RUFY3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUFY3_RAT
• UniProt AC: Q5FVJ0
• Protein Name: Protein RUFY3 {ECO:0000305}
• Gene Name: Rufy3 {ECO:0000312|RGD:1565242}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 469
• Subcellular Localization: Cytoplasm . Endomembrane system . Cell projection, invadopodium . Perikaryon . Cell projection . Cell projection, growth cone . Cell projection, filopodium . Cell projection, lamellipodium . Localized in F-actin-enriched filopodia and lamellipodia at
• Protein Description: Plays a role in the generation of neuronal polarity formation and axon growth. [PubMed: 17439943 Implicated in the formation of a single axon by developing neurons]
• Protein Sequence: MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEANALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYLLESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSALTPPTD ------CCCCCCCCC	31.80	22673903
5	Phosphorylation	---MSALTPPTDMPT ---CCCCCCCCCCCC	27.26	30240740
8	Phosphorylation	MSALTPPTDMPTPTT CCCCCCCCCCCCCCC	46.24	22673903
12	Phosphorylation	TPPTDMPTPTTDKIT CCCCCCCCCCCCHHH	26.99	22673903
14	Phosphorylation	PTDMPTPTTDKITQA CCCCCCCCCCHHHHH	50.54	22673903
34	Phosphorylation	YLCKFRVSMDGEWLC HHCEEEECCCCCEEE	13.60	-
49	Phosphorylation	LRELDDISLTPDPEP EEECCCCCCCCCCCC	32.93	30240740
51	Phosphorylation	ELDDISLTPDPEPTH ECCCCCCCCCCCCCC	20.89	17439943
57	Phosphorylation	LTPDPEPTHEDPNYL CCCCCCCCCCCCCCH	35.91	28551015
157	Ubiquitination	VKDLPGLKTPVGRGR CCCCCCCCCCCCHHH	57.61	-
247	Phosphorylation	MYLKDGNSSKGSEGD EEEECCCCCCCCCCC	38.67	25575281
248	Phosphorylation	YLKDGNSSKGSEGDG EEECCCCCCCCCCCC	45.06	25575281
249	Ubiquitination	LKDGNSSKGSEGDGQ EECCCCCCCCCCCCC	67.30	-
251	Phosphorylation	DGNSSKGSEGDGQIT CCCCCCCCCCCCCEE	41.99	25575281
294	Ubiquitination	ALEKSNTKLTEELAV HHHHCCCHHHHHHHH	58.63	-
350	Ubiquitination	SEARKHLKEETQLRL HHHHHHHHHHHHHHC	53.90	-
382	Ubiquitination	LAMKMLEKDVCEKQD HHHHHHHHHHHHHHH	52.04	-
387	Ubiquitination	LEKDVCEKQDALVSL HHHHHHHHHHHHHHH	48.64	-
405	Acetylation	LDDLRALKHELAFKL HHHHHHHHHHHHHHH	33.76	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUFY3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUFY3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUFY3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RUFY3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.