RSSA_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSSA_RAT
• UniProt AC: P38983
• Protein Name: 40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03016}
• Gene Name: Rpsa
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 295
• Subcellular Localization: Cell membrane . Cytoplasm . Nucleus . 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Coloca
• Protein Description: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA..
• Protein Sequence: MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGGLDVLQ ------CCCCCCEEE	41.38	15548204
43	Phosphorylation	QYIYKRKSDGIYIIN HHEEEECCCCEEEEE	45.14	23984901
52	Acetylation	GIYIINLKRTWEKLL CEEEEECCCHHHHHH	43.21	22902405
75	Phosphorylation	IENPADVSVISSRNT ECCCCCEEEEECCCC	17.80	23984901
78	Phosphorylation	PADVSVISSRNTGQR CCCEEEEECCCCCHH	22.53	23984901
79	Phosphorylation	ADVSVISSRNTGQRA CCEEEEECCCCCHHH	20.58	23984901
82	Phosphorylation	SVISSRNTGQRAVLK EEEECCCCCHHHHHH	33.31	23984901
89	Acetylation	TGQRAVLKFAAATGA CCHHHHHHHHHHCCC	26.76	-
89	Ubiquitination	TGQRAVLKFAAATGA CCHHHHHHHHHHCCC	26.76	-
94	Phosphorylation	VLKFAAATGATPIAG HHHHHHHCCCCCCCC	23.71	23984901
97	Phosphorylation	FAAATGATPIAGRFT HHHHCCCCCCCCCCC	19.30	23984901
135	Phosphorylation	RADHQPLTEASYVNL CCCCCCCCCCCCCCC	35.87	23984901
138	Phosphorylation	HQPLTEASYVNLPTI CCCCCCCCCCCCCEE	24.31	23984901
139	Phosphorylation	QPLTEASYVNLPTIA CCCCCCCCCCCCEEE	10.62	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSSA_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSSA_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSSA_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RSSA_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Cellular prion protein/laminin receptor: distribution in adultcentral nervous system and characterization of an isoform associatedwith a subtype of cortical neurons.";
Baloui H., von Boxberg Y., Vinh J., Weiss S., Rossier J., Nothias F.,Stettler O.;
Eur. J. Neurosci. 20:2605-2616(2004).
Cited for: PROTEIN SEQUENCE OF 2-11; 43-52; 90-102 AND 156-166, CLEAVAGE OFINITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY,SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed: 15548204