RTL1_HUMAN - dbPTM
RTL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RTL1_HUMAN
UniProt AC A6NKG5
Protein Name Retrotransposon-like protein 1
Gene Name RTL1
Organism Homo sapiens (Human).
Sequence Length 1358
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta..
Protein Sequence MIEPSEDSFETMMEHKNPSSKQMESSEGSSNTTEATSGSGVRGEAGPASGPAQEKKEPPSGPLQEMEELPTDLLQDMEEPSSGPRKEIEDPPNDLLQDLEESCNGSHQARGDPLSGASDRMKEASVNPSGAREEQEAHTDLKESGREETPQEQNQTEHSTAELMAMVRSIISLYFRMQDLKEQQRVAEEILIKGINAGQLPAPKHFSGDRREFHEFIVLCQLTLQSYPRMFYNDRLRVGYVINHLSGLALEWAKALLQENSPLIGDFPAFLEAMSEVFEYRQALRVAEEAMFTIRQGGRSATEYIDEFQSLVPILGWPDEVLQAHLCQGLNEEIRHYLFRVPQPDSLDSLIVLILQIEEKLAERRAMLRLPPEARPRNLTWIDSPAPERWMVSSWLPSEVHPDINRAHLFLLLMVRVNPYHSVAVQALVDSGADGNFMDEKFAQEHYVELYEKPYPQPVQSVDGSLIGNEPVWLYTEPLVCIHQNHQESIEFDIVPSPNFSVVLGIRWLRVHAPEVDWIKGRCTFHSPYCLKNCFRPPPPCIALERHGMSLLPGLPHPYSDLADVFNPKEADDETSDQPSSDGSDDLSESEPSELQQAGDSDHSETFYECPSTAPWEPVGARMQERARLQEEYWDLQDMLTNRQDYIQMIPELFDQLHGAEWFTKLELRGTIVEESVNGHRTEDVWKAAFGLELEEMKSYQPFALSPDPIIPQNVIHFILKDMLGFFVLSYGQEVLIYSMSQEEHLHHVRQVLVRFRHHNVYCSLDKSQFHRQTVEFLGFVVTPKGVKLNKNVMTIITGYPTPGSKLSLRNFIEFVFPYRHFVERFSIIAEPLVRQLLSSYQFYWGVEEQEAFECLKRAFRKAPLLHHPKPQNPFYLETGVTGTALHASLIQIDDQTGKRACCAFYSRNISPIEVEYSQAEMKILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFDVMELPEQDGGRALPPVRNLRWRRAFQRNTAARQTLLLASRGFPRDPSTESGEEENEEQDELNEQILRQELLAMIPIDQILNSFLAHFSMAQIRAVILHFFRGLLYWKNTLALAAILVLLRVRQCLSLRPAPAMRVARPQPQRSLRLILDSSLIAGSSITTAITQLLTQMPALVGANTIPAQELAELFLGPGRWQRNALHSQAHRGLQFTPGFWLTLCEFFGVRVTPQEGHLPALRQNRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDKQDNDVQEAPPSHTAATHPPRPRHLMDPQVLEFLGSRLLHIHSADGQLHLLSREQAARALSQFLTLIYRRALPIPAWESQPREQARLEELPDEDEDANLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationMMEHKNPSSKQMESS
HHHCCCCCHHHCCCC		60.61-
21UbiquitinationEHKNPSSKQMESSEG
HCCCCCHHHCCCCCC		58.98-
55UbiquitinationASGPAQEKKEPPSGP
CCCCCCCCCCCCCCC		50.81-
122UbiquitinationSGASDRMKEASVNPS
CCCHHHHHHCCCCCC		51.53-
142UbiquitinationQEAHTDLKESGREET
HHHHHHHHHHCCCCC		53.28-
181UbiquitinationYFRMQDLKEQQRVAE
HHHHCCHHHHHHHHH		3.56-
193UbiquitinationVAEEILIKGINAGQL
HHHHHHHHCCCCCCC		4.76-
204UbiquitinationAGQLPAPKHFSGDRR
CCCCCCCCCCCCCCH		28.81-
293PhosphorylationVAEEAMFTIRQGGRS
HHHHHHHHHHCCCCC		7.0924719451
380PhosphorylationEARPRNLTWIDSPAP
CCCCCCCCCCCCCCC		4.4228842319
384PhosphorylationRNLTWIDSPAPERWM
CCCCCCCCCCCCCCC		39.8828842319
520SumoylationAPEVDWIKGRCTFHS
CCCCCEECCCEEECC		2.68-
520UbiquitinationAPEVDWIKGRCTFHS
CCCCCEECCCEEECC		2.68-
520SumoylationAPEVDWIKGRCTFHS
CCCCCEECCCEEECC		2.68-
687UbiquitinationHRTEDVWKAAFGLEL
CCCHHHHHHHHCCCH		9.26-
785UbiquitinationLGFVVTPKGVKLNKN
EEEEECCCCCCCCCC		21.57-
791UbiquitinationPKGVKLNKNVMTIIT
CCCCCCCCCEEEEEE		28.30-
795PhosphorylationKLNKNVMTIITGYPT
CCCCCEEEEEECCCC		2.8929759185
800PhosphorylationVMTIITGYPTPGSKL
EEEEEECCCCCCCHH		18.9326546556
802PhosphorylationTIITGYPTPGSKLSL
EEEECCCCCCCHHHH		33.2029759185
805PhosphorylationTGYPTPGSKLSLRNF
ECCCCCCCHHHHHHH		39.6329759185
806UbiquitinationGYPTPGSKLSLRNFI
CCCCCCCHHHHHHHH		31.46-
808PhosphorylationPTPGSKLSLRNFIEF
CCCCCHHHHHHHHHH		6.6324719451
839PhosphorylationPLVRQLLSSYQFYWG
HHHHHHHHHCCCCCC		2.12-
899UbiquitinationQIDDQTGKRACCAFY
EEECCCCCEEEEHHH		16.30-
911PhosphorylationAFYSRNISPIEVEYS
HHHCCCCCCEEEEEC		5.14-
923UbiquitinationEYSQAEMKILPIRAA
EECHHHHCCHHHHHH		3.52-
1027PhosphorylationRGFPRDPSTESGEEE
CCCCCCCCCCCCCCC		44.4225921289
1028PhosphorylationGFPRDPSTESGEEEN
CCCCCCCCCCCCCCC		49.4425921289
1030PhosphorylationPRDPSTESGEEENEE
CCCCCCCCCCCCCHH		62.1725921289
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RTL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RTL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RTL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RTL1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RTL1_HUMAN

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Related Literatures of Post-Translational Modification

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