_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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