RSCA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSCA1_MOUSE
• UniProt AC: Q9ER99
• Protein Name: Regulatory solute carrier protein family 1 member 1
• Gene Name: Rsc1a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 582
• Subcellular Localization: Cell membrane . Nucleus . Golgi apparatus, trans-Golgi network. Localizes at the inner side of the plasma membrane.
• Protein Description: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine..
• Protein Sequence: MSSLPTSDGFDHPAPSGQSPEVGSPTSLARSVSASVCAIKPGDPNSIESLAMEATKASAEFQTNSKKTDPPPLQVLPDLASSAEQSLAMPFHKSSKEAVVAGNLEKSVEKGTQGLRVYLHTRQDASLTLTTTGMREPQIFAEEKSWHPENQTPSPVNGLQQHRETGSVQREAGQQSVPQDQGCLCDAEDLELHEEVVSLEALRKGELQRHAHLPSAEKGLPASGLCSCPCSEALMEVDTAEQSLVAMCSSTGRQDAVIKSPSVAHLASDNPTMEVETLQSNPSCEPVEHSILTRELQLPEDNVDMSTMDNKDDNSSSLLSGHGQPSVESAEEFCSSVTVALKELHELLVISCKPASEESPEHVTCQSEIGAESQPSVSDLSGRRVQSVHLTPSDQYSQGSCHQATSESGKTEIVGTAPCAAVEDEASTSFEGLGDGLSPDREDVRRSTESARKSCSVAITSAKLSEQLPCTSGVEIAPELAASEGAHSQPSEHVHNPGPDRPETSSVCPGAGLPRSGLDQPPTQSLSTPSVLPPFIFPAADVDRILGAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	TSLARSVSASVCAIK HHHHHHHCEEEEEEC	18.97	21082442
35	Phosphorylation	LARSVSASVCAIKPG HHHHHCEEEEEECCC	15.38	28059163
121	Phosphorylation	GLRVYLHTRQDASLT CEEEEEEECCCCEEE	27.68	24704852
438	Phosphorylation	EGLGDGLSPDREDVR CCCCCCCCCCHHHHH	30.22	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSCA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSCA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSCA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RSCA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.